Systemic oxygen transport in rats artificially selected for running endurance

Respiratory Physiology and Neurobiology

Volumn 151, Issue 2-3, 2006, Pages 141-150

  Gonzalez, Norberto C ^a   Howlett, Richard A ^b   Henderson, Kyle K ^a   Koch, Lauren G ^c   Britton, Steve L ^c   Wagner, Harrieth E ^b   Favret, Fabrice ^a   Wagner, Peter D ^b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Artificial selection; Convective oygen delivery; Exercise capacity; Exercise endurance; Genetic determinants; Muscle capillary density; Muscle oxidative capacity; over(V O2max); Systemic oxygen transport; Tissue oxygen diffusion

Indexed keywords

CITRATE SYNTHASE;

ARTICLE; BIOCHEMISTRY; CAPILLARY DENSITY; CONDUCTANCE; ENDURANCE; ENVIRONMENT; EXERCISE; EXTRACTION; GASTROCNEMIUS MUSCLE; GENETICS; HYPOXIA; LOCOMOTION; LUNG GAS EXCHANGE; LUNG VENTILATION; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN DIFFUSION; OXYGEN TISSUE LEVEL; OXYGEN TRANSPORT; PRIORITY JOURNAL; RUNNING; SKELETAL MUSCLE; STRUCTURE ANALYSIS; TREADMILL EXERCISE;

ANIMALS; ANOXIA; BIOLOGICAL TRANSPORT; BREEDING; MODELS, ANIMAL; MUSCLE FIBERS; OXYGEN; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; PHYSICAL ENDURANCE; RATS; RUNNING;

EID: 33646870816     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2005.09.012     Document Type: Article

References (35)

1. Bassett D.R., and Howley E.T. Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med. Sci. Sports Exercise 32 (2000) 70-84
2. Blomqvist C.G., and Saltin B. Cardiovascular adaptations to physical training. Annu. Rev. Physiol. 45 (1983) 169-189
3. O2max) response to exercise training: results from the HERITAGE family study. J. Appl. Physiol. 87 (1999) 1003-1008
4. Bouchard C., Lesage R., Lortie G., Simoneau J.A., Hamel P., Boulay M.R., Perusse L., Theriault G., and Leblanc C. Aerobic performance in brothers, dizygotic and monozygotic twins. Med. Sci. Sports Exercise 18 (1986) 639-646
5. 2 uptake and its response to training in the HERITAGE family study. J. Appl. Physiol. 88 (2000) 551-559
6. Britton S.L., and Koch L.G. Animal models for complex traits of physical capacity. Exercise Sport Sci. Rev. 29 (2001) 7-14
7. Butler P.J., Woakes A.J., Smale K., Roberts C.A., Hillidge C.J., Snow D.H., and Marlin D.J. Respiratory and cardiovascular adjustments during exercise of increased intensity and during recovery in thoroughbred horses. J. Exp. Biol. 179 (1993) 159-180
8. Davies K.J.A., Maguire J.J., Brooks G.A., Dallman P.R., and Packer L. Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion. Am. J. Physiol. Endocrinol. Metab. 242 (1982) E418-E427
9. Davies K.J.A., Packer L., and Brooks G.A. Biochemical adaptations of mitochondria, muscle, and whole animal respiration to endurance training. Arc. Biochem. Biophys. 209 (1981) 539-541
10. Dempsey J.A., and Wagner P.D. Exercise-induced arterial hypoxemia. J. Appl. Physiol. 87 (1999) 1997-2006
11. O2 for maximum cytochrome turnover in muscle in situ. Am. J. Physiol. Heart Circ. Physiol. 252 (1987) H906-H915
12. Hartl D.L., and Clark A.G. Principles of Population Genetics (1988), Sinauer, Sunderland, MA
13. 2 uptake in rats selectively bred for exercise endurance. J. Appl. Physiol. 93 (2002) 1265-1274
14. Hepple R.T. Skeletal muscle: microcirculatory adaptation to metabolic demand. Med. Sci. Sports Exercise 32 (2000) 117-123
15. 2 diffusing capacity: evidence from muscle function in situ. J. Appl. Physiol. 88 (2000) 560-566
16. O2max) and the capillary supply to skeletal muscle. J. Appl. Physiol. 82 (1997) 1305-1310
17. Holloszy J.O., and Coyle E.F. Adaptations of skeletal muscle to endurance training and their metabolic consequences. J. Appl. Physiol. 56 (1984) 831-838
18. Hoppeler H., Howald H., Conley K., Lindstedt S.L., Claassen H., Vock P., and Weibel E.R. Endurance training in humans: aerobic capacity and structure of skeletal muscle. J. Appl. Physiol. 59 (1985) 320-327
19. 2 and substrate transport in mammals. J. Exp. Biol. 201 (1998) 1051-1064
20. Howlett R.A., Gonzalez N.C., Wagner H.E., Fu Z., Britton S.L., Koch S.L., and Wagner P.D. Skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance. J. Appl. Physiol. 94 (2003) 1682-1688
21. 2 transport in rats continue to diverge with further selective breeding for endurance running. FASEB J. 19 (2005) [abstract 936.2]
22. Kindig C.A., Gallatin L.L., Erickson H.H., Fedde M.R., and Poole D.C. cardiorespiratory impact of the nitric oxide synthase inhibitor L-NAME in the exercising horse. Respir. Physiol. 120 (2000) 151-166
23. Kirkton S.D., Howlett R.A., Gonzalez N.C., Britton S.L., Koch L.G., Wagner H.E., and Wagner P.D. Cardiovascular differences in rats selectively bred for endurance running capacity. FASEB J. 19 (2005) [abstract 936.3]
24. Klissouras V. Heritability of adaptive variation. J. Appl. Physiol. 31 (1971) 338-344
25. Koch L.G., and Britton S.L. Artificial selection for intrinsic aerobic endurance running capacity in rats. Physiol. Genomics 5 (2001) 45-52
26. Mathieu O., Krauer R., Hoppeler H., Gher P., Lindstedt S., Alexander R.M.N., Taylor C.R., and Weibel E.R. Design of the mammalian respiratory system. VIII. Scaling mitochondrial volume in skeletal muscle to body mass. Respir. Physiol. 44 (1981) 113-128
27. Mathieu-Costello O., Suarez R.K., and Hochachka P.W. Capillary-to-fiber geometry and mitochondrial density in hummingbird flight muscle. Respir. Physiol. 89 (1992) 113-132
28. Phillips S.M., Green H.J., Tarnopolsky M.A., Heigenhauser G.J.F., and Grant S.M. Progressive effect of endurance training on metabolic adaptations of skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 270 (1996) E265-E272
29. 2 uptake in hypoxia. Respir. Physiol. 46 (1981) 193-208
30. Poole D.C., and Mathieu-Costello O. Relationship between fiber capillarization and mitochondrial volume density in control and trained rat soleus and plantaris muscles. Microcirculation 3 (1996) 175-186
31. 2 transport. J. Clin. Invest. 96 (1995) 1916-1926
32. Saltin, B., Gollnick P.D., 1983. Skeletal muscle adaptability: significance for metabolism and performance. In: Handbook of Physiology: Skeletal Muscle. Bethesda, MD. Am. Physiol. Soc., Section 10, Chapter 19, pp. 555-632.
33. Swallow J.G., Garland T., Carter P.A., Zhan W.Z., and Sieck G.C. Effects of voluntary activity and genetic selection on aerobic capacity in house mice (mus domesticus). J. Appl. Physiol. 84 (1998) 69-76
34. Wagner P.D. An integrated view of the determinants of maximum oxygen uptake. In: Gonzalez N.C., and Fedde M.R. (Eds). Oxygen Transfer from Atmosphere to Tissue (1988), Plenum, New York 245-256
35. O2max. Respir. Physiol. 93 (1993) 221-237