Non-arteritic anterior ischemic optic neuropathy, erectile dysfunction drugs, and amiodarone: Is there a relationship?

Journal of Neuro-Ophthalmology

Volumn 26, Issue 1, 2006, Pages 1-3

  Fraunfelder, Frederick W ^a,c   Shults, Thomas ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b Legacy Good Samaritan Devers Memorial Eye Clinic   (United States)

^c or 97239 4197   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; CYCLIC GMP PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PIPERAZINE DERIVATIVE;

CARDIOVASCULAR DISEASE; DOSE RESPONSE; DRUG SAFETY; EDITORIAL; ERECTILE DYSFUNCTION; FOLLOW UP; HUMAN; ISCHEMIC OPTIC NEUROPATHY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; VISUAL SYSTEM; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; IMPOTENCE; MALE; NOTE; RISK FACTOR;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; AMIODARONE; HUMANS; IMPOTENCE; MALE; OPTIC NEUROPATHY, ISCHEMIC; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; RISK FACTORS;

EID: 33646852813     PISSN: 10708022     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wno.0000205622.45263.ad     Document Type: Editorial

References (17)

1. Pomeranz HD, Bhavsar AR. Nonarteritic ischemic optic neuropathy developing soon after use of sildenafil (Viagra): a report of seven new cases. J Neuroophthalmol 2005;25:9-13.
2. Hayreh SS. Erectile dysfunction drugs and non-arteritic anterior ischemic optic neuropathy: is there a cause and effect relationship? J Neuroophthalmol 2005;25:295-8.
3. Murphy MA, Murphy JF. Amiodarone and optic neuropathy: the heart of the matter. J Neuroophthalmol 2005;25:232-6.
4. Fraunfelder FT. The National Registry of Drug-Induced Ocular Side Effects. In: Inman WG, ed. Monitoring for Drug Safety. London: MTP Press; 1980:289.
5. Edwards R, Biriell C. Harmonisation in pharmacovigilance. Drug Saf 1994;10:93-102.
6. Egan RA, Fraunfelder FW. Viagra and anterior ischemic optic neuropathy. Arch Ophthalmol 2005;123:709-10.
7. Gruhn N, Fledelius HC. Unilateral optic neuropathy associated with sildenafil intake. Acta Ophthalmol Scand 2005;83:131-2.
8. Gandhi JS. Sildenafil-associated NAION. Ophthalmology 2003;110:1860-1.
9. Boshier A, Pambakian N, Shakir SA. A case of non-arteritic ischemic optic neuropathy (NAION) in a male patient taking Sildenafil. Int J Clin Pharmacol Ther 2002;40:422-3.
10. Dheer S, Rekhi GS, Merlyn S. Sildenafil associated anterior ischemic optic neuropathy. J Assoc Physicians India 2002;50:265.
11. Pomeranz HD, Smith KH, Hart WM, Egan RA. Sildenafil-associated non-arteritic anterior ischemic optic neuropathy. Ophthalmology 2002;109:584-7.
12. Cunningham AV, Smith KH. Anterior ischemic optic neuropathy associated with Viagra. J Neuroophthalmol 2002;21:22-5.
13. Egan R, Pomeranz H. Sildenafil (Viagra) associated anterior ischemic optic neuropathy. Arch Ophthalmol 2002;118:291-2.
14. National Registry of Drug Induced Ocular Side Effects. Available at: http://www.eyedrugregistry.com. [Accessed December 20, 2005].
15. Fraunfelder FW. An overview of visual side effects associated with erectile dysfunction agents. Am J Ophthalmol 2005;140:723-4.
16. Lee AG, Newman NJ. Erectile dysfunction drugs and nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 2005;140:707-8.
17. Viagra®. In: Physicians' Desk Reference, 60th ed. Montvale, NJ: Thomson PDR; 2006:2552-6.