Osteoporosis in children with severe congenital neutropenia: Bone mineral density and treatment with bisphosphonates

Journal of Pediatric Hematology/Oncology

Volumn 28, Issue 4, 2006, Pages 205-209

  Borzutzky, Arturo ^a   Reyes, María Loreto ^a   Figueroa, Valeria ^a   García, Cristián ^a   Cavieres, Mirta ^b  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b HOSPITAL LUIS CALVO MACKENNA   (Chile)

Author keywords

Bisphosphonates; Bone metabolism; Kostmann syndrome; Osteoporosis; Severe congenital neutropenia

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM; FOSVAL; GRANULOCYTE COLONY STIMULATING FACTOR; PAMIDRONIC ACID; VITAMIN D;

ABSENCE OF SIDE EFFECTS; ARTICLE; BONE DENSITY; CALCIUM INTAKE; CLINICAL ARTICLE; CLINICAL FEATURE; COMORBIDITY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; INFANT; MALE; NEUTROPENIA; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; PRESCHOOL CHILD; PRIORITY JOURNAL; TIME SERIES ANALYSIS; VERTEBRA FRACTURE; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CHILD; CHILD, PRESCHOOL; DIPHOSPHONATES; FEMALE; HUMANS; INCIDENCE; INFANT; MALE; MOTOR ACTIVITY; NEUTROPENIA; OSTEOPOROSIS; PROSPECTIVE STUDIES; SPINE; TREATMENT OUTCOME;

EID: 33646914982     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/01.mph.0000210409.48877.c3     Document Type: Article

References (20)

1. Kostmann R. Infantile genetic agranulocytosis. Acta Pediatr Scand. 1956;45:1-78.
2. Zeidler C, Welte K. Kostmann syndrome and severe congenital neutropenia. Semin Hematol. 2002;39:82-88.
3. Zeidler C, Boxer L, Dale DC, et al. Management of Kostmann syndrome in the G-CSF era. Br J Haematol. 2000;109:490-495.
4. Dale DC, Person RE, Bolyard AA, et al. Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood. 2000;96:2317-2322.
5. Yakisan E, Schirg E, Zeidler C, et al. High incidence of significant bone loss in patients with severe congenital neutropenia (Kostmann's syndrome). J Pediatr. 1997;131:592-597.
6. Dale DC, Cottle TE, Fier CJ, et al. Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry. Am J Hematol. 2003;72:82-93.
7. Sekhar RV, Culbert S, Hoots WK, et al. Severe osteopenia in a young boy with Kostmann's congenital neutropenia treated with granulocyte colony-stimulating factor: suggested therapeutic approach. Pediatrics. 2001;108:E54.
8. Batch JA, Couper JJ, Rodda C, et al. Use of bisphosphonate therapy for osteoporosis in childhood and adolescence. J Paediatr Child Health. 2003;39:88-92.
9. Glorieux FH, Bishop NJ, Plotkin H, et al. Cyclic administration of pamidronate in children with severe osteogenesis imperfecta. N Engl J Med. 1998;339:947-952.
10. Reyes ML, Hernandez MI, Urrejola P, et al. Normal values of biochemical and densitometric tests on bone metabolism in Chilean children. 2-18 year-old. Bone. 2005;36:S70-S71.
11. Lopez JM, Gonzalez G, Reyes V, et al. Bone turnover and density in healthy women during breastfeeding and after weaning. Osteoporos Int. 1996;6:153-159.
12. Manjon Llorente G, Fernandez-Espuelas C, Gonzalez Lopez JM, et al. Normal values of bone turnover markers in childhood. An Pediatr (Barcelona). 2004;60:330-336.
13. Lee MY, Fukunaga R, Lee TJ, et al. Bone modulation in sustained hematopoietic stimulation in mice. Blood. 1991;77:2135-2141.
14. Takahashi T, Wada T, Mori M, et al. Overexpression of the granulocyte colony-stimulating factor gene leads to osteoporosis in mice. Lab Invest. 1996;74:827-834.
15. Bishop NJ, Williams DM, Compston JC, et al. Osteoporosis in severe congenital neutropenia treated with granulocyte colony-stimulating factor. Br J Haematol. 1995;89:927-928.
16. Roodman GD. Advances in bone biology: the osteoclast. Endocr Rev. 1996;17:308-332.
17. Welte K, Zeidler C, Reiter A, et al. Differential effects of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in children with severe congenital neutropenia. Blood. 1990;75:1056-1063.
18. Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 2000;21:115-137.
19. Elhasid R, Hofbauer LC, Ish-Shalom S, et al. Familial severe congenital neutropenia associated with infantile osteoporosis: a new entity. Am J Hematol. 2003;72:34-37.
20. Whyte MP, Wenkert D, Clements KL, et al. Bisphosphonate-induced osteopetrosis. N Engl J Med. 2003;349:457-463.