Ultraviolet B radiation suppresses Langerhans cell migration in the dermis by down-regulation of α4 integrin

Photodermatology Photoimmunology and Photomedicine

Volumn 22, Issue 3, 2006, Pages 116-123

  Hamakawa, Motoko ^a   Sugihara, Akira ^a   Okamoto, Hiroyuki ^a   Horio, Takeshi ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Cord formation; Fibronectin; Integrin 4; Langerhans cell; Migration

Indexed keywords

ALPHA4 INTEGRIN; ALPHA6 INTEGRIN; BETA1 INTEGRIN; BETA4 INTEGRIN; FIBRONECTIN; LAMININ; SECONDARY LYMPHOID TISSUE CHEMOKINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL COUNT; CELL CULTURE; CELL ISOLATION; CELL MIGRATION; CELL SUSPENSION; CONTROLLED STUDY; DOWN REGULATION; EXPLANT; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; LANGERHANS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CULTURE; ULTRAVIOLET B RADIATION;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; DERMATITIS, CONTACT; DERMIS; DOWN-REGULATION; IMMUNE TOLERANCE; INTEGRIN ALPHA4; LANGERHANS CELLS; MICE; MICE, INBRED BALB C; ULTRAVIOLET RAYS;

EID: 33744458252     PISSN: 09054383     EISSN: 16000781     Source Type: Journal    
DOI: 10.1111/j.1600-0781.2006.00187.x     Document Type: Article

References (35)

1. Rowden G, Lewis MG, Sullivan AK. Ia antigen expression on human epidermal Langerhans cells. Nature 1977; 268: 247-248.
2. Shelly WB, Juhlin L. Langerhans cells from reticulo epithelial trap for external contact antigens. Nature 1976; 261: 46-47.
3. Toews GB, Bergstresser PR, Streilein JW, Sullivan S. Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 1980; 124: 445-453.
4. Romani N, Schler G, Fritsch P. Identification and phenotype of epidermal Langerhans cells. In: Schuler G., ed. Epidermal Langerhans cells. Boca Raton: CRC Press, 1991; 49-72.
5. Teunissen MJM, Kapsenberg ML, Bos JD. Langerhans cells and related skin dendritic cells. In: Bos JD., ed. Skin Immune System, 2nd edn. Boca Raton: CRC Press, 1991; 159-180.
6. Aberer W, Schuler G, Stingl G, Honigsmann H, Wolff K. Ultraviolet light depletes surface markers on Langerhans cells. J Invest Dermatol 1981; 76: 202-210.
7. Humm SA, Cole S. Changes with time in Langerhans cell number, ATPase reactivity and morphology in murine epidermis after exposure to UVB. Photodermatol 1986; 3: 174-178.
8. Moodycliff AM, Kimber I, Norval M. Role of tumor necrosis factor-alpha in ultraviolet B light-induced dendritic cell migration and suppression of contact hypersensitivity. Immunology 1994; 81: 79-84.
9. Kremer IB, Sylva-Steenland RM, Bos JD, Teunissen MB. Despite the presence of UVB-induced DNA damage, HLA-DR+cells from ex vivo UVB-exposed human skin are able to migrate and show no impaired allostimulatory capacity. J Invest Dermatol 1997; 109: 626-631.
10. Rattis FM, Concha M, Dalbiez-Gauthier C, Courtellemont P, Schmitt D, Peguet-Navarro J. Effects of ultraviolet B radiation on human Langerhans cells: Functional alteration of CD86 upregulation and induction of apoptotic cell death. J Invest Dermatol 1998; 111: 373-379.
11. Kölgen W, Both H, van Weelden H, et al. Epidermal Langerhans cell depletion after artificial ultraviolet B irradiation of human skin in vivo: Apoptosis versus migration. J Invest Dermatol 2002; 118: 812-817.
12. Okamoto H, Mizuno K, Itoh T, Tanaka K, Horio T. Evaluation of apoptotic cells induced by ultraviolet light B radiation in epidermal sheets stained by the TUNEL technique. J Invest Dermatol 1999; 113: 802-807.
13. Sontag Y, Guikers CL, Vink AA, et al. Cells with UV-specific DNA damage are present in murine lymp nodes after in vivo UV irradiation. J Invest Dermatol 1995; 104: 734-738.
14. Richters CD, Reits EA, Van Pelt AM, et al. Effect of low dose UVB radiation on the migratory properties and functional capacities of human skin dendritic cells. Clin Exp Immunol 1996; 104: 191-197.
15. Tang JM, Dunner K Jr, Kripke ML, Bucana C. Characteristics of antigen-presenting cells involved in contact sensitization of normal and UV-irradiated mice. J Invest Dermatol 1992; 99: 20S-22S.
16. Cumberbatch M, Dearman RJ, Kimber I. Langerhans cell require signals from both tumor necrosis factor-alpha and interleukin-1 beta for migration. Immunology 1997; 92: 388-395.
17. Stoitzner P, Zanella M, Ortner U, et al. Migration of Langerhans cells and dermal dendritic cells in skin organ cultures: Augmentation by TNF-alpha and IL-1 beta. J Leukoc Biol 1999; 66: 462-470.
18. Schwarzenberger K, Udey MC. Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell E-cadherin expression in situ. J Invest Dermatol 1996; 106: 553-558.
19. Martin GR, Rohrbach DH, Terranova VP, Liotta LA. Structure, function, and pathology of basement membranes. Monogr Pathol 1983; 24: 16-30.
20. Hynes RO, Yamada KM. Fibronectins: Multifunctional modular glycoproteins. J Cell Biol 1982; 95 (2 Pt 1): 369-377.
21. Le Varlet B, Dezutter-Dambuyant C, Staquet MJ, Delorme P, Schmitt D. Human epidermal Langerhans cells express integrins of the beta 1 subfamily. J Invest Dermatol 1991; 96: 518-522.
22. Staquet MJ, Le Varlet B, Dezutter-Dambuyant C, Schmitt D. Human epidermal Langerhans cells express beta 1 integrins that mediate their adhesion to laminin and fibronectin. J Invest Dermatol 1992; 99: 12S-14S.
23. Price AA, Cumberbatch M, Kimber I, Ager A. Alpha 6 integrins are required for Langerhans cell migration from the epidermis. J Exp Med 1997; 186: 1725-1735.
24. Aiba S, Nakagawa S, Ozawa H, Miyake K, Yagita H, Tagami H. Up-regulation of alpha 4 Integrin on activated Langerhans cells: Analysis of adhesion molecules on Langerhans cells relating to their migration from skin to draining lymph nodes. J Invest Dermatol 1993; 100: 143-147.
25. Kellermann SA, Hudak S, Oldham ER, Liu YJ, McEvoy LM. The CC Chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3 beta are potent chemoattractants for in vito- and in vivo-derived dendritic cells. J Immunol 1999; 162: 3859-3864.
26. Saeki H, Moore AM, Brown MJ, Hwang ST. Secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7(CCR7) participate in the emigration pathway of murine dendritic cells from skin to regional lymph nodes. J Immunol 1999; 162: 2472-2475.
27. Stoitzner P, Ratzinger G, Koch F, et al. Interleukin-16 supports the migration of Langerhans cells, partly in a CD-4-independent way. J Invest Dermatol 2001; 116: 641-649.
28. Aiba S, Masuko T, Hosokawa M, Hashimoto Y. Monoclonal antibodies to various morphologic components of human skin. J Invest Dermatol 1983; 81: 498-502.
29. Koyama Y, Kobayashi M, Ohashi K, et al. Isolation and culture of panning method-enriched Langerhans cells from dispase-dissociated epidermal cells of the mouse. J Dermatol 1990; 17: 211-217.
30. Staquet MJ, Kobayashi Y, Dezutter-Dambuyant C, Schmitt D. Role of specific successive contacts between extracellular matrix proteins and epidermal Langerhans cells in the control of their directed migration. Eur J Cell Biol 1995; 66: 342-348.
31. Larsen CP, Steinman RM, Witmer-Pack M, Hankins DF, Morris PJ, Austyn JM. Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med 1990; 172: 1483-1493.
32. Yamazaki S, Yokozeki H, Satoh T, Katayama I, Nishioka K. TNF-alpha, RANTES, and MCP-1 are major chemoattractants of murine Langerhans cells to the regional lymph node. Exp Dermatol 1998; 7: 35-41.
33. Schweickart VL, Raport CJ, Godiska R, Byers MG, Eddy RL Jr, Shows TB, Gray PW. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor and encoded on human chromosome 17q12-q21.2. Genomics 1994; 23: 643-50.
34. Aiba S, Katz Sl. Phenotypic and functional characteristics of in vivo-activated Langerhans cells. J Immunol 1990; 145: 2791-2796.
35. Dieu MC, Vanbervliet B, Vicari A, et al. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 1998; 188: 373-386.