Impact of hypothermia on the response to neuromuscular blocking drugs

Anesthesiology

Volumn 104, Issue 5, 2006, Pages 1070-1080

  Heier, Tom ^a   Caldwell, James E ^b  

^a AKER UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCURONIUM; ATRACURIUM; DECAMETHONIUM; NEOSTIGMINE; NEUROMUSCULAR BLOCKING AGENT; PANCURONIUM; ROCURONIUM; SUXAMETHONIUM; TUBOCURARINE CHLORIDE; VECURONIUM;

ANESTHESIA; BILIARY EXCRETION; BODY TEMPERATURE; COOLING; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG EFFECT; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; ELECTROMYOGRAPHY; HUMAN; HYPOTHERMIA; INTRAOPERATIVE PERIOD; MONITORING; MUSCLE STRENGTH; MUSCLE TONE; MUSCLE TWITCH; NEUROMUSCULAR BLOCKING; NEUROMUSCULAR TRANSMISSION; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; REVIEW; URINARY EXCRETION; VASOCONSTRICTION;

ANIMALS; BODY TEMPERATURE; COLD; ELECTROMYOGRAPHY; HUMANS; HYPOTHERMIA; MUSCLE CONTRACTION; NEUROMUSCULAR BLOCKING AGENTS; SYNAPTIC TRANSMISSION;

EID: 33646783612     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200605000-00025     Document Type: Review

References (95)

1. Flacke W: Temperature regulation and anesthesia. Int Anesthesiol Clin 1963; 2:43-54
2. Sessler D: Temperature monitoring, Anesthesia, 6th edition. Edited by Miller R. New York, Churchill-Livingstone, 2005, pp 1571-98
3. Viby-Mogensen J, Chraemmer-Joergensen B, Oerding H: Residual curarization in the recovery room. ANESTHESIOLOGY 1979; 50:539-43
4. Heier T, Steen PA: Residual curarization after reversal with neostigmine. Tidsskr Nor Laegeforen 1986; 106:1098-100
5. Bevan DR, Donati F, Kopman AF: Reversal of neuromuscular blockade. ANESTHESIOLOGY 1992; 77:785-805
6. Fawcett WJ, Dash A, Francis GA, Liban JB, Cashman JN: Recovery from neuromuscular blockade: Residual curarization following atracurium or vecuronium by bolus dosing or infusions. Acta Anaesthesiol Scand 1995; 39:288-93
7. Naguib M, Lien CA: Pharmacology of muscle relaxants and their antagonists, Anesthesia, 6th edition. Edited by Miller RD. New York, Churchill-Livingstone, 2005, pp 481-572
8. Hill AV: The influence of temperature on the tension developed in an isometric twitch. Proc R Soc Lond [B101] 1951; 138:349-54
9. MacPherson L, Wilkie DR: The duration of the active state in a muscle twitch. J Physiol 1954; 124:292
10. Letley E: The effect of temperature on the direct muscle twitch response and the action of drugs on the isolated denervated rat diaphragm. Br J Pharmacol 1960; 15:345-50
11. Friess SL, Weissberger A: Investigation of Rates and Mechanisms of Reactions, 1st edition. New York, Interscience, 1953
12. Rutgers A: Physical Chemistry, 1st edition. New York, Interscience, 1954
13. Bowman W: Effect of temperature, Pharmacology of the Neuromuscular Function. Edited by Bowman W. Baltimore, University Park Press, 1981, pp 108-9
14. Buchthal F, Rosenfalck A: Evoked action potentials and conduction velocity in human sensory nerves. Brain Res 1966; 3:54-5
15. Harris JB, Leach GD: The effect of temperature on end-plate depolarization of the rat diaphragm produced by suxamethonium and acetyl choline. J Pharm Pharmacol 1968; 20:194-8
16. Hubbard JI, Jones SF, Landau EM: The effect of temperature change upon transmitter release, facilitation and post-tetanic potentiation. J Physiol 1971; 216:591-609
17. Ward D, Crowley WJ, Johns TR: Effect of temperature at the neuromuscular transmission. Am J Physiol 1972; 222:216-9
18. Zink J, Bose D: Cold potentiation of neuromuscular transmission in the avian biventer cervicis muscle. Eur J Pharmacol 1974; 28:149-56
19. Horrow JC, Bartkowski RR: Pancuronium, unlike other nondepolarizing relaxants, retains potency at hypothermia. ANESTHESIOLOGY 1983; 58:357-61
20. Carpenter DO: Temperature effects on pacemaker generation, membrane potential, and critical firing threshold in aplysia neurons. J Gen Physiol 1967; 50:1469-84
21. Hodgkin AL, Katz B: The effect of temperature on the electrical activity of the giant axon of the squid. J Physiol 1949; 109:240-9
22. Boyd A, Martin AR: The end-plate potential in mammalian muscle. J Physiol (London) 1956; 132:74-92
23. Kasai M, Changeux JP: In vitro excitation of purified membrane fragments by cholinergic agonists. J Membrane Biol 1971; 6:1-23
24. Buller AJ, Ranatunga KW, Smith J: Influence of temperature on the isometric myograms of cross innervated mammalian fast twitch and slow twitch skeletal muscles. Nature 1968; 218:877-8
25. Bigland B, Goetzee B, MacLagan J, Zaimis E: The effect of lowered muscle temperature on the action of neuromuscular blocking drugs. J Physiol 1958; 141:425-34
26. Miller RD, Roderick LL: Pancuronium-induced neuromuscular blockade, and its antagonism by neostigmine, at 29, 37, and 41°C ANESTHESIOLOGY 1977; 46:333-5
27. Miller RD, Agoston S, van der Pol F, Booij LHDJ, Crul JF, Ham J: Hypothermia and the pharmacokinetics and pharmacodynamics of pancuronium in the cat. J Pharmacol Exp Ther 1978; 207:532-8
28. Engbæk J, Skovgaard LT, Friis B, Kann T, Viby-Mogensen J: Monitoring of the neuromuscular transmission by electromyography (I): Stability and temperature dependence of evoked EMG response compared to mechanical twitch recordings in the cat. Acta Anaesthesiol Scand 1992; 36:495-504
29. Thornton RJ, Blakeney C, Feldman SA: The effect of hypothermia on neuromuscular conduction. Br J Anaesth 1976; 48:264
30. Ricker K, Hertel G, Stodieck G: Increased voltage of the muscle action potential of normal subjects after local cooling. J Neurol 1979; 216:33-8
31. Bigland-Ritchie B, Thomas CK, Rice CL, Howarth JV, Woods JJ: Muscle temperature, contractile speed, and motoneuron firing rates during human voluntary contractions. J Appl Physiol 1992; 73:2457-61
32. Cannard TH, Zaimis E: The effect of lowered muscle temperature on the action of neuromuscular blocking drugs in man. J Physiol 1959; 149:112-9
33. Eriksson LI, Lenmarken C, Jensen E, Viby-Mogensen J: Twitch tension and train-of-four ratio during prolonged neuromuscular monitoring at different peripheral temperatures. Acta Anaesthesiol Scand 1991; 35:247-52
34. Buzello W, Pollmaecher T, Schluermann D, Urbanyi B: The influence of hypothermic cardiopulmonary bypass on neuromuscular transmission in the absence of muscle relaxants. ANESTHESIOLOGY 1986; 64:279-81
35. Ham J, Stanski DR, Newfield P, Miller RD: Pharmacokinetics and dynamics of d-tubocurarine during hypothermia in humans. ANESTHESIOLOGY 1981; 55:631-5
36. Heier T, Caldwell JE, Sessler DI, Kitts JB, Miller RD: The relationship between adductor pollicis twitch tension and core, skin, and muscle temperature during nitrous oxide-isoflurane anesthesia in humans. ANESTHESIOLOGY 1989; 71: 381-4
37. Heier T, Caldwell JE, Sessler DI, Miller RD: The effect of local surface and central cooling on adductor pollicis twitch tension during nitrous oxide-isoflurane and nitrous oxide-fentanyl anesthesia in humans. ANESTHESIOLOGY 1990; 72:807-11
38. Paton WDM, Waud DR: The margin of safety of neuromuscular transmission. J Physiol (London) 1967; 191:59-90
39. Brett RS, Dilger JP, Yland KF: Isoflurane causes "flickering" of the acetylcholine receptor channel: Observations using patch clamp. ANESTHESIOLOGY 1988; 6969:161-70
40. Eger RR, Eger E II: Effect of temperature and age on the solubility of enflurane, halothane, isoflurane and methoxyflurane in human blood. Anesth Analg 1985; 64:640-2
41. Lebowitz MH, Blitt CD, Waltz LF: Depression of twitch response to stimulation of the ulnar nerve during ethrane anesthesia in man. ANESTHESIOLOGY 1970; 33:52-7
42. Katz JA, Fragen RJ, Shanks CA, Dunn R, McNulty B, Rudd D: Dose-response relationships of doxacurium chloride in humans during anesthesia with nitrous oxide and fentanyl, enflurane, isoflurane, or halothane. ANESTHESIOLOGY 1989; 70:432-6
43. Holmes PEB, Jenden JD, Taylor DB: The analysis of the mode of action of curare on neuromuscular transmission: The effect of temperature changes. J Pharmacol Exp Ther 1951; 103:382-402
44. Farrell L, Dempsey MJ, Waud BE, Waud DR: Temperature and potency of d-tubocurarine and pancuronium in vitro. Anesth Analg 1981; 60:18-20
45. Yoneda I, Okamoto T, Aoki T, Fukushima K: The effect of temperature on the action of several neuromuscular blocking agents in vitro. Masui 1991;40:743-8
46. Aziz L, Ono K, Morita K, Hirakawa M: Effect of hypothermia on the in vitro potencies of neuromuscular blocking agents and on their antagonism by neostigmine. Br J Anaesth 1994; 73:662-6
47. Aziz L, Ohta Y, Yamada T, Morita K, Hirakawa M: The effect of isoflurane and temperature on the actions of muscle relaxants in rat in vitro. Anesth Analg 1995; 80:1181-6
48. Foldes FF: The significance of physiological calcium and magnesium for in vitro experiments on synaptic transmission. Life Sci 1981; 28:1585-90
49. Aziz L, Ono K, Ohta Y, Morita K, Hirakawa M: The effect of CO2-induced acid-base changes on the potencies of muscle relaxants and antagonism of neuromuscular block by neostigmine in rat in vitro. Anesth Analg 1994; 78: 322-7
50. Bartkowski RR, Horrow JC: Temperature and the potency of relaxants. Anesth Analg 1981; 60:455b-6b
51. Hubbard JI, Wilson DF: Neuromuscular transmission in a mammalian preparation in the absence of blocking drugs and the effect of d-tubocurarine. J Physiol 1973; 238:307-25
52. Ham J, Miller RD, Benet LZ, Matteo RS, Roderick LL: Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in the cat. ANESTHESIOLOGY 1978; 49:324-9
53. Miller RD, van Nyhuis LS, Eger E II: The effect of temperature on a tubocurarine neuromuscular blockade and its antagonism by neostigmine. J Pharmacol Exp Ther 1975; 195:237-41
54. England AJ, Wu X, Richards KM, Redai I, Feldman SA: The influence of cold on the recovery of three neuromuscular blocking agents in man. Anaesthesia 1996; 51:236-40
55. Young ML, Hanson CW III, Bloom MJ, Savino JS, Muravchick S: Localized hypothermia influences assessment of recovery from vecuronium neuromuscular blockade. Can J Anaesth 1994; 41:1172-7
56. Eriksson LI, Viby-Mogensen J, Lenmarken C: The effect of peripheral hypothermia on a vecuronium-induced neuromuscular block. Acta Anaesthesiol Scand 1991; 35:387-92
57. Thornberry EA, Mazumdar B: The effect of changes in arm temperature on neuromuscular monitoring in the presence of atracurium blockade. Anaesthesia 1988; 45:447-9
58. Heier T, Caldwell JE, Eriksson LI, Sessler DI, Miller RD: The effect of hypothermia on adductor pollicis twitch tension during continuous infusion of vecuronium in isoflurane-anesthetized humans. ANESTH ANALG 1994; 78:312-7
59. Heier T, Caldwell JE, Sessler DI, Miller RD: Mild intraoperative hypothermia increases duration of action and spontaneous recovery of vecuronium blockade during nitrous oxide-isoflurane anesthesia in humans. ANESTHESIOLOGY 1991; 74:815-9
60. Leslie K, Sessler DI, Bjorksten AR, Moayeri A: Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium. Anesth Analg 1995; 80:1007-14
61. Beaufort AM, Wierda JM, Belopavlovic M, Nederveen PJ, Kleef UW, Agoston S: The influence of hypothermia (surface cooling) on the time-course of action and on the pharmacokinetics of rocuronium in humans. Eur J Anaesthesiol Suppl 1995; 11:95-106
62. Park WY, Macnamara TE: Temperature change and neuromuscular blockade by d-tubocurarine or pancuronium in man. ANESTHESIOLOGY 1979; 50:161-3
63. Walker JS, Shanks CA, Brown KF: Altered d-tubocurarine disposition during cardiopulmonary bypass surgery. Clin Pharmacol Ther 1984; 35:668-94
64. d'Hollander AA, Duvaldestin P, Henzel D, Nevelsteen M, Bomblet JP: Variations in pancuronium requirement, plasma concentration, and urinary excretion induced by cardiopulmonary bypass with hypothermia. ANESTHESIOLOGY 1983; 58:505-9
65. Buzello W, Schluermann D, Pollmaecher T, Spillner G: Unequal effects of cardiopulmonary bypass-induced hypothermia on neuromuscular blockade from constant infusion of alcuronium, d-tubocurarine, pancuronium, and vecuronium. ANESTHESIOLOGY 1987; 66:842-6
66. Futter ME, Whalley DR, Wynands JE, Bevan DR: Pancuronium requirements during hypothermic cardiopulmonary bypass in man. Can Anaesth Soc J 1983; 30:S73-4
67. Flynn PJ, Hughes R, Walton B: Use of atracurium in cardiac surgery involving cardiopulmonary bypass with induced hypothermia. Br J Anaesth 1984; 56:967-72
68. Denny NM, Kneeshaw JD: Vecuronium and atracurium during hypothermic cardiopulmonary bypass. Anaesthesia 1986; 41:919-22
69. Duvaldestin P, Henzel D: Binding of d-tubocurarine, fazadinium, pancuronium and ORG NC45 to serum protein in normal man and in patients with cirrhosis. Br J Anaesth 1982; 54:513-6
70. Jones RM: Mivacurium in special patient groups. Acta Anaesthesiol Scand 1995; 106:47-54
71. Hemmerling TM, Donati F: Neuromuscular blockade at the larynx, the diaphragm and the corrugator supercilii muscle: A review. Can J Anaesth 2003; 50:779-94
72. Dhonneur G, Kirov K, Slavov V, Duvaldestin P: Effects of an intubating dose of succinylcholine and rocuronium on the larynx and diaphragm: An electromyographic study in humans. ANESTHESIOLOGY 1999; 90:951-5
73. Mills G, Khan Z, Moxham J, Desai J, Forsyth A, Ponte J: Effects of temperature on phrenic nerve and diaphragmatic function during cardiac surgery. Br J Anaesth 1997; 79:726-32
74. Laflin MJ: Interaction of pancuronium and corticosteroids. ANESTHESIOLOGY 1977; 47:471-2
75. Ornstein E, Matteo RS, Schwartz AE, Silverberg PA, Young WL, Diaz J: The effect of phenytoin on the magnitude and duration of neuromuscular block following atracurium and vecuronium. ANESTHESIOLOGY 1987; 67:191-6
76. Graham DH: Monitoring neuromuscular block may be unreliable in patients with upper-motor-neuron lesions. ANESTHESIOLOGY 1980; 52:74-5
77. Gencarelli PJ, Swen J, Koot HWJ, Miller RD: The effect of hypercarbia and hypocarbia on pancuronium and vecuronium neuromuscular blockades in anesthetized humans. ANESTHESIOLOGY 1983; 59:376-80
78. Caldwell JE, Heier T, Wright PMC, Lin S, McCarthy G, Szenohradszky J, Sharma ML, Hing JP, Schroeder M, Sessler DI: Temperature-dependent pharmacokinetics and pharmacodynamics of vecuronium. ANESTHESIOLOGY 2000; 92:84-93
79. Hull CJ: Pharmacodynamics of non-depolarizing neuromuscular blocking agents. Br J Anaesth 1982; 54:169-82
80. Holford NHG, Sheiner LB: Understanding the dose-effect relationship. Clin Pharmacokinet 1981; 6:429-54
81. Holford NHG, Sheiner LB: Kinetics of pharmacologic response. Pharmacol Ther 1982; 16:143-66
82. Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J: Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin Pharmacol Ther 1979; 25:358-71
83. Heier T, Caldwell JE, Sharma ML, Gruenke LD, Miller RD: Mild intraoperative hypothermia does not change the pharmacodynamics (concentration-effect relationship) of vecuronium in humans. Anesth Analg 1994; 78:973-7
84. Nakae Y, Fujita S, Namiki A: Isoproterenol enhances myofilament Ca(2+) sensitivity during hypothermia in isolated guinea pig beating hearts. Anesth Analg 2001; 93:846-52
85. Schioetz-Thorud H, Verburg E, Lunde P, Stroemme T, Sjaastad I, Sejersted O: Temperature dependent skeletal muscle dysfunction in rats with congestive heart failure. J Appl Physiol 2005; 99:1500-7
86. Stowe DF, Fujita S, An J, Paulsen RA, Varadarajan SG, Smart SC: Modulation of myocardial function and [Ca2+] sensitivity by moderate hypothermia in guinea pig isolated hearts. Am J Physiol 1999; 277:H2321-32
87. Heier T, Clough D, Wright PM, Sharma ML, Sessler DI, Caldwell JE: The influence of mild hypothermia on the pharmacokinetics and time course of action of neostigmine in anesthetized volunteers. ANESTHESIOLOGY 2002; 97:90-5
88. Heier T: The influence of temperature on the adductor pollicis twitch tension in the presence and absence of vecuronium, Muscle Relaxants: Physiologic and Pharmacologic Aspects. Edited by Fukushima K, Ochiai R. Tokyo, Springer, 1995, pp 249-58
89. Kaplan EB, Riordan DC: The thumb, Kaplan's Functional and Surgical Anatomy of the Hand. Edited by Spinner M. Philadelphia, JB Lippincott, 1984, pp 113-42
90. Sessler DI, Olofsson CI, Rubinstein EH, Beebe JJ: The thermoregulatory threshold in humans during halothane anesthesia. ANESTHESIOLOGY 1988; 68:835-42
91. Sessler DI, Olofsson CI, Rubinstein EH: The thermoregulatory threshold in humans during nitrous oxide-fentanyl anesthesia. ANESTHESIOLOGY 1988; 69:357-64
92. Sessler DI, Rubinstein EH, Eger E II: Core temperature changes during nitrous oxide-fentanyl and halothane anesthesia. ANESTHESIOLOGY 1987; 67:137-9
93. Epstein RM, Epstein RA: Electromyography in evaluation of the response to muscle relaxants, Muscle Relaxants. Edited by Katz RL. New York, North-Holland, 1975, pp 299-312
94. Kopman AF: The relationship of evoked electromyographic and mechanical responses following atracurium in humans. ANESTHESIOLOGY 1985; 63:208-11
95. Viby-Mogensen J: Neuromuscular monitoring. Anesthesia, 6th edition. Edited by Miller RD. New York, Churchill-Livingstone, 2005, pp 1551-70