Unusual type of TLS/FUS-ERG chimeric transcript in a pediatric acute myelocytic leukemia with 47,XX,+10,t(16;21)(p11;q22)

Cancer Genetics and Cytogenetics

Volumn 167, Issue 2, 2006, Pages 172-176

  Choi, Hyun Woo ^a   Shin, Myung Geun ^a   Sawyer, Jeffrey R ^b   Cho, Duck ^a   Kee, Seung Jung ^a   Baek, Hee Jo ^c   Kook, Hoon ^c   Kim, Hyeoung Joon ^a   Shin, Jong Hee ^a   Suh, Soon Pal ^a   Hwang, Tai Ju ^c   Ryang, Dong Wook ^a  

^a Chonnam National University Hwasun Hospital and Medical School   (South Korea)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c Chonnam National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID DERIVATIVE; CHIMERIC PROTEIN; CYTARABINE; ESTERASE; FLUDARABINE; IDARUBICIN; MYELOPEROXIDASE;

ACUTE GRANULOCYTIC LEUKEMIA; ANAMNESIS; ANTIGEN EXPRESSION; ARTICLE; CANCER CHEMOTHERAPY; CASE REPORT; CHIMERA; CHROMOSOME 16P; CHROMOSOME 21Q; CHROMOSOME TRANSLOCATION 16; CHROMOSOME TRANSLOCATION 21; CLINICAL FEATURE; ERYTHROPHAGOCYTOSIS; FEMALE; FUSION GENE; GENE FUSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; KARYOTYPING; LEUKEMIA CELL; PERIODIC ACID SCHIFF STAIN; PRESCHOOL CHILD; PRIORITY JOURNAL; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BONE MARROW CELLS; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 10; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 21; FEMALE; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA-BINDING PROTEIN FUS; SEQUENCE ANALYSIS, DNA; TRANSLOCATION, GENETIC; TRISOMY;

EID: 33646909887     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2006.01.003     Document Type: Article

References (16)

1. Ferro M.R., Cabello P., Garcia-Sagredo J.M., Resino M., San Roman C., and Larana J.G. t(16;21) in a Ph positive CML. Cancer Genet Cytogenet 60 (1992) 210-211
2. Imashuku S., Hibi S., Sako M., Lin Y.W., Ikuta K., Nakata Y., Mori T., Iizuka S., Horibe K., and Tsunematsu Y. Hemophagocytosis by leukemic blasts in 7 acute myeloid leukemia cases with t(16;21)(p11;q22): common morphologic characteristics for this type of leukemia. Cancer 88 (2000) 1970-1975
3. Sadamori N., Yao E., Tagawa M., Nakamura H., Sasagawa I., Itoyama T., Tokunaga S., Ichimaru M., Nakamura I., and Kamei T. 16;21 translocation in acute nonlymphocytic leukemia with abnormal eosinophils: a unique subtype. Acta Haematol 84 (1990) 212-216
4. Imashuku S., Hibi S., Kuriyama K., and Todo S. Hemophagocytosis by leukemic blasts in a case of acute megakaryoblastic leukemia with t(16;21)(p11;q22). Int J Hematol 70 (1999) 36-39
5. Handler E.S., Andler E.E., and Chesebrough A.B. Phagocytic activity of leukemic myeloblasts. J Reticuloendothel Soc 6 (1969) 511-524
6. Borrow J., Stanton Jr. V.P., Andresen J.M., Becher R., Behm F.G., Chaganti R.S., Civin C.I., Disteche C., Dube I., Frischauf A.M., Horsman D., Mitelman F., Volinia S., Watmore A.E., and Housman D.E. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet 14 (1996) 33-41
7. Velloso E.R., Mecucci C., Michaux L., Van Orshoven A., Stul M., Boogaerts M., Bosly A., Cassiman J.J., and Van Den B.H. Translocation t(8;16)(p11;p13) in acute non-lymphocytic leukemia: report on two new cases and review of the literature. Leuk Lymphoma 21 (1996) 137-142
8. Quesnel B., Kantarjian H., Bjergaard J.P., Brault P., Estey E., Lai J.L., Tilly H., Stoppa A.M., Archimbaud E., and Harousseau J.L. Therapy-related acute myeloid leukemia with t(8;21), inv(16), and t(8;16): a report on 25 cases and review of the literature. J Clin Oncol 11 (1993) 2370-2379
9. Coulthard S., Chase A., Orchard K., Watmore A., Vora A., Goldman J.M., and Swirsky D.M. Two cases of inv(8)(p11q13) in AML with erythrophagocytosis: a new cytogenetic variant. Br J Haematol 100 (1998) 561-563
10. Stark B., Resnitzky P., Jeison M., Luria D., Blau O., Avigad S., Shaft D., Kodman Y., Gobuzov R., and Ash S. A distinct subtype of M4/M5 acute myeloblastic leukemia (AML) associated with t(8;16)(p11;p13), in a patient with the variant t(8:19)(p11:q13)-case report and review of the literature. Leuk Res 19 (1995) 367-379
11. Kong X.T., Ida K., Ichikawa H., Shimizu K., Ohki M., Maseki N., Kaneko Y., Sako M., Kobayashi Y., Tojou A., Miura I., Kakuda H., Funabiki T., Horibe K., Hamaguchi H., Akiyama Y., Bessho F., Yanagisawa M., and Hayashi Y. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript. Blood 90 (1997) 1192-1199
12. Mitelman F. ISCN: An International System for Human Cytogenetic Nomenclature (1995), S. Karger, Basel
13. Perot C. t(16;21)(q24;q22). Atlas Genet Cytogenet Oncol Haematol. Available at: http://www.infobiogen.fr/services/chromcancer/Anomalies/t1621ID1123.html . Accessed April 1998.
14. Huret JL. t(16;21)(q24;q22). Atlas Genet Cytogenet Oncol Haematol. Available at: http://www.infobiogen.fr/services/chromcancer/Anomalies/t1621ID1123.html . Accessed August 2003.
15. Shing D.C., McMullan D.J., Roberts P., Smith K., Chin S.F., Nicholson J., Tillman R.M., Ramani P., Cullinane C., and Coleman N. FUS/ERG gene fusions in Ewing's tumors. Cancer Res 63 (2003) 4568-4576
16. Perrotti D., Bonatti S., Trotta R., Martinez R., Skorski T., Salomoni P., Grassilli E., Lozzo R.V., Cooper D.R., and Calabretta B. TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. EMBO J 17 (1998) 4442-4455