Effect of different nuclear localization sequences on the immune responses induced by a MIDGE vector encoding bovine herpesvirus-1 glycoprotein D

Vaccine

Volumn 24, Issue 21, 2006, Pages 4625-4629

  Zheng, Chunfu ^a   Juhls, Christiane ^b   Oswald, Detlef ^b   Sack, Florian ^b   Westfehling, Ines ^b   Wittig, Burghardt ^b,c   Babiuk, Lorne A ^a   Hurk, Sylvia van Drunen Littel van den ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b MOLOGEN AG   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

MIDGE; NLS; tgD

Indexed keywords

GLYCOPROTEIN D; VIRUS VECTOR;

ARTICLE; CELLULAR IMMUNITY; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, VIRAL; GENETIC VECTORS; HERPESVIRUS 1, BOVINE; IMMUNITY, CELLULAR; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; VIRAL PROTEINS;

EID: 33646838446     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2005.08.046     Document Type: Article

References (26)

1. Donnelly J.J., Ulmer J.B., Shiver J.W., and Liu M.A. DNA vaccines. Annu Rev Immunol 15 (1997) 617-648
2. Gurunathan S., Klinman D.M., and Seder R.A. DNA vaccines: immunology, application, and optimization. Annu Rev Immunol 18 (2000) 927-974
3. Donnelly J., Berry K., and Ulmer J.B. Technical and regulatory hurdles for DNA vaccines. Int J Parasitol 33 5-6 (2003) 457-467
4. Montgomery D.L., Donnelly J.J., Shiver J.W., Liu M.A., and Ulmer J.B. Protein expression in vivo by injection of polynucleotides. Curr Opin Biotechnol 5 5 (1994) 505-510
5. Cartier R., and Reszka R. Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems. Gene Ther 9 3 (2002) 157-167
6. Branden L.J., Mohamed A.J., and Smith C.I. A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA. Nat Biotechnol 17 8 (1999) 784-787
7. Ludtke J.J., Zhang G., Sebestyen M.G., and Wolff J.A. A nuclear localization signal can enhance both the nuclear transport and expression of 1 kb DNA. J Cell Sci 112 Part 12 (1999) 2033-2041
8. Zanta M.A., Belguise-Valladier P., and Behr J.P. Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci USA 96 1 (1999) 91-96
9. Jung D., Jaeger E., Cayeux S., et al. Strong immunogenic potential of a B7 retroviral expression vector: generation of HLA-B7-restricted CTL response against selectable marker genes. Hum Gene Ther 9 1 (1998) 53-62
10. Boretti F.S., Leutenegger C.M., Mislin C., et al. Protection against FIV challenge infection by genetic vaccination using minimalistic DNA constructs for FIV env gene and feline IL-12 expression. AIDS 14 12 (2000) 1749-1757
11. Schirmbeck R., Fissolo N., Chaplin P., and Reimann J. Enhanced priming of multispecific, murine CD8+ T cell responses by DNA vaccines expressing stress protein-binding polytope peptides. J Immunol 171 3 (2003) 1240-1246
12. Braun R.P., Babiuk L.A., Loehr B.I., and van Drunen Littel-van den H. Particle-mediated DNA immunization of cattle confers long-lasting immunity against bovine herpesvirus-1. Virology 265 1 (1999) 46-56
13. van Drunen Littel-van den H., Braun R.P., Lewis P.J., et al. Intradermal immunization with a bovine herpesvirus-1 DNA vaccine induces protective immunity in cattle. J Gen Virol 79 Part 4 (1998) 831-839
14. Adam S.A., and Gerace L. Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import. Cell 66 5 (1991) 837-847
15. Zheng C., Brownlie R., Babiuk L.A., and van Drunen Littel-van den Hurk S. Characterization of nuclear localization and export signals of the major tegument protein VP8 of bovine herpesvirus-1. Virology 324 2 (2004) 327-339
16. Elliott G., and O'Hare P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88 2 (1997) 223-233
17. Schirmbeck R., Konig-Merediz S.A., Riedl P., et al. Priming of immune responses to hepatitis B surface antigen with minimal DNA expression constructs modified with a nuclear localization signal peptide. J Mol Med 79 5-6 (2001) 343-350
18. Pontarollo R.A., Babiuk L.A., Hecker R., and Van Drunen Littel-Van Den Hurk S. Augmentation of cellular immune responses to bovine herpesvirus-1 glycoprotein D by vaccination with CpG-enhanced plasmid vectors. J Gen Virol 83 Part 12 (2001) 2973-2981
19. Boutorine A.S., and Kostina E.V. Reversible covalent attachment of cholesterol to oligodeoxyribonucleotides for studies of the mechanisms of their penetration into eucaryotic cells. Biochimie 75 1-2 (1993) 35-41
20. Jans D.A., Chan C.K., and Huebner S. Signals mediating nuclear targeting and their regulation: application in drug delivery. Med Res Rev 18 4 (1998) 189-223
21. Newmeyer D.D., and Forbes D.J. Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation. Cell 52 5 (1988) 641-653
22. Leutenegger C.M., Boretti F.S., Mislin C.N., Flynn J.N., Schroff M., Habel A., et al. Immunization of cats against feline immunodeficiency virus (FIV) infection by using minimalistic immunogenic defined gene expression vector vaccines expressing FIV gp140 alone or with feline interleukin-12 (IL-12), IL-16, or a CpG motif. J Virol 74 22 (2000) 10447-10457
23. Lopez-Fuertes L., Perez-Jimenez E., Vila-Coro A.J., Sack F., Moreno S., Konig S.A., et al. DNA vaccination with linear minimalistic (MIDGE) vectors confers protection against Leishmania major infection in mice. Vaccine 21 3-4 (2002) 247-257
24. Moreno S., Lopez-Fuertes L., Vila-Coro A.J., Sack F., Smith C.A., Konig S.A., et al. DNA immunisation with minimalistic expression constructs. Vaccine 22 13-14 (2004) 1709-1716
25. van den Hurk J.V., and van Drunen Littel-van den Hurk S. Protection of turkeys against haemorrhagic enteritis by monoclonal antibody and hexon immunization. Vaccine 11 3 (1993) 329-335
26. Manoj S., Babiuk L.A., and van Drunen Littel-van den Hurk S. Immunization with a dicistronic plasmid expressing a truncated form of bovine herpesvirus-1 glycoprotein D and the amino-terminal subunit of glycoprotein B results in reduced gB-specific immune responses. Virology 313 1 (2003) 296-307