Mixed small cell carcinomas of the uterine cervix: prognostic impact of focal neuroendocrine differentiation but not of Ki-67 labeling index

Annals of Diagnostic Pathology

Volumn 10, Issue 3, 2006, Pages 140-143

  Horn, Lars Christian ^a   Hentschel, Bettina ^a   Bilek, Karl ^a   Richter, Christine E ^a   Einenkel, Jens ^a   Leo, Cornelia ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Cervix uteri; Ki 67; MIB 1; Prognosis; Small cell carcinoma

Indexed keywords

CD56 ANTIGEN; CD99 ANTIGEN; CHROMOGRANIN; ENOLASE; KI 67 ANTIGEN;

ADULT; ARTICLE; CANCER SURVIVAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LABELING INDEX; NEUROSECRETORY CELL; PRIORITY JOURNAL; PROGNOSIS; SMALL CELL CARCINOMA; STAINING; UTERINE CERVIX;

ADULT; CARCINOMA, NEUROENDOCRINE; CARCINOMA, SMALL CELL; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MIDDLE AGED; PROGNOSIS; SILVER NITRATE; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS;

EID: 33646812936     PISSN: 10929134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anndiagpath.2005.07.019     Document Type: Article

References (19)

1. Abeler V.M., Holm R., Nesland J.M., and Kjörstad K.E. Small cell carcinoma of the cervix. A clinicopathologic study of 26 patients. Cancer 73 (1994) 672-677
2. Horn L.C., Fischer U., and Bilek K. Neuroendocrine carcinomas of the cervix uteri. Zentralbl Gynakol 118 (1996) 679-683
3. Stoler M.H., Mills S.E., Gersell D.J., and Walker A.N. Small-cell neuroendocrine carcinoma of the cervix. A human papillomavirus type 18-associated cancer. Am J Surg Pathol 15 (1991) 28-32
4. Albores-Saavedra J., Ashfaq R., and Henson D.E. Carcinoid and small cell carcinomas of the uterine cervix. Lab Invest 74 (1996) 87-91
5. Masumoto N., Fujii T., Ushikawa M., Saito M., Iwata T., Fukuchi T., et al. p16 overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix. Hum Pathol 34 (2003) 778-783
6. Pillai M.R., Jayaprakash P.G., and Nair M.K. Tumour-proliferative fraction and growth factor expression as markers of tumour response to radiotherapy in cancer of the uterine cervix. J Cancer Res Clin Oncol 124 (1998) 456-466
7. Van de Putte G., Kristensen G.B., Lie A.K., Baekelandt M., and Holm R. Cyclins and proliferation markers in early squamous cervical carcinoma. Gynecol Oncol 92 (2004) 40-46
8. Avall-Lundqvist E.H., Silfversward C., Aspenblad U., Nilsson B.R., and Auer G.U. The impact of tumour angiogenesis, p53 overexpression and proliferative activity (MIB-1) on survival in squamous cervical carcinoma. Eur J Cancer 33 (1997) 1799-1804
9. Horn L.C., and Bilek K. The usefulness of tumor registry in cervical cancer. Zentralbl Gynakol 123 (2001) 311-314
10. Horn L.C., Fischer U., and Bilek K. Pathologic-anatomic description and basic morphological information for management of dysplasias and carcinomas of the cervix uteri. Zentralbl Gynakol 123 (2001) 255-265
11. Albores-Saaverdra J., Lazarra O., Poucell S., and Rodriguez-Martinez H.A. Primary carcinoid of the uterine cervix. Patologia 10 (1972) 185-193
12. Conner M.G., Richter H., Moran C., Hameed A., and Albores-Saaverdra J. Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. Ann Diagn Pathol 6 (2002) 345-348
13. Straughn Jr. J.M., Richter H.E., Conner M.G., Meleth S., and Barnes M.N. Predictors of outcome in small cell carcinoma of the cervix-a case series. Gynecol Oncol 83 (2001) 216-220
14. Viswanathan A.N., Deavers M.T., Jhingran A., Ramirez P.T., Levenback C., and Eifel P.J. Small cell neuroendocrine carcinoma of the cervix: outcome and pattern of recurrence. Gynecol Oncol 93 (2004) 27-33
15. Chavez-Blanco A., Taja-Chayeb L., Cetina L., Chona-Vilchis G., Trjo-Becerril C., Perez-Cardenas E., et al. Neuroendocrine marker expression in cervical mixed carcinomas of non-small cell type. Int J Gynecol Pathol 21 (2002) 368-374
16. Boruta II D.M., Schorge J.O., Duska L.A., Crum C.P., Castrillon D.H., and Sheets E.E. Multimodality therapy in early-stage neuroendocrine carcinoma of the uterine cervix. Gynecol Oncol 81 (2001) 82-87
17. Kusayanagi S., Konishi K., Maysaka N., Sasaki K., Kurahashi T., Kaneko K., et al. Primary small cell carcinoma of the stomach. J Gastroeneterol Hepatol 18 (2003) 743-747
18. Okudela K., Ito T., Kameda Y., Nakamura N., and Kitamura H. Immunohistochemical analysis for cell proliferation-related protein expression in small cell carcinoma of the esophagus; a comparative study with small cell carcinoma of the lung and squamous cell carcinoma of the esophagus. Histol Histopathol 14 (1999) 479-485
19. Graflund M., Sorbe B., and Karlsson M. MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas: correlation with clinical outcome. Int J Oncol 20 (2002) 1041-1047