Membranous Glomerulopathy With Spherules: An Uncommon Variant With Obscure Pathogenesis

American Journal of Kidney Diseases

Volumn 47, Issue 6, 2006, Pages 983-992

  Kowalewska, Jolanta ^a,b,c,d   Smith, Kelly D ^a,b,c,d   Hudkins, Kelly L ^a,b,c,d   Chang, Anthony ^a,b,c,d   Fogo, Agnes B ^a,b,c,d   Houghton, Donald ^a,b,c,d   Leslie, Deena ^a,b,c,d   Aitchison, John ^a,b,c,d   Nicosia, Roberto F ^a,b,c,d   Alpers, Charles E ^a,b,c,d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Institute for System Biology   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Membranous glomerulopathy; nuclear pore; spherules

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTINUCLEAR ANTIBODY; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MONOCLONAL ANTIBODY; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID;

ADULT; AGED; ALLOGRAFT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS CAPILLARY; HEMODIALYSIS; HUMAN; HUMAN TISSUE; IMMUNE COMPLEX DEPOSITION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; KIDNEY BIOPSY; MALE; MEMBRANOUS GLOMERULONEPHRITIS; NEPHROTIC SYNDROME; NUCLEAR PORE; RECURRENT DISEASE; ULTRASTRUCTURE;

ADULT; AGED; ANTIBODIES, ANTINUCLEAR; ANTIGEN-ANTIBODY COMPLEX; EPITHELIUM; FEMALE; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; NUCLEAR PORE; ORGANELLES; TRANSPLANTATION, HOMOLOGOUS;

EID: 33646799838     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2006.03.004     Document Type: Article

References (34)

1. Gamble C.N., and Reardan J.B. Immunopathogenesis of syphilitic glomerulonephritis. Elution of antitreponemal antibody from glomerular immune-complex deposits. N Engl J Med 292 (1975) 449-454
2. Jordan S.C., Buckingham B., Sakai R., and Olson D. Studies of immune-complex glomerulonephritis mediated by human thyroglobulin. N Engl J Med 304 (1981) 1212-1215
3. Lai K.N., Li P.K., Lui S.F., et al. Membranous nephropathy related to hepatitis B virus in adults. N Engl J Med 324 (1991) 1457-1463
4. Nagashima R., Maeda K., Yuda F., Kudo K., Saitoh M., and Takahashi T. Helicobacter pylori antigen in the glomeruli of patients with membranous nephropathy. Virchows Arch 431 (1997) 235-239
5. Takekoshi Y., Tanaka M., Miyakawa Y., Yoshizawa H., Takahashi K., and Mayumi M. Free "small" and IgG-associated "large" hepatitis B e antigen in the serum and glomerular capillary walls of two patients with membranous glomerulonephritis. N Engl J Med 300 (1979) 814-819
6. van Bruggen M.C., Kramers C., Walgreen B., et al. Nucleosomes and histones are present in glomerular deposits in human lupus nephritis. Nephrol Dial Transplant 12 (1997) 57-66
7. Winfield J.B., Faiferman I., and Koffler D. Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis. J Clin Invest 59 (1977) 90-96
8. Ronco P.M. Paraneoplastic glomerulopathies. New insights into an old entity. Kidney Int 56 (1999) 355-377
9. Markowitz G.S. Membranous glomerulopathy. Emphasis on secondary forms and disease variants. Adv Anat Pathol 8 (2001) 119-125
10. Venkataseshan V.S., Lieberman K., Kim D.U., et al. Hepatitis-B-associated glomerulonephritis. Pathology, pathogenesis, and clinical course. Medicine (Baltimore) 69 (1990) 200-216
11. Debiec H., Nauta J., Coulet F., et al. Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies. Lancet 364 (2004) 1252-1259
12. Debiec H., Guigonis V., Mougenot B., et al. Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med 346 (2002) 2053-2060
13. Dales S., and Wallace A.C. Nuclear pore complexes deposited in the glomerular basement membrane are associated with autoantibodies in a case of membranous nephritis. J Immunol 134 (1985) 1588-1593
14. Unwin P.N., and Milligan R.A. A large particle associated with the perimeter of the nuclear pore complex. J Cell Biol 93 (1982) 63-75
15. Barry M., and Rennke H.G. "Nuclear pore" glomerulopathy. A clinicopathological study. Mod Pathol 17 (2004) 284A (abstr)
16. Burkholder P.M., Hyman L.R., and Barber T.A. Extracellular clusters of spherical microparticles in glomeruli in human renal glomerular diseases. Lab Invest 28 (1973) 415-425
17. Alpers C.E., Marchioro T.L., and Johnson R.J. Monoclonal immunoglobulin deposition disease in a renal allograft. Probable recurrent disease in a patient without myeloma. Am J Kidney Dis 13 (1989) 418-423
18. Davis L.I., and Blobel G. Identification and characterization of a nuclear pore complex protein. Cell 45 (1986) 699-709
19. Ou Y., Enarson P., Rattner J.B., Barr S.G., and Fritzler M.J. The nuclear pore complex protein Tpr is a common autoantigen in sera that demonstrate nuclear envelope staining by indirect immunofluorescence. Clin Exp Immunol 136 (2004) 379-387
20. Hudkins K.L., Giachelli C.M., Eitner F., Couser W.G., Johnson R.J., and Alpers C.E. Osteopontin expression in human crescentic glomerulonephritis. Kidney Int 57 (2000) 105-116
21. Turner A.J., Isaac R.E., and Coates D. The neprilysin (NEP) family of zinc metalloendopeptidases. Genomics and function. Bioessays 23 (2001) 261-269
22. Falk R.J., Scheinman J., Phillips G., Orringer E., Johnson A., and Jennette J.C. Prevalence and pathologic features of sickle cell nephropathy and response to inhibition of angiotensin-converting enzyme. N Engl J Med 326 (1992) 910-915
23. Metzgar R.S., Borowitz M.J., Jones N.H., and Dowell B.L. Distribution of common acute lymphoblastic leukemia antigen in nonhematopoietic tissues. J Exp Med 154 (1981) 1249-1254
24. Blobel G., and Potter V.R. Nuclei from rat liver. Isolation method that combines purity with high yield. Science 154 (1966) 1662-1665
25. Cronshaw J.M., Krutchinsky A.N., Zhang W., Chait B.T., and Matunis M.J. Proteomic analysis of the mammalian nuclear pore complex. J Cell Biol 158 (2002) 915-927
26. Matunis M.J., Coutavas E., and Blobel G. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol 135 (1996) 1457-1470
27. Hoeijmakers J.H., Schel J.H., and Wanka F. Structure of the nuclear pore complex in mammalian cells. Two annular components. Exp Cell Res 87 (1974) 195-206
28. Stoffler D., Feja B., Fahrenkrog B., Walz J., Typke D., and Aebi U. Cryo-electron tomography provides novel insights into nuclear pore architecture. Implications for nucleocytoplasmic transport. J Mol Biol 328 (2003) 119-130
29. Fahrenkrog B., Koser J., and Aebi U. The nuclear pore complex. A jack of all trades?. Trends Biochem Sci 29 (2004) 175-182
30. Couser W.G., and Alpers C.E. Membranous nephropathy. In: Neilson E.G., and Couser W.G. (Eds). Immunologic Renal Diseases. ed 2 (2001), Lippincott-Raven, Philadelphia, PA 1029-1035
31. Mandal A.K., Mask D.R., Nordquist J., Chrysant K.S., and Lindeman R.D. Membranous glomerulonephritis. Virus-like inclusions in glomerular basement membrane. Ann Intern Med 80 (1974) 554-555
32. Akhtar M., Bunuan H., and Al-Mohaya S. Renal lesion in a 50-year-old Saudi man. Ultrastruct Pathol 4 (1983) 107-113
33. Watson M.L. Further observations on the nuclear envelope of the animal cell. J Biophys Biochem Cytol 6 (1959) 147-156
34. Rout M.P., and Aitchison J.D. The nuclear pore complex as a transport machine. J Biol Chem 276 (2001) 16593-16596