HTLV-1 p12I protein sequences from South America: Truncated proteins and common genetic signatures

AIDS Research and Human Retroviruses

Volumn 22, Issue 5, 2006, Pages 466-469

  Iñiguez, Alena M ^a   Gastaldello, René ^b   Gallego, Sandra ^b   Otsuki, Koko ^a   Vicente, Ana Carolina P ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21; VIRUS DNA; ONCOPROTEIN;

AMINO ACID SEQUENCE; ARGENTINA; ARTICLE; BRAZIL; GENETIC MARKER; GENETIC VARIABILITY; HUMAN T CELL LEUKEMIA VIRUS 1; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTH AMERICA; STRAIN DIFFERENCE; VIRUS ISOLATION; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; GENETICS; HUMAN; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STOP CODON;

AMINO ACID SEQUENCE; CODON, TERMINATOR; COMPUTER SIMULATION; GENETIC MARKERS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS, VIRAL; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SOUTH AMERICA;

EID: 33646889298     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2006.22.466     Document Type: Article

References (15)

1. Guo HG, Wong-Stall F, and Gallo RC: Novel viral sequences related to human T-cell leukemia virus in T cells of a seropositive baboon. Science 1984;223:1195-1197.
2. Watanabe T, Seiki M, Tsujimoto H, et al.: Sequence homology of the simian retrovirus genome with human T-cell leukemia virus type I. Virology 1985;144:59-65.
3. Laurentino RV, Lopes IGL, Azevedo VN, et al.: Molecular characterization of hyman T-cell lymphotropic virus coinfecting human immunodeficiency virus 1 infected patients in the Amazon region of Brazil. Mem Inst Oswaldo Cruz 2005;100:371-376.
4. Santos SB, Porto AF, Muniz AL, et al.: Clinical and immunological consequences of human T cell leukemia virus type-I and Schistosoma mansoni co-infection. Mem Inst Oswaldo Curz 2004;99:121-126.
5. Meertens L, Shanmugam V, Gessain A, et al.: A novel, divergent simian T-cell lymphotropic virus type 3 in a wild-caught red-capped mangabey (Cercocebus torquatus torquatus) from Nigeria. J Gen Virol 2003;84:2723-2727.
6. Slattery JP, Franchini G, and Gessain A: Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses. Genome Res 1999;9:525-540.
7. Dekaban GA, Peters AA, Mulloy JC, et al.: The HTLV-I orfI protein is recognized by serum antibodies from naturally infected humans and experimentally infected rabbits. Virology 2000;274:86-93.
8. Saksena NK, Srinivasan A, Ge YC, et al.: Simian T cell leukemia virus type I from naturally infected feral monkeys from Central and West Africa encodes a 91-amino acid p12 (ORF-I) protein as opposed to a 99-amino acid protein encoded by HTLV type I from humans. AIDS Res Hum Retroviruses 1997;13:425-432.
9. Iñiguez AM, Otsuki K, Magalhães GP, et al.; Genetic markers on the HTLV-1 p12I protein sequences from Brazilian HAM/TSP patients and asymptomatic HTLV-1 carrier isolates. AIDS Res Hum Retroviruses 2005;21:580-582.
10. Saksena NK, Herve V, Sherman MP, et al.: Sequence and phylogenetic analyses of a new STLV-I from a naturally infected tantalus monkey from Central Africa. Virology 1993;192:312-320.
11. Furukawa Y, Usuku K, Izumo S, et al.: Human T cell lymphotropic virus type I (HTLV-I) p12I is dispensable for HTLV-I transmission and maintenance of infection in vivo. AIDS Res Hum Retroviruses 2005;20:1092-1099.
12. Franchini G: Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection. Blood 1995;86:3619-3639.
13. I protein greatly influences its stability. J Virol 1999;73:6460-6467.
14. Albrecht B and Lairmore MD: Critical role of human T-lymphotropic virus type 1 accessory proteins in viral replication and pathogenesis. Microbiol Mol Biol Rev 2002;66:396-406.
15. Kim SJ, Ding W, Albrecht B, et al.: A conserved calcineurin-binding motif in human T lymphotropic virus type 1 p12I functions to modulate nuclear factor of activated T cell activation. J Biol Chem 2003;278:15550-15557.