Does testosterone mediate cognitive decline in elderly men?

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 61, Issue 5, 2006, Pages 521-

  Moffat, Scott D ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE;

AGING; COGNITION; COGNITIVE DEFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; HORMONE ACTION; HUMAN; LETTER; NEUROLOGIC EXAMINATION; PEER REVIEW; PRIORITY JOURNAL; SPATIAL MEMORY; TESTOSTERONE BLOOD LEVEL; VERBAL MEMORY; VISUAL MEMORY; WORKING MEMORY;

EID: 33646924811     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/61.5.521     Document Type: Letter

References (8)

1. Hogervorst E, Bandelow S, Combrinck M, Smith AD. Low free testosterone is an independent risk factor for Alzheimer's disease. Exp Gerontol. 2004;39:1633-1639.
2. Moffat SD, Zonderman AB, Metter EJ, et al. Free testosterone and risk for Alzheimer disease in older men. Neurology. 2004;62:188-193.
3. Moffat SD, Zonderman AB, Metter EJ, Blackman MR, Harman SM, Resnick SM. Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J Clin Endocrinol Metab. 2002;87:5001-5007.
4. Janowsky JS, Oviatt SK, Orwoll ES. Testosterone influences spatial cognition in older men. Behav Neurosci, 1994;108:325-332.
5. Janowsky JS, Chavez B, Orwoll E. Sex steroids modify working memory. J Cogn Neurosci. 2000;12:407-414.
6. Cherrier MM, Asthana S, Plymate S, et al. Testosterone supplementation improves spatial and verbal memory in healthy older men. Neurology. 2001;57:80-88.
7. Cherrier MM, Anawalt BD, Herbst KL, et al. Cognitive effects of short-term manipulation of serum sex steroids in healthy young men. J Clin Endocrinol Metab. 2002;87:3090-3096.
8. Cherrier MM, Matsumoto AM, Amory JK, et al. The role of aromatization in testosterone supplementation: effects on cognition in older men. Neurology. 2005;64:290-296.