A novel DNA damage recognition protein in Schizosaccharomyces pombe

Nucleic Acids Research

Volumn 34, Issue 8, 2006, Pages 2347-2354

  Pearson, Steven J ^a   Wharton, Stephen ^a   Watson, Amanda J ^a   Begum, Ghazala ^a   Butt, Amna ^a   Glynn, Nicola ^a   Williams, David M ^b   Shibata, Takayuki ^b   Santibáñez Koref, Mauro F ^c   Margison, Geoffrey P ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; BUTYLNITROSOUREA; ETHYLNITROSOUREA; MESYLIC ACID ETHYL ESTER; MESYLIC ACID METHYL ESTER; METHYLNITRONITROSOGUANIDINE; METHYLNITROSOUREA; OLIGONUCLEOTIDE; ALKYLATING AGENT; ATL1 PROTEIN, S POMBE; DNA BINDING PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; SCHIZOSACCHAROMYCES POMBE PROTEIN; TRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA ISOLATION; DNA REPAIR; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GROWTH INHIBITION; INCUBATION TIME; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; SCHIZOSACCHAROMYCES POMBE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; CHEMISTRY; DRUG EFFECT; GENETICS; METABOLISM; SCHIZOSACCHAROMYCES;

EUKARYOTA; PROKARYOTA; SCHIZOSACCHAROMYCES POMBE;

ALKYL AND ARYL TRANSFERASES; ALKYLATING AGENTS; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GENE DELETION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OLIGONUCLEOTIDES; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

EID: 33646825661     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl270     Document Type: Article

References (28)

1. Friedberg,E.C. (2003) DNA damage and repair. Nature, 421, 436-440.
2. Saffhill,R., Margison,G.P. and O'Connor,P.J. (1985) Mechanisms of carcinogenesis by alkylating agents. Biochem. Biophys. Acta., 832, 111-145.
3. Beranek,D.T. (1990) Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents. Mutat. Res., 231, 11-30.
4. Kaina,B., Ochs,K., Grosch,S., Fritz,G., Lips,J., Tomicic,M., Dunkern,T. and Christmann,M. (2001) BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis. Prog. Nucleic Acid Res. Mol. Biol., 68, 41-54.
5. 6-methylguanine. Mutagenesis, 17, 483-487.
6. 6-alkylguanine. Proc. Natl Acad. Sci. USA, 87, 686-690.
7. 6-alkylguanine by alkyltransferases. Mutat. Res., 462, 83-100.
8. 6-alkylguanine-DNA alkyltransferase: Role in carcinogenesis and chemotherapy. Bioessays, 24, 255-266.
9. 6-alkylguanine-DNA alkyltransferase. Carcinogenesis, 24, 625-635.
10. 6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli. Nucleic Acids Res., 33, 3837-3844.
11. Marchler-Bauer,A., Anderson,J.B., Cherukuri,P.F., DeWeese-Scott,C., Geer,L.Y., Gwadz,M., He,S., Hurwitz,D.I., Jackson,J.D., Ke,Z. et al. (2005) CDD: A Conserved Domain Database for protein classification. Nucleic Acids Res., 33, D192-D196.
12. Demple,B., Sedgwick,B., Robins,P., Totty,N., Waterfield,M.D. and Lindahl,T. (1985) Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis. Proc. Natl Acad. Sci. USA, 82, 2688-2692.
13. 6-alkylguanine-DNA-alkyltransferase gene of E. coli. Nucleic Acids Res., 15, 9177-9193.
14. Memisoglu,A. and Samson,L. (2000) Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe. J. Bacteriol., 182, 2104-2112.
15. Fronza,G. and Gold,B. (2004) The biological effects of N3-methyladenine. J. Cell Biochem., 91, 250-257.
16. Connor,E.E., Wilson,J.J. and Wyatt,M.D. (2005) Effects of substrate specificity on initiating the base excision repair of N-methylpurines by variant human 3-methyladenine DNA glycosylases. Chem. Res. Toxicol., 18, 87-94.
17. Alseth,I., Osman,F., Korvald,H., Tsaneva,I., Whitby,M.C., Seeberg,E. and Bjoras,M. (2005) Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe. Nucleic Acids Res., 33, 1123-1131.
18. Bahler,J., Wu,J., Longtine,M.S., Shah,N.G., McKenzie,A.,III, Steever,A.B., Wach,A., Philippsen,P. and Pringle,J.R. (1998) Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast, 14, 943-951.
19. Moreno,S., Klar,A. and Nurse,P. (1991) Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol., 194, 795-823.
20. 6-Alkylguanine-DNA alkyltransferase assay. Methods Mol. Biol., 152, 49-61.
21. 6-modified purines. Nucleic Acids Symp. Ser., 49, 23-24.
22. Duncan,T., Trewick,S.C., Koivisto,P., Bates,P.A., Lindahl,T. and Sedgwick,B. (2002) Reversal of DNA alkylation damage by two human dioxygenases. Proc. Natl Acad. Sci. USA, 99, 16660-16665.
23. 6-methylguanine DNA methyltransferase (MGMT). Nucleic Acids Res., 34, 1884-1891.
24. Volker,M., Mone,M.J., Karmakar,P., van Hoffen,A., Schul,W., Vermeulen,W., Hoeijmakers,J.H., van Driel,R., van Zeeland,A.A. and Mullenders,L.H. (2001) Sequential assembly of the nucleotide excision repair factors in vivo. Mol. Cell, 8, 213-224.
25. Friedberg,E.C. (2005) Suffering in silence: The tolerance of DNA damage. Nature Rev. Mol. Cell Biol., 6, 943-953.
26. 6-alkylguanine in mammalian cells. J. Cell Sci. Suppl., 6, 147-160.
27. 6-alkylguanines in the nuclear DNA of human lymphocytes and leukaemic cells: Analysis at the single-cell level. Br. J. Cancer, 69, 698-705.
28. Bol,S.A., van Steeg,H., van Oostrom,C.T., Tates,A.D., Vrieling,H., de Groot,A.J., Mullenders,L.H., van Zeeland,A.A. and Jansen,J.G. (1999) Nucleotide excision repair modulates the cytotoxic and mutagenic effects of N-n-butyl-N-nitrosourea in cultured mammalian cells as well as in mouse splenocytes in vivo. Mutagenesis, 14, 317-322.