Psychiatric comorbidity and progression in drug use in adult male twins: Implications for the design of genetic association studies

Addictive Behaviors

Volumn 31, Issue 6, 2006, Pages 948-961

  Todorov, Alexandre A ^a   Lynskey, Michael T ^a   Grant, Julia D ^a   Scherrer, Jeffrey F ^a,b   Todd, Richard D ^a   Bucholz, Kathleen Keenan ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alcohol use disorder; Genetic association study; Psychiatric co morbidity; Substance use disorder

Indexed keywords

ALCOHOL; CANNABIS; CENTRAL STIMULANT AGENT; COCAINE; OPIATE; PSYCHEDELIC AGENT; SEDATIVE AGENT;

ADULT; ARTICLE; COMORBIDITY; CONTROLLED STUDY; DEPRESSION; DRUG DEPENDENCE; DRUG USE; GENETIC ASSOCIATION; HUMAN; MALE; PREVALENCE; PSYCHOPATHY; SUBSTANCE ABUSE; TOBACCO;

ADULT; DIAGNOSIS, DUAL (PSYCHIATRY); DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE PROGRESSION; DISEASES IN TWINS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MENTAL DISORDERS; MIDDLE AGED; MODELS, STATISTICAL; PATIENT SELECTION; PHENOTYPE; SUBSTANCE-RELATED DISORDERS;

EID: 33646839826     PISSN: 03064603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addbeh.2006.03.046     Document Type: Article

References (66)

1. Bienvenu O.J., Nestadt G., Samuels J.F., Costa P.T., Howard W.T., and Eaton W.W. Phobic, panic, and major depressive disorders and the five-factor model of personality. Journal of Nervous and Mental Disease 189 (2001) 154-161
2. Biernacki C., Celeux G., and Govaert G. Assessing a mixture model for clustering with the integrated classification likelihood. Annals of Statistics 26 (1998) 1614-1635
3. Cadoret R.J., Troughton E., O'Gorman T.W., and Heywood E. An adoption study of genetic and environmental factors in drug abuse. Archives of General Psychiatry 43 (1986) 1131-1136
4. Cadoret R.J., Yates W.R., Troughton E., Woodworth G., and Stewart M.A. Adoption study demonstrating two genetic pathways to drug abuse. Archives of General Psychiatry 52 (1995) 42-52
5. Cadoret R.J., Yates W.R., Troughton E., Woodworth G., and Stewart M.A. An adoption study of drug abuse/dependency in females. Comprehensive Psychiatry 37 (1996) 88-94
6. Chantarujikapong S.I., Scherrer J.F., Xian H., Eisen S.A., Lyons M.J., Goldberg J., et al. A twin study of generalized anxiety disorder symptoms, panic disorder symptoms and post-traumatic stress disorder in men. Psychiatry Research 103 (2001) 133-145
7. Clark L.A., Watson D., and Mineka S. Temperament, personality, and the mood and anxiety disorders. Journal of Abnormal Psychology 103 (1994) 103-116
8. Conway K.P., Kane R.J., Ball S.A., Poling J.C., and Rounsaville B.J. Personality, substance of choice, and polysubstance involvement among substance dependent patients. Drug and Alcohol Dependence 71 (2003) 65-75
9. Eisen S., Neuman R., Goldberg J., Rice J., and True W. Determining zygosity in the Vietnam Era Twin Registry: An approach using questionnaires. Clinical Genetics 35 (1989) 423-434
10. Eisen S., True W., Goldberg J., Henderson W., and Robinette C.D. The Vietnam Era Twin (VET) Registry: Method of construction. Acta Geneticae Medicae et Gemellologiae 36 (1987) 61-66
11. In: Glantz, and Pickens (Eds). Vulnerability to drug abuse (1992), American Psychological Association, Washington, DC 149-178
12. Grant B.F. Comorbidity between DSM-IV drug use disorders and major depression: Results of a national survey of adults. Journal of Substance Abuse 7 (1995) 481-497
13. Grant B.F., and Harford T.C. Comorbidity between DSM-IV alcohol use disorders and major depression: Results of a national study. Drug and Alcohol Dependence 39 (1995) 197-206
14. Helzer J.E., and Pryzbeck T.R. The co-occurrence of alcoholism with other psychiatric disorders in the general population and its impact on treatment. Journal of Studies on Alcohol 49 (1988) 219-224
15. Henderson W.G., Eisen S., Goldberg J., True W.R., Barnes J.E., and Vitek M.E. The Vietnam Era Twin Registry: A resource for medical research. Public Health Reports 105 (1990) 368-373
16. Hill S.Y., Cloninger R., and Ayre F.R. Independent familial transmission of alcoholism and opiate abuse. Alcoholism, Clinical and Experimental Research 1 (1977) 335-342
17. Hopfer C.J., Khuri E., Crowley T.J., and Hooks S. Adolescent heroin use: A review of the descriptive and treatment literature. Journal of Substance Abuse Treatment 23 (2002) 231-237
18. Jang K.L., Livesley W.J., and Vernon P.A. Alcohol and drug problems: A multivariate behavioural genetic analysis of co-morbidity. Addiction 90 (1995) 1213-1221
19. Kaye S., and Darke S. A comparison of the harms associated with the injection of heroin and amphetamines. Drug and Alcohol Dependence 58 (2000) 189-195
20. Kendler K.S., Karkowski L.M., Corey L.A., Prescott C.A., and Neale M.C. Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women. British Journal of Psychiatry (1999) 351-356
21. Kendler K.S., Jacobson K.C., Prescott C.A., and Neale M.C. Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. American Journal of Psychiatry 160 (2003) 687-695
22. Kendler K.S., Prescott C.A., Myers J., and Neale M.C. The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Archives of General Psychiatry 60 (2003) 929-937
23. Kessler R.C., Crum R.M., Warner L.A., Nelson C.B., Schulenberg J., and Anthony J.C. Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Archives of General Psychiatry 54 (1997) 313-321
24. Khan A.A., Jacobson K.C., Gardner C.O., Prescott C.A., and Kendler K.S. Personality and comorbidity of common psychiatric disorders. British Journal of Psychiatry 186 (2005) 190-196
25. Kosten T., Rounsaville B., and Kleber H.A. 2.5 year follow-up of abstinence and relapse to cocaine abuse in opioid addicts. NIDA Research Monograph 81 (1998) 231-236
26. Kreek M.J., Bart G., Lilly C., LaForge K.S., and Nielsen D.A. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacological Reviews 57 1 (2005, Mar.) 1-26
27. Krueger R.F. Continuity of axes I and II: Toward a unified model of personality, personality disorders, and clinical disorders. Journal of Personality Disorders 19 (2005) 233-261
28. Langbehn D.R., Cadoret R.J., Caspers K., Troughton E.P., and Yucuis R. Genetic and environmental risk factors for the onset of drug use and problems in adoptees. Drug and Alcohol Dependence 69 2 (2003, Mar. 1) 151-167
29. Lauzon P., Vincelette J., Bruneau J., Lamothe F., Lachance N., Brabant M., et al. Illicit use of methadone among i.v. drug users in Montreal. Journal of Substance Abuse Treatment 11 5 (1994, Sep.-Oct.) 457-461
30. Luthar S.S., Anton S.F., Merikangas K.R., and Rounsaville B.J. Vulnerability to drug abuse among opioid addicts' siblings: Individuals, familial, and peer influences. Comprehensive Psychiatry 33 (1992) 190-196
31. Luthar S.S., Anton S.F., Merikangas K.R., and Rounsaville B.J. Vulnerability of substance abuse and psychopathology among siblings of opioid abusers. The Journal of Nervous and Mental Disease 180 (1992) 153-161
32. Maddux J., and Desmond D. Family and environment in choice of opioid dependence or alcoholism. American Journal of Drug and Alcohol Abuse 15 (1989) 117-134
33. Markon K.E., and Krueger R.F. Categorical and continuous models of liability to externalizing disorders. Archives of General Psychiatry 62 (2005) 1352-1359
34. McCutcheon A.C. Latent Class Analysis (1987), Sage Publications, Beverly Hills
35. McGue M., Elkins I., and lacono W.G. Genetic and environmental influences on adolescent substance use and abuse. American Journal of Medical Genetics 96 (2000) 671-677
36. Merikangas K.R., Mehta R.L., Molnar B.E., Walters E.E., Swendsen J.D., Aguilar-Gaziola S., et al. Comorbidity of substance use disorders with mood and anxiety disorders: Results of the international consortium in psychiatric epidemiology. Addictive Behaviors 23 (1998) 893-907
37. Merikangas K.R., Risch N.J., and Weissman M.M. Comorbidity and co-transmission of alcoholism, anxiety and depression. Psychological Medicine 24 (1994) 69-80
38. Merikangas K.R., Rounsaville B.J., and Prusoff B.A. Familial factors in vulnerability to substance abuse. In: Glantz M.D., and Pickens R. (Eds). Vulnerability to Drug Abuse (1992), American Psychological Association, Washington, DC 75-98
39. Merikangas K.R., Stolar M., Stevens D.E., Goulet J., Preisig M.A., Fenton B., et al. Familial transmission of substance use disorders. Archives of General Psychiatry 55 (1998) 973-979
40. Myrick H., and Brady K.T. Social phobia in cocaine-dependent individuals. American Journal on Addictions 6 2 (1997) 99-104
41. Newlin D.B., Miles D.R., van den Bree M.B.M., Gupman A.E., and Pickens R.W. Environmental transmission of DSM-IV substance use disorders in adoptive and step families. Alcoholism, Clinical and Experimental Research 24 (2000) 1785-1794
42. Nurnberger J.I., Wiegand R., Bucholz K.K., O'Connor S., Meyer E.T., Reich T., et al. A family study of alcohol dependence: Coaggregation of multiple disorders in relatives of alcohol-dependent probands. Archives of General Psychiatry 61 (2004) 1246-1256
43. Pickens R.W., Preston K.L., Miles D.R., Gupman A.E., Johnson E.O., Newlin D.B., et al. Family history influence on drug abuse severity and treatment outcome. Drug and Alcohol Dependence 61 3 (2001, Feb. 1) 261-270
44. Prescott C.A., and Kendler K.S. Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. American Journal of Psychiatry 156 (1999) 34-40
45. Regier D.A., Farmer M.E., Rae D.S., Locke B.Z., Keith S.J., Judd L.L., et al. Comorbidity of mental disorders with alcohol and other drug abuse: Results from the Epidemiologic Catchment Area (ECA) Study. Journal of the American Medical Association 264 (1990) 2511-2518
46. Rhee S.H., Hewitt J.K., Young S.E., Corley R.P., Crowley T.J., and Stallings M.C. Genetic and environmental influences on substance initiation, use, and problem use in adolescents. Archives of General Psychiatry 60 (2003) 1256-1264
47. Robins, L. N., Helzer, J. E., Cottler, L. B., & Goldring, E. (1989). National Institute of Mental Health Diagnostic Interview Schedule Version III Revised.
48. Robins L.N., Helzer J.E., Croughan J.L., and Ratcliff K.S. The NIMH Diagnostic Interview Schedule: Its history, characteristics and validity. Archives of General Psychiatry 38 (1981) 381-389
49. Robins L.N., Helzer J.E., Orvaschel H., Anthony J.C., Blazer D.G., Burnam A., et al. The Diagnostic Interview Schedule. In: Eaton W.W., and Kessler L.G. (Eds). Epidemiologic field methods in psychiatry: The NIMH Epidemiologic Catchment Area Program (1985), Academic Press, Toronto 143-170
50. Robins L.N., Helzer J.R., Ratcliff K.S., and Seyfried W. Validity of the Diagnostic Interview Schedule, version II: DSM-III diagnoses. Psychological Medicine 12 (1982) 855-870
51. Rounsaville B.J., Kosten T.R., Weissman M.M., Prusoff B., Pauls D., Anton S.F., et al. Psychiatric disorders in relatives of probands with opiate addiction. Archives of General Psychiatry 48 (1991) 33-42
52. Rounsaville B.J., Kosten T.R., Weissman M.M., Prusoff B.A., Pauls D., Anton S.F., et al. Psychiatric disorders in relatives of probands with opiate addiction. Archives of General Psychiatry 48 (1991) 2-33
53. Rounsaville B.J., Kranzler H.R., Ball S., Tennen H., Poling J., and Triffleman E. Personality disorders in substance abusers: Relation to substance use. Journal of Nervous and Mental Disease 186 (1998) 87-95
54. Scherrer J.F., True W.R., Xian J., Lyons M.J., Eisen S.A., Goldberg J., et al. Evidence for genetic influences common and specific to symptoms of generalized anxiety and panic. Journal of Affective Disorders 57 (2000) 25
55. Sher K.J., and Trull T.J. Personality and disinhibitory psychopathology: Alcoholism and antisocial personality disorder. Journal of Abnormal Psychology 103 (1994) 92-102
56. Stallings M.C., Corley R.P., Dennehey B., Hewitt J.K., Krauter K.S., Lessem J.M., et al. A genome-wide search for quantitative trait Loci that influence antisocial drug dependence in adolescence. Archives of General Psychiatry 62 9 (2005, Sep.) 1042-1051
57. Swendsen J.D., Merikangas K.R., Canino G.J., Kessler R.C., Rubio-Stipec M., and Angst J. The comorbidity of alcoholism with anxiety and depressive disorders in four geographic communities. Comprehensive Psychiatry 39 (1998) 176-184
58. Todd R.D. Genetic advances in autism hinge on the method of measuring symptoms. Current Psychiatry Reports 7 (2005) 133-137
59. Tomasson K., and Vaglum P. The role of psychiatric comorbidity in the prediction of readmission for detoxification. Comprehensive Psychiatry 39 3 (1998, May-Jun.) 129-136
60. Tomasson K., and Vaglum P. Social consequences of substance abuse: The impact of comorbid psychiatric disorders. A prospective study of a nation-wide sample of treatment-seeking patients. Scandinavian Journal of Social Medicine 26 1 (1998, Mar.) 63-70
61. Tsuang M.T., Lyons M.J., Meyer J.M., Doyle T., Eisen S.A., Goldberg J., et al. Co-occurrence of abuse of different drugs in men: The role of drug-specific and shared vulnerabilities. Archives of General Psychiatry 55 (1998) 967-972
62. Uhl G.R., Li Q.-R., Walther D., Hess J., and Naiman D. Polysubstance abuse-vulnerability genes: Genome scans for association, using 1004 subjects and 1494 single-nucleotide polymorphisms. American Journal of Human Genetics 69 (2001) 1290-1300
63. Uhl G.R., Liu Q.R., and Naiman D. Substance abuse vulnerability loci: Converging genome scanning data. Trends in Genetics 18 (2002) 420-425
64. Ulzen T.P., and Hamilton H. The nature and characteristics of psychiatric comorbidity in incarcerated adolescents. Canadian Journal of Psychiatry 43 1 (1998, Feb.) 57-63
65. van den Bree M.B.M., Johnson E.G., Neale M.C., and Pickens R.W. Genetic and environmental influences on drug use and abuse/dependence in male and female twins. Drug and Alcohol Dependence 52 (1998) 231-241
66. Vanyukov M.M., Tarter R.E., Kirisci L., Kirillova G.P., Maher B.S., and Clark D.B. Liability to substance use disorders: Common mechanisms and manifestations. Neuroscience and Biobehavioral Reviews 27 6 (2003, Oct.) 507-515