Mib-1 proliferation index is an independent predictor of lymph node metastasis in invasive breast cancer: A prospective study on 675 patients

Oncology Reports

Volumn 15, Issue 2, 2006, Pages 425-429

  Marrelli, Daniele ^a   Pinto, Enrico ^a   Neri, Alessandro ^a   Megha, Tiziana ^a   Gioffrè, Walter ^a   Cioppa, Tommaso ^a   De Marco, Giovanni ^a   De Stefano, Alfonso ^a   Roviello, Franco ^a  

^a UNIVERSITY OF SIENA   (Italy)

Author keywords

Breast cancer; Lymph node metastasis; Lymphadenectomy; MIB 1; Multivariate analysis; Proliferation index

Indexed keywords

ESTROGEN RECEPTOR; KI 67 ANTIGEN; PROGESTERONE RECEPTOR; TUMOR MARKER;

ARTICLE; BREAST TUMOR; CANCER STAGING; CELL PROLIFERATION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; PROSPECTIVE STUDY; RISK FACTOR;

BREAST NEOPLASMS; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROSPECTIVE STUDIES; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 33744457340     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.15.2.425     Document Type: Article

References (28)

1. Ravdin PM, de Laurentiis M, Vendely T and Clark GM: Prediction of axillary lymph node status in breast cancer patients by use of prognostic indicators. J Natl Cancer Inst 86: 1771-1775, 1994. (Pubitemid 24373452)
2. Brown DC and Gatter KC: Monoclonal antibody Ki-67: its use in histopathology. Histopathology 17: 489-503, 1990.
3. Gerdes J, Becker MH, Key G and Cattoretti G: Immunohistological detection of tumor growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues. J Pathol 168: 85-86, 1992.
4. Remmele W, Muhlfait V and Keul HG: Estimation of the proliferative activity of human breast cancer tissue by means of the Ki-67 and MIB-1 antibodies - comparative studies on frozen and paraffin sections. Virchows Arch 426: 435-439, 1995.
5. Orucevic A, Reddy VB, Bloom KJ, Bitterman P, Magi-Galluzzi C, Oleske DM, Phillips M, Gould VE, Cobleigh M, Wick MR and Gattuso P: Predictors of lymph node metastasis in T1 breast carcinoma, stratified by patient age. Breast J 8: 349-355, 2002. (Pubitemid 35334649)
6. Bader AA, Tio J, Petru E, Buhner M, Pfahlberg A, Volkholz H and Tulusan AH: T1 breast cancer: identification of patients at low risk of axillary lymph node metastases. Breast Cancer Res Treat 76: 11-17, 2002. (Pubitemid 35178624)
7. Isola JJ, Helin HJ, Helle MJ and Kallioniemi OP: Evaluation of cell proliferation in breast carcinoma. Comparison of Ki-67 immunohistochemical study, DNA flow cytometric analysis, and mitotic count. Cancer 65: 1180-1184, 1990. (Pubitemid 20072055)
8. Keshgegian AA and Cnaan A: Proliferation markers in breast carcinoma. Mitotic figure count, S-phase fraction, proliferating cell nuclear antigen, Ki-67 and MIB-1. Am J Clin Pathol 104: 42-49, 1995.
9. Seshadri R, Leong AS, McCaul K, Firgaira FA, Setlur V and Horsfall DJ: Relationship between p53 gene abnormalities and other tumor characteristics in breast-cancer prognosis. Int J Cancer 69: 135-141, 1996. (Pubitemid 26164863)
10. Spyratos F, Ferrero-Pous M, Trassard M, Hacene K, Phillips E, Tubiana-Hulin M and Le Doussal V: Correlation between MIB-1 and other proliferation markers: clinical implications of the MIB-1 cutoff value. Cancer 94: 2151-2159, 2002. (Pubitemid 34411971)
11. Pinto AE, Andre S, Pereira T, Nobrega S and Soares J: Prognostic comparative study of S-phase fraction and Ki-67 index in breast carcinoma. J Clin Pathol 54: 543-549, 2001. (Pubitemid 32642944)
12. Mirza AN, Mirza NQ, Vlastos G and Singletary SE: Prognostic factors in node-negative breast cancer: a review of studies with sample size more than 200 and follow-up more than 5 years. Ann Surg 235: 10-26, 2002. (Pubitemid 34062395)
13. Offersen BV, Sorensen FB, Knoop A, Overgaard J and the Danish Breast Cancer Cooperative Tumor Biology Committee: The prognostic relevance of estimates of proliferative activity in early breast cancer. Histopathology 43: 573-582, 2003. (Pubitemid 38002346)
14. Elston CW and Ellis IO: Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19: 403-410, 1991.
15. Sobin LH and Wittekind C: TNM classification of malignant tumors. 6th edition. John Wiley & Sons, New York, 2002.
16. Andea AA, Bouwman D, Wallis T and Visscher DW: Correlation of tumor volume and surface area with lymph node status in patients with multifocal/multicentric breast carcinoma. Cancer 100: 20-27, 2004. (Pubitemid 37553535)
17. Marrelli D, De Stefano A, de Manzoni G, Morgagni P, di Leo A and Roviello F: Prediction of recurrence after radical surgery for gastric cancer: a scoring system obtained from a prospective multicenter study. Ann Surg 241: 247-255, 2005.
18. Silverstein MJ, Gierson ED, Waisman JR, Colburn WJ and Gamagami P: Predicting axillary node positivity in patients with invasive carcinoma of the breast by using a combination of T category and palpability. J Am Coll Surg 180: 700-704, 1995.
19. Guarnieri A, Neri A, Correale PP, Lottini M, Testa M, Mariani F, Tucci E, Megha T, Cintorino M and Carli A: Prediction of lymph node status by analysis of prognostic factors and possible indications for elective axillary dissection in T1 breast cancers. Eur J Surg 167: 255-259, 2001. (Pubitemid 32336883)
20. Mengel M, von Wasielewski R, Wiese B, Rudiger T, Muller-Hermelink HK and Kreipe H: Inter-laboratory and inter-observer reproducibility of immunohistochemical assessment of the Ki-67 labelling index in a large multi-centre trial. J Pathol 198: 292-299, 2002. (Pubitemid 35277379)
21. Trihia H, Murray S, Price K, Gelber RD, Golouh R, Goldhirsch A, Coates AS, Collins J, Castiglione-Gertsch M and Gusterson BA; International Breast Cancer Study Group: Ki-67 expression in breast carcinoma: its association with grading systems, clinical parameters, and other prognostic factors - a surrogate marker? Cancer 97: 1321-1331, 2003. (Pubitemid 36237320)
22. Gajdos C, Tartter PI and Bleiweiss IJ: Lymphatic invasion, tumor size, and age are independent predictors of axillary lymph node metastases in women with T1 breast cancers. Ann Surg 230: 692-696, 1999. (Pubitemid 30191832)
23. Schoppmann SF, Bayer G, Aumayr K, et al: Austrian Breast and Colorectal Cancer Study Group. Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer. Ann Surg 240: 306-312, 2004. (Pubitemid 38963023)
24. Viale G, Maiorano E, Pruneri G, Mastropasqua MG, Valentini S, Galimberti V, Zurrida S, Maisonneuve P, Paganelli G and Mazzarol G: Predicting the risk for additional axillary metastases in patients with breast carcinoma and positive sentinel lymph node biopsy. Ann Surg 241: 319-325, 2005.
25. Buxant F, Anaf V, Simon P, Fayt I and Noel JC: Ki-67 immunostaining activity is higher in positive axillary lymph nodes than in the primary breast tumor. Breast Cancer Res Treat 75: 1-3, 2002.
26. Fish EB, Chapman JA and Link MA: Assessment of tumor size for multifocal primary breast cancer. Ann Surg Oncol 5: 442-446, 1998. (Pubitemid 28367070)
27. Goldhirsch A, Glick JH, Gelber RD, Coates AS and Senn HJ: Meeting highlights: International Consensus Panel on the Treatment of Primary Breast Cancer. Seventh International Conference on Adjuvant Therapy of Primary Breast Cancer. J Clin Oncol 19: 3817-3827, 2001. (Pubitemid 32880060)
28. Billgren AM, Tani E, Liedberg A, Skoog L and Rutqvist LE: Prognostic significance of tumor cell proliferation analyzed in fine needle aspirates from primary breast cancer. Breast Cancer Res Treat 71: 161-170, 2002. (Pubitemid 34145373)