Designing Spiegelmers to antagonise ghrelin

Gut

Volumn 55, Issue 6, 2006, Pages 754-755

  Hornby, P J ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; APTAMER; CALCIUM; GHRELIN; MACROGOL; NOX B 11; NOX B11; RIBOSE; SPIEGELMER; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

CALCIUM TRANSPORT; CLINICAL TRIAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG INHIBITION; DRUG SYNTHESIS; ENTERITIS; GENE EXPRESSION; HUMAN; IC 50; NONHUMAN; NOTE; OBESITY; PRADER WILLI SYNDROME; PRIORITY JOURNAL; PSORIASIS;

EATING; HUMANS; OLIGONUCLEOTIDES; PEPTIDE HORMONES; STEREOISOMERISM;

EID: 33646783635     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2005.076067     Document Type: Note

References (10)

1. Kobelt P, Helmling S, Stengel A, et al. Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats. Gut 2006;55:788-92.
2. Tanaka-Shintani M, Watanabe M. Distribution of ghrelin-immunoreactive cells in human gastric mucosa: comparison with that of parietal cells. J Gastroenterol 2005;40:345-9.
3. Rose K, Bougueleret L, Baussant T, et al. Industrial-scale proteomics: from liters of plasma to chemically synthesized proteins. Proteomics 2004;4:2125-50.
4. Nakai Y, Hosoda H, Nin K, et al. Plasma levels of active form of ghrelin during oral glucose tolerance test in patients with anorexia nervosa. Eur J Endocrinol 2003;149:R1-3.
5. Helmling S, Maasch C, Eulberg D, et al. Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer. Proc Natl Acad Sci U S A 2004;101:13174-9.
6. Shanahan WR Jr. ISIS 2302, an antisense inhibitor of intercellular adhesion molecule 1. Expert Opin Investig Drugs 1999;8:1417-29.
7. Schumacher TN, Mayr LM, Minor DL Jr, et al. Identification of D-peptide ligands through mirror-image phage display. Science 1990;271:1854-7.
8. Klussmann S, Nolte A, Bald R, et al. Mirror-image RNA that binds D-adenosine. Nat Biotechnol 1996;14:1112-15.
9. Mondal MS, Date Y, Yamaguchi H, et al. Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus. Regul Pept 2005;126:55-9.
10. Wang L, Saint-Pierre DH, Tache Y. Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus. Neurosci Lett 2002;325:47-51.