Comparison of the analgesic efficacy and safety of nepafenac ophthalmic suspension compared with diclofenac ophthalmic solution for ocular pain and photophobia after excimer laser surgery: A phase II, randomized, double-masked trial

Clinical Therapeutics

Volumn 28, Issue 4, 2006, Pages 527-536

  Colin, Joseph ^a   Paquette, Bertrand ^b  

^a HÔPITAL PELLEGRIN   (France)

^b ALCON RESEARCH LTD   (United States)

Author keywords

diclofenac; nepafenac; ophthalmic; pain; photophobia; PRK; refractive

Indexed keywords

DICLOFENAC; EYE DROPS; NEPAFENAC; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; UNCLASSIFIED DRUG;

ACCIDENTAL INJURY; ADULT; ANALGESIA; ANXIETY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORNEA DISEASE; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG INSTILLATION; DRUG SAFETY; EPITHELIZATION; EYE DISCOMFORT; EYE PAIN; FEMALE; FLU LIKE SYNDROME; HUMAN; MALE; PAIN ASSESSMENT; PERIOPERATIVE PERIOD; PHASE 2 CLINICAL TRIAL; PHOTOPHOBIA; PHOTOREFRACTIVE KERATECTOMY; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STATISTICAL SIGNIFICANCE; SURGICAL PATIENT; VISUAL ANALOG SCALE;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZENEACETAMIDES; DICLOFENAC; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KERATOTOMY, RADIAL; MALE; MIDDLE AGED; OPHTHALMIC SOLUTIONS; PAIN, POSTOPERATIVE; PHENYLACETATES; PHOTOPHOBIA; POSTOPERATIVE COMPLICATIONS; SUSPENSIONS;

EID: 33646894688     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2006.04.004     Document Type: Article

References (20)

1. Sher N.A., Frantz J.M., Talley A., et al. Topical diclofenac in the treatment of ocular pain after excimer photorefractive keratectomy. Refract Corneal Surg 9 (1993) 425-436
2. Cherry P.M., Tutton M.K., Adhikary H., et al. The treatment of pain following photorefractive keratectomy. J Refract Corneal Surg 10 Suppl 2 (1994) S222-S225
3. Stein R., Stein H.A., Cheskes A., and Symons S. Photorefractive keratectomy and postoperative pain. Am J Ophthalmol 117 (1994) 403-405
4. Algawi K., Agrell B., Goggin M., and O'Keefe M. Randomized clinical trial of topical sodium hyaluronate after excimer laser photorefractive keratectomy. J Refract Surg 11 (1995) 42-44
5. Tutton M.K., Cherry P.M., Raj P.S., and Fsadni M.G. Efficacy and safety of topical diclofenac in reducing ocular pain after exci mer photorefractive keratectomy. J Cataract Refract Surg 22 (1996) 536-541
6. Arshinoff S. The role of NSAIDs in ophthalmic laser procedures. In: Solomon L.D. (Ed). Proceedings of the Ophthalmic NSAID Roundtable at the American Academy of Ophthalmology's 96th Annual Meeting. Dallas, Texas, 1992 (1992), Medicopea International, Montreal, QC 63-72
7. Burke A., Smyth E., and FitzGerald G.A. Analgesic-antipyretic agents: Pharmacotherapyofgout. In: Brunton L.L., Lazo J.S., and Parker K.L. (Eds). Goodman & Gilman's The Pharmacological Basis ofTherapeutics. 11th ed. (2005), McGraw-Hill, New York, NY 671-715
8. McCormack K., and Brune K. Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacy. Drugs 41 (1991) 533-547
9. (Suppl). Arshinoff S., D'Addario D., Sadler C., et al. Use of topical nonsteroidal anti-inflammatory drugs in excimer laser photorefractive keratectomy. J Cataract Refract Surg 20 (1994) 216-222
10. Weinstock V.M., Weinstock D.J., and Weinstock S.J. Diclofenac and ketorolac in the treatment of pain after photorefractive keratectomy. J Refract Surg 12 (1996) 792-794
11. Ke T.L., Graff G., Spellman J.M., and Yanni J.M. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of traumainduced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation 24 (2000) 371-384
12. Zar J.H. Biostatistical Analysis. 3rd ed. (1996), Prentice Hall, Upper Saddle River, NJ
13. Badala F., Fioretto M., and Mach A. Effect of topical 0.1% indomethacin solution versus 0.1% fluorometholone acetate on ocular surface and pain control following laser subepithelial keratomileusis (LASEK). Cornea 23 (2004) 550-553
14. Rajpal R.K., Cooperman B.B., and Ketorolac Study Group. Analgesic efficacy and safety of ketorolac after photorefractive keratectomy. J Refract Surg 15 (1999) 661-667
15. Price Jr. F.W., Price M.O., Zeh W., and Dobbins K. Pain reduction after laser in situ keratomileusis with ketoro lac tromethamine ophthalmic solution 0.5%: A randomized, doublemasked, placebo-controlled trial. J Refract Surg 18 (2002) 140-144
16. Gamache D.A., Graff G., Brady M.T., et al. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation 24 (2000) 357-370
17. Kapin M.A., Yanni J.M., Brady M.T., et al. Inflammation-mediated retinal edema in the rabbit is inhibited by topical nepafenac. Inflammation 27 (2003) 281-291
18. Rome L.H., and Lands W.E. Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs. Proc Natl Acad Sci USA 72 (1975) 4863-4865
19. Fort Lauderdale, Fla. Acosta M.C., Luna C.L., Graff G., and Gallar J. Comparative effects of the nonsteroidal anti-inflammatory drug nepafenac on corneal sensory nerve fibers responding to chemical irritation. Abstract presented at: Association for Research in Vision and Ophthalmology Annual Meeting. April 30-May 4 (2006)
20. Rower S. Preoperative and postoperative medications used for cataract surgery. Curr Opin Ophthalmol 10 (1999) 29-35