Solvent isotope effects and the question of quantum tunneling in hydrolytic enzyme action

Journal of Nuclear Science and Technology

Volumn 43, Issue 4, 2006, Pages 455-460

  Garoutte, Michael P ^a   Bibbs, Jeffrey A ^b   Schowen, Richard L ^c  

^a MISSOURI SOUTHERN STATE UNIVERSITY   (United States)

^b Pharmatek Laboratories Inc   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

Catalysis; Deuterium oxide; Enzyme; General base catalysis; Hydrolysis; Mechanism; Quantum tunneling; Solvent isotope effect; Trypsin

Indexed keywords

GENERAL-BASE CATALYSIS; QUANTUM TUNNELING; SOLVENT ISOTOPE EFFECT; SOLVENT ISOTOPE EFFECTS; TRYPSIN;

CATALYSTS; DEUTERIUM COMPOUNDS; ENZYME KINETICS; ENZYMES; HYDROLYSIS; QUANTUM THEORY; SOLVENTS;

RADIOISOTOPES;

EID: 33646795635     PISSN: 00223131     EISSN: 00223131     Source Type: Journal    
DOI: 10.3327/jnst.43.455     Document Type: Article

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