Hyperthyroidism is characterized by both increased sympathetic and decreased vagal modulation of heart rate: Evidence from spectral analysis of heart rate variability

Clinical Endocrinology

Volumn 64, Issue 6, 2006, Pages 611-616

  Chen, Jin Long ^a,b   Chiu, Hung Wen ^c   Tseng, Yin Jiun ^b   Chu, Woei Chyn ^b  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHYROID AGENT; THYROID HORMONE;

ADRENERGIC SYSTEM; ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; ELECTROCARDIOGRAPHY MONITORING; FEMALE; GRAVES DISEASE; HEART RATE VARIABILITY; HUMAN; HYPERTHYROIDISM; MALE; MATHEMATICAL COMPUTING; PRIORITY JOURNAL; SINUS NODE; SPECTROSCOPY; VAGUS NERVE STIMULATION;

ADULT; ANTITHYROID AGENTS; AUTONOMIC NERVOUS SYSTEM; CASE-CONTROL STUDIES; ELECTROCARDIOGRAPHY, AMBULATORY; FEMALE; GRAVES DISEASE; HEART RATE; HUMANS; HYPERTHYROIDISM; MALE; PARASYMPATHETIC NERVOUS SYSTEM; SIGNAL PROCESSING, COMPUTER-ASSISTED; STATISTICS, NONPARAMETRIC; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 33646824177     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2006.02514.x     Document Type: Article

References (36)

1. Levey, G.S. Klein, I. 1990 Catecholamine-thyroid hormone interactions and the cardiovascular manifestations of hyperthyroidism. American Journal of Medicine, 88, 642 646.
2. Fazio, S., Palmieri, E.A., Lombardi, G. Biondi, B. 2004 Effects of thyroid hormone on the cardiovascular system. Recent Progress in Hormone Research, 59, 31 50.
3. Christensen, N.J. 1973 Plasma noradrenaline and adrenaline in patients with thyrotoxicosis and myxoedema. Clinical Science and Molecular Medicine, 45, 163 171.
4. Coulombe, P., Dussault, J.H. Walker, P. 1976 Plasma catecholamine concentrations in hyperthyroidism and hypothyroidism. Metabolism: Clinical and Experimental, 25, 973 979.
5. Coulombe, P., Dussault, J.H., Letarte, J. Simmard, S.J. 1976 Catecholamines metabolism in thyroid diseases. I. Epinephrine secretion rate in hyperthyroidism and hypothyroidism. Journal of Clinical Endocrinology and Metabolism, 42, 125 131.
6. Coulombe, P., Dussault, J.H. Walker, P. 1977 Catecholamine metabolism in thyroid disease. II. Norepinephrine secretion rate in hyperthyroidism and hypothyroidism. Journal of Clinical Endocrinology and Metabolism, 44, 1185 1189.
7. Moghetti, P., Castello, R., Tosi, F., Zenti, M.G., Magnani, C., Bolner, A., Perobelli, L. Muggeo, M. 1994 Glucose counterregulatory response to acute hypoglycemia in hyperthyroid human subjects. Journal of Clinical Endocrinology and Metabolism, 78, 169 173.
8. Bilezikian, J.P. Loeb, J.N. 1983 The influence of hyperthyroidism and hypothyroidism on α- and β-adrenergic receptor systems and adrenergic responsiveness. Endocrine Reviews, 4, 378 388.
9. Liggett, S.B., Shah, S.D. Cryer, P.E. 1989 Increased fat and skeletal muscle β-adrenergic receptors but unaltered metabolic and hemodynamic sensitivity to epinephrine in vivo in experimental human thyrotoxicosis. Journal of Clinical Investigation, 83, 803 809.
10. Metz, L.D., Seidler, F.J., McCook, E.C. Slotkin, T.A. 1996 Cardiac α-adrenergic receptor expression is regulated by thyroid hormone during a critical developmental period. Journal of Molecular and Cellular Cardiology, 28, 1033 1044.
11. Levine, M.A., Feldman, A.M., Robishaw, J.D., Ladenson, P.W., Ahn, T.G., Moroney, J.F. Smallwood, P.M. 1990 Influence of thyroid hormone status on expression of genes encoding G protein subunits in the rat heart. Journal of Biological Chemistry, 265, 3553 3560.
12. Heimbach, D.M. Crout, J.R. 1972 Effect of atropine on the tachycardia of hyperthyroidism. Archives of Internal Medicine, 129, 430 432.
13. Maciel, B.C., Gallo, L. Jr., Marin Neto, J.A., Maciel, L.M.Z., Alves, M.L.D., Paccola, G.M.F. Iazigi, N. 1987 The role of the autonomic nervous system in the resting tachycardia of human hyperthyroidism. Clinical Science, 72, 239 244.
14. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. 1996 Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Circulation, 93, 1043 1065.
15. Akselrod, S., Gordon, D., Ubel, F.A., Shannon, D.C., Barger, A.C. Cohen, R.J. 1981 Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science, 213, 220 222.
16. Pagani, M., Lombardi, F., Guzzetti, S., Rimoldi, O., Furlan, R., Pizzinelli, P., Sandrone, G., Malfatto, G., Dell'Orto, S., Piccaluga, E., Turiel, M., Baselli, G., Cerutti, S. Malliani, A. 1986 Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circulation Research, 59, 178 193.
17. Pomeranz, B., Macaulay, R.J.B., Caudill, M.A., Kutz, I., Adam, D., Gordon, D., Kilborn, K.M., Barger, A.C., Shannon, D.C., Cohen, R.J. Benson, H. 1985 Assessment of autonomic function in humans by heart rate spectral analysis. American Journal of Physiology. Heart and Circulatory Physiology, 248, H151 H153.
18. Malliani, A., Pagani, M., Lombardi, F. Cerutti, S. 1991 Cardiovascular neural regulation explored in the frequency domain. Circulation, 84, 482 492.
19. Appel, M.L., Berger, R.D., Saul, J.P., Smith, J.M. Cohen, R.J. 1989 Beat to beat variability in cardiovascular variables: noise or music? Journal of the American College of Cardiology, 14, 1139 1148.
20. Montano, N., Ruscone, T.G., Porta, A., Lombardi, F., Pagani, M. Malliani, A. 1994 Power spectrum analysis of heart rate variability to assess the changes in sympathovagal balance during graded orthostatic tilt. Circulation, 90, 1826 1831.
21. Fleisher, L.A., Frank, S.M., Sessler, D.I., Cheng, C., Matsukawa, T. Vannier, C.A. 1996 Thermoregulation and heart rate variability. Clinical Science, 90, 97 103.
22. Bonaduce, D., Marciano, F., Petretta, M., Migaux, M.L., Morgano, G., Bianchi, V., Salemme, L., Valva, G. Condorelli, M. 1994 Effects of converting enzyme inhibition on heart period variability in patients with acute myocardial infarction. Circulation, 90, 108 113.
23. Cacciatori, V., Bellavere, F., Pezzarossa, A., Dellera, A., Gemma, M.L., Thomaseth, K., Castello, R., Moghetti, P. Muggeo, M. 1996 Power spectral analysis of heart rate in hyperthyroidism. Journal of Clinical Endocrinology and Metabolism, 81, 2828 2835.
24. Inukai, T., Takanashi, K., Kobayashi, H., Fujiwara, Y., Tayama, K., Aso, Y. Takemura, Y. 1998 Power spectral analysis of variations in heart rate in patients with hyperthyroidism or hypothyroidism. Hormone and Metabolic Research, 30, 531 535.
25. Girard, A., Hugues, F.-C., Le Jeunne, C. Elghozi, J.-L. 1998 Short-term variability of blood pressure and heart rate in hyperthyroidism. Clinical Autonomic Research, 8, 181 186.
26. Burggraaf, J., Tulen, J.H.M., Lalezari, S., Schoemaker, R.C., De Meyer, P.H.E.M., Meinders, A.E., Cohen, A.F. Pijl, H. 2001 Sympathovagal imbalance in hyperthyroidism. American Journal of Physiology. Endocrinology and Metabolism, 281, E190 E195.
27. Pitzalis, M.V., Mastropasqua, F., Massari, F., Ciampolillo, A., Passantino, A., Ognissanti, M., Mannarini, A., Zanna, D., Giorgino, R. Rizzon, P. 1998 Assessment of cardiac vagal activity in patients with hyperthyroidism. International Journal of Cardiology, 64, 145 151.
28. Maciel, B.C., Gallo, L. Jr., Marin Neto, J.A., Maciel, L.M.Z. Martins, L.E.B. 1988 Autonomic control of heart rate during dynamic exercise in human hyperthyroidism. Clinical Science, 75, 209 215.
29. Kollai, B. Kollai, M. 1988 Reduced cardiac vagal excitability in hyperthyroidism. Brain Research Bulletin, 20, 785 790.
30. Inukai, T., Kobayashi, I., Kobayashi, T., Ishii, A., Yamaguchi, T., Yamaguchi, Y., Iwashita, A., Shimomura, Y. Kobayashi, S. 1990 Parasympathetic nervous system in patients with Graves' disease determined by R-R interval variations on electrocardiogram. Experimental and Clinical Endocrinology, 96, 289 295.
31. Petretta, M., Bonaduce, D., Spinelli, L., Vicario, M.L.E., Nuzzo, V., Marciano, F., Camuso, P., De Sanctis, V. Lupoli, G. 2001 Cardiovascular haemodynamics and cardiac autonomic control in patients with subclinical and overt hyperthyroidism. European Journal of Endocrinology, 145, 691 696.
32. Osman, F., Franklyn, J.A., Daykin, J., Chowdhary, S., Holder, R.L., Sheppard, M.C. Gammage, M.D. 2004 Heart rate variability and turbulence in hyperthyroidism before, during, and after treatment. American Journal of Cardiology, 94, 465 469.
33. Bigger, J.T. Jr., Fleiss, J.L., Steinman, R.C., Rolnitzky, L.M., Kleiger, R.E. Rottman, J.N. 1992 Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation, 85, 164 171.
34. Bigger, J.T. Jr., Fleiss, J.L., Rolnitzky, L.M. Steinman, R.C. 1993 Frequency domain measures of heart period variability to assess risk late after myocardial infarction. Journal of the American College of Cardiology, 21, 729 736.
35. Franklyn, J.A., Maisonneuve, P., Sheppard, M.C., Betteridge, J. Boyle, P. 1998 Mortality after the treatment of hyperthyroidism with radioactive iodine. New England Journal of Medicine, 338, 712 718.
36. Franklyn, J.A., Sheppard, M.C. Maisonneuve, P. 2005 Thyroid function and mortality in patients treated for hyperthyroidism. Journal of the American Medical Association, 294, 71 80.