Cystic hygromas, nuchal edema, and nuchal translucency at 11-14 weeks of gestation

Obstetrics and Gynecology

Volumn 107, Issue 3, 2006, Pages 678-683

  Molina, Francisca S ^a   Avgidou, Kyriaki ^a   Kagan, Karl Oliver ^a   Poggi, Sara ^a   Nicolaides, Kypros H ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME DISORDER; CYSTIC LYMPHANGIOMA; DISEASE ASSOCIATION; FETUS; FETUS ECHOGRAPHY; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; KARYOTYPE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; NECK; NUCHAL TRANSLUCENCY MEASUREMENT; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; SCREENING TEST; SPINE; TRISOMY 13; TRISOMY 18; TRISOMY 21; TURNER SYNDROME;

ADULT; CHROMOSOME DISORDERS; FEMALE; HUMANS; HYDROPS FETALIS; KARYOTYPING; LYMPHANGIOMA, CYSTIC; MIDDLE AGED; NUCHAL TRANSLUCENCY MEASUREMENT; PREGNANCY; PREGNANCY TRIMESTER, FIRST; REGRESSION ANALYSIS;

EID: 33646779160     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.AOG.0000201979.23031.32     Document Type: Article

References (24)

1. Chervenak FA, Isaacson G, Blakemore KJ, Breg RW, Hobbins JC, Berkowitz RL, et al. Fetal cystic hygroma: cause and natural history. N Engl J Med 1983;309:822-5.
2. Azar G, Snijders RJM, Gosden CM, Nicolaides KH. Fetal nuchal cystic hygromata: associated malformations and chromosomal defects. Fetal Diagn Ther 1991;6:46-57.
3. Benacerraf BR, Gelman R, Frigoletto FD. Sonographic identification of second-trimester fetuses with Down's syndrome. N Engl J Med 1987;317:1371-6.
4. Nicolaides KH, Azar G, Snijders RJM, Gosden CM. Fetal nuchal edema: associated malformations and chromosomal defects. Fetal Diagn Ther 1992;7:123-31.
5. Van der Putte SCJ. Lymphatic malformation in human fetuses: a study of fetuses with Turner's syndrome or status Bonnevie-Ullrich. Virchows Arch A Pathol Anat Histol 1977;376:233-46.
6. Pons JC, Diallo AA, Eydoux P, Rais S, Doumerc S, Frydman R, Papiernik E. Chorionic villus sampling after first trimester diagnosis of fetal cystic hygroma Colli. Eur J Obstet Gynecol Reprod Biol 1989;33:141-6.
7. Cullen MT, Gabrielli S, Green JJ, Rizzo N, Mahoney MJ, Salafia C, et al. Diagnosis and significance of cystic hygroma in the first trimester. Prenat Diagn 1990;10:643-51.
8. MacLeod AM, McHugo JM. Prenatal diagnosis of nuchal cystic hygroma. Br J Radiol 1991;64:802-7.
9. Shulman LP, Emerson D, Felker R, Phillips O, Simpson J, Elias S. High frequency of cytogenetic abnormalities with cystic hygroma diagnosed in the first trimester. Obstet Gynecol 1992;80:80-2.
10. Suchet IB, van der Westhuizen NG, Labatte MF. Fetal cystic hygromas: further insights into their natural history. Can Assoc Radiol J 1992;43:420-4.
11. Van Zalen-Sprock MM, van Vugt JMG, van Geijn HP. First-trimester diagnosis of cystic hygroma: course and outcome. Am J Obstet Gynecol 1992;167:94-8.
12. Ville Y, Borghi E, Pons JC, Lelorc'h M. Fetal karyotype from cystic hygroma fluid. Prenat Diagn 1992;12:139-43.
13. Johnson MP, Johnson A, Holzgreve W, Isada NB, Wapner RJ, Treadwell MC, et al. First-trimester simple hygroma: cause and outcome. Am J Obstet Gynecol 1993;168:156-61.
14. Nadel A, Bromley B, Benacerraf BR. Nuchal thickening or cystic hygromas in first- and early second-trimester fetuses: prognosis and outcome. Obstet Gynecol 1993;82:43-8.
15. Trauffer ML, Anderson CE, Johnson A, Heeger S, Morgan P, Wapner RJ. The natural history of euploid pregnancies with first-trimester cystic hygromas. Am J Obstet Gynecol 1994;170:1279-84.
16. Nicolaides KH, Azar G, Byrne D, Mansur C, Marks K. Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy. Br Med J 1992;304:867-89.
17. Souka AP, Snidjers RJM, Novakov A, Soares W, Nicolaides KH. Defects and syndromes in chromosomally normal fetuses with increased nuchal translucency thickness at 10-14 weeks of gestation. Ultrasound Obstet Gynecol 1998;11:391-400.
18. Souka AP, Von Kaisenberg CS, Hyett JA, Sonek JD, Nicolaides KH. Increased nuchal translucency with normal karyotype. Am J Obstet Gynecol 2005;192:1005-21.
19. Snijders RJM, Noble P, Sebire N, Souka A, Nicolaides KH. UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal translucency thickness at 10-14 weeks of gestation: Fetal Medicine Foundation First Trimester Screening Group. Lancet 1998;351:343-6.
20. Nicolaides KH. Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities. Am J Obstet Gynecol 2004;191:45-67.
21. Kagan KO, Avgidou K, Molina FS, Gajewska K, Nicolaides KH. Relation between increased fetal nuchal translucency thickness and chromosomal defects. Obstet Gynecol 2006;107:6-10.
22. Malone FD, Ball RH, Nyberg DA, Comstock CH, Saade GR, Berkowitz RL, et al. First-trimester septated cystic hygroma: prevalence, natural history, and pediatric outcome. Obstet Gynecol 2005;106:288-94.
23. Avgidou K, Papageorghiou A, Bindra R, Spencer K, Nicolaides KH. Prospective first-trimester screening for trisomy 21 in 30,564 pregnancies. Am J Obstet Gynecol 2005;192:1761-7.
24. Nicolaides KH, Spencer K, Avgidou K, Faiola S, Falcon O. Multicenter study of first-trimester screening for trisomy 21 in 75,821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening. Ultrasound Obstet Gynecol 2005;25:221-6.