Investigation of the glidant properties of compacted colloidal silicon dioxide by angle of repose and X-ray photoelectron spectroscopy

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 63, Issue 3, 2006, Pages 356-359

  Jonat, Stéphane ^a   Albers, Peter ^b   Gray, Ann ^c   Schmidt, Peter C ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b AQura GmbH   (Germany)

^c EVONIK INDUSTRIES AG   (Germany)

Author keywords

Angle of repose; Colloidal silicon dioxide; Excipient; Mixing process; X ray photoelectron spectroscopy

Indexed keywords

AEROSIL; EXCIPIENT; HYDROXYL GROUP; MICROCRYSTALLINE CELLULOSE; SILICON DIOXIDE; STARCH;

ARTICLE; DENSITY; DRUG MIXTURE; FLOW MEASUREMENT; HYDROGEN BOND; HYDROPHILICITY; MORPHOLOGY; PARTICLE SIZE; SURFACE PROPERTY; X RAY PHOTOELECTRON SPECTROSCOPY;

CELLULOSE; COLLOIDS; EXCIPIENTS; SILICON DIOXIDE; SPECTROMETRY, X-RAY EMISSION; STARCH; SURFACE PROPERTIES;

EID: 33646840116     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.11.005     Document Type: Article

References (11)

1. Jonat S., Hasenzahl S., Drechsler M., Albers P., Wagner K.G., and Schmidt P.C. Investigation of compacted hydrophilic and hydrophobic colloidal silicon dioxides as glidants for pharmaceutical excipients. Powder Technol. 141 (2004) 31-43
2. Jonat S., Hasenzahl S., Gray A., and Schmidt P.C. Mechanism of glidants: investigation of the effect of different colloidal silicon dioxide types on powder flow by atomic force and scanning electron microscopy. J. Pharm. Sci. 93 (2004) 2635-2644
3. DIN ISO 4324, Pulver und Granulate, Bestimmung des Schüttwinkels (1983) 1-4.
4. European Pharmacopoeia, fifth Ed. Specific Surface Area by Gas Absorption, 2005, pp. 260-263.
5. Albers P., Seibold K., Haas T., Prescher G., and Hölderich W.F. SIMS/XPS study on the deactivation and reactivation of B-MFI catalysts used in the vapour-phase Beckmann rearrangement. J. Catal. 176 (1998) 561-568
6. Zimmermann I., Eber M., and Meyer K. Nanomaterials as flow regulators in dry powders. Z. Phys. Chem. 218 (2004) 51-102
7. Rumpf H. Die Wissenschaft des Agglomierens. Chem.-Ing.-Tech. 46 (1974) 1-11
8. Bolhuis G., and Chowan Z. Materials for direct compaction. In: Alderborn G., and Nyström C. (Eds). Pharmaceutical Powder Compaction Technology (1996), Marcel Dekker, New York, Basel 428-440
9. Beamson G., and Briggs D. High Resolution XPS of Organic Polymers (1992), Wiley, Chichester p. 158
10. Tänzer W. Biologisch abbaubare Polymere (2000), Wiley-VCH, Stuttgart, Germany pp. 56-73
11. Ammon H.T. Hunnius Pharmazeutisches wörterbuch. ninth ed. (2004), W. de Gruyter, New York, Berlin pp. 82-84