Lysine sulfonamides as novel HIV-protease inhibitors: Nε-Acyl aromatic α-amino acids

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3459-3462

  Stranix, Brent R ^a   Lavallée, Jean François ^a   Sévigny, Guy ^a   Yelle, Jocelyn ^a   Perron, Valérie ^a   LeBerre, Nicholas ^a   Herbart, Dominik ^a   Wu, Jinzi J ^a  

^a Ambrilia Biopharma Inc   (Canada)

Author keywords

Amino acids; HIV protease inhibitor; Lysine; Resistant viral strains

Indexed keywords

ALPHA AMINO CAPROLACTAM; AMINO ACID DERIVATIVE; ASPARTIC PROTEINASE; LACTAM DERIVATIVE; LYSINE SULFONAMIDE DERIVATIVE; N EPSILON ACYL AROMATIC ALPHA AMINO ACID DERIVATIVE; PROTEINASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; WILD TYPE;

ACYLATION; AMINO ACIDS; ANTI-HIV AGENTS; CELL LINE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HIV; HIV PROTEASE INHIBITORS; HUMANS; LYSINE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 33646837320     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.011     Document Type: Article

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