Is NAA reduction in normal contralateral cerebral tissue in stroke patients dependent on underlying risk factors?

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 77, Issue 5, 2006, Pages 596-600

  Walker, Paul M ^a,b   Ben Salem, D ^b   Giroud, M ^b   Brunotte, F ^b  

^a Medical University of Dijon   (France)

^b DIJON UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CREATININE; LACTIC ACID; N ACETYLASPARTIC ACID; ASPARTIC ACID; CREATINE; DRUG DERIVATIVE; N-ACETYLASPARTATE;

ADULT; AGED; ARTICLE; BASAL GANGLION; BRAIN TISSUE; CAROTID ARTERY OBSTRUCTION; CEREBRAL ARTERY DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; DYSLIPIDEMIA; FEMALE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RETROSPECTIVE STUDY; RISK FACTOR; SMOKING; STROKE; WHITE MATTER; BRAIN; HEMISPHERIC DOMINANCE; IMAGE PROCESSING; METABOLISM; MIDDLE AGED; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PHYSIOLOGY; REFERENCE VALUE; STATISTICS;

ADULT; AGED; AGED, 80 AND OVER; ASPARTIC ACID; BRAIN; CHOLINE; CREATINE; DOMINANCE, CEREBRAL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INFARCTION, MIDDLE CEREBRAL ARTERY; LACTIC ACID; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; NEUROLOGIC EXAMINATION; REFERENCE VALUES; RETROSPECTIVE STUDIES; RISK FACTORS; STATISTICS;

EID: 33646932474     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp.2005.078238     Document Type: Article

References (24)

1. Special report from the National Institute of Neurological Disorders and Stroke. Classification of cerebrovascular disease III. Stroke 1990;21:637-76.
2. van den Boogaart A, Van Ormondt D, Pijnappel W, et al. Mathematics in signal processing. Oxford, UK: Clarendon Press, 1994:175.
3. Vanhamme L, van den Boogaart A, Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 1997;129(1):35-43.
4. Matthews V, Barker P, Blackband S, et al. Metabolites in patients with acute and subacute strokes: concentrations determined by quantitative proton MR spectroscopy. AJR Am J Roentgenol, 1995;165:633-8.
5. Kamba M, Inoue Y, Higami S, et al. Cerebral metabolic impairment in patients with obstructive sleep apnoea: an independent association of obstructive sleep apnoea with white matter change. J Neurol Neurosurg Psychiatry 2001;71(3):334-9.
6. Parsons MW, Barber PA, Desmond PM, et al. Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study. Ann Neurol 2002;52(1):20-8.
7. Bakker FC, Klijn CJ, van der Grond J, et al. Cognition and quality of life in patients with carotid artery occlusion: a follow-up study. Neurology 2004;62(12):2230-5.
8. Firbank MJ, Minett T, O'Brien JT. Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects. Neurology 2003;61(7):950-4.
9. Hund-Georgiadis M, Norris DG, Guthke T, et al. Characterization of cerebral small vessel disease by proton spectroscopy and morphological magnetic resonance. Cerebrovasc Dis 2001;12:82-90.
10. Capizzano AA, Schuff N, Amend DL, et al. Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and H-1 MR spectroscopy. Am J Neuroradiol 2000;21(4):621-30.
11. Schuff N, Capizzano AA, Du AT, et al. Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD. Neurology 2003;61(3):358-64.
12. Ben Salem D, Walker PM, Osseby GV, et al. Subcortical gray matter N-acetylaspartate reduction in two cases of vascular dementia. Clin Imaging 2003;27(1):14-17.
13. Sabri O, Ringelstein EB, Hellwig D, et al. Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy. Stroke 1999;30(3):556-66.
14. Kario K, Sakata T, Higashikawa M, et al. Silent cerebral infarcts in basal ganglia are advanced in congenital protein C-deficient heterozygotes with hypertension. Am J Hypertens 2001;14(8):818-22.
15. Mielke R, Kessler J, Szelies B, et al. Vascular dementia: perfusional and metabolic disturbances and effects of therapy. J Neurol Transm Suppl 1996;47:183-91.
16. Grachev ID, Swarnkar A, Szeverenyi NM, et al. Aging alters the multichemical networking profile of the human brain: an in vivo H-1-MRS study of young versus middle-aged subjects. J Neurochem 2001;77(1):292-303.
17. Grachev ID, Apkarian AV. Chemical heterogeneity of the living human brain: a proton MR spectroscopy study on the effects of sex, age, and brain region. Neuroimage 2000;11(5 Pt 1):554-63.
18. Angelie E, Bonmartin A, Boudraa A, et al. Regional differences and metabolic changes in normal aging of the human brain: proton MR spectroscopic imaging study. Am J Neuroradiol 2001;22(1):119-27.
19. Wilkinson ID, Paley MN, Miszkiel KA, et al. Cerebral volumes and spectroscopic proton metabolites on MR: is sex important? Magn Reson Imaging 1997;15(2):243-8.
20. Komoroski RA, Heimberg C, Cardwell D, et al. Effects of gender and region on proton MRS of normal human brain. Magn Reson Imaging 1999;17(3):427-33.
21. Pouwels PJ, Brockmann K, Kruse B, et al. Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS. Pediatr Res 1999;46(4):474-85.
22. Demougeot C, Walker P, Beley A, et al. Spectroscopic data following stroke reveal tissue abnormality beyond the region of T2-weighted hyperintensity. J Neurol Sci 2002;199(1-2):73-8.
23. Chu WJ, Mason GF, Pan JW, et al. Regional cerebral blood flow and magnetic resonance spectroscopic imaging findings in diaschisis from stroke. Stroke 2002;33(5):1243-8.
24. Fulham MJ, Dietz MJ, Duyn JH, et al. Transsynaptic reduction in N-acetylaspartate in cerebellar diaschisis: a proton MR spectroscopic imaging study. J Comput Assist Tomogr 1994;18(5):697-704.