Integrity and stability studies of precipitated rhBMP-2 microparticles with a focus on ATR-FTIR measurements

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 63, Issue 3, 2006, Pages 241-248

  Schwartz, Daniel ^a   Sofia, Susan ^b   Friess, Wolfgang ^c  

^a MERCK KGAA   (Germany)

^b PFIZER INC   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

ATR FTIR; Microparticles; Precipitation; Protein integrity; Protein stability; Recombinant human Bone Morphogenetic Protein 2

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; GEL PERMEATION CHROMATOGRAPHY; INFRARED SPECTROSCOPY; ISOMERIZATION; MELTING POINT; PARTICLE SIZE; PEPTIDE MAPPING; PRECIPITATION; PROTEIN AGGREGATION; PROTEIN STRUCTURE; TEMPERATURE DEPENDENCE;

BONE MORPHOGENETIC PROTEINS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG STABILITY; HUMANS; PRECIPITATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE; TRANSFORMING GROWTH FACTOR BETA;

EID: 33646824162     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.12.011     Document Type: Article

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