Study on the determinants of suckling mice neurovirulence of dengue 2 virus

Science in China, Series C: Life Sciences

Volumn 46, Issue 1, 2003, Pages 95-103

  Zhao, Wei ^a   Fan, Baochang ^a   Hu, Zhijun ^a   Chen, Suiping ^a   Wang, Pengcheng ^a   Yuan, Xitong ^a   Li, Xiaoyu ^a   Yu, Man ^a   Qin, Ede ^a   Yang, Peiying ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Dengue 2 virus; Infectious transcripts; Point mutation; Virulent determinants

Indexed keywords

DENGUE 2 VIRUS; INFECTIOUS TRANSCRIPTS; POINT MUTATION; VIRULENT DETERMINANTS;

CELLS; CLONING; NEUROLOGY; PROTEINS; VIRUSES;

DISEASES;

PRIMER DNA; VIRUS DNA;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL LINE; CLASSIFICATION; CYTOPATHOGENIC EFFECT; DENGUE; DENGUE VIRUS; DISEASE MODEL; GENETICS; HAMSTER; MOUSE; NUCLEOTIDE SEQUENCE; PATHOGENICITY; SITE DIRECTED MUTAGENESIS; SUCKLING; VIROLOGY; VIRULENCE; VIRUS ENCEPHALITIS; VIRUS GENE;

ANIMALS; ANIMALS, SUCKLING; BASE SEQUENCE; CELL LINE; CRICETINAE; CYTOPATHOGENIC EFFECT, VIRAL; DENGUE; DENGUE VIRUS; DISEASE MODELS, ANIMAL; DNA PRIMERS; DNA, VIRAL; ENCEPHALITIS, VIRAL; GENES, VIRAL; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; VIRULENCE;

DENGUE VIRUS; DENGUE VIRUS GROUP; DENGUE VIRUS TYPE 2;

EID: 33646773203     PISSN: 10069305     EISSN: None     Source Type: Journal    
DOI: 10.1360/03yc9011     Document Type: Article

References (15)

1. Qin, E. D., Yu, M., Wang, P. C. et al., Isolation and identification of the pathogen in a recent outbreak of dengue fever in China, Bull. Acad. Mil. Med. Sci. (in Chinese), 2000, 24(1): 56.
2. Johnson, A. J., Roehreg, J. T., New mouse model for dengue virus vaccine testing, J. Virol., 1999,73(1): 783-786.
3. Zhao, W., Hu, Z. J., Yang, J. et al., The genomic sequence determination and virulent gene analysis of the E protein of three dengue 2 virus strains isolated in China, Chinese J. Zoonoses (in Chinese), 2001, 17(1): 10-14.
4. Gualano, R. C., Pryor, M. J., Cauchi, M. R. et al., Identification of a major determinant of mouse neurovirulence of dengue virus type 2 using stably cloned genomic-Iength cDNA, J. Gen. Virol., 1998, 79(3): 437-446.
5. Zhao, W., Hu, Z. J., Yang, P. Y. et al., OL-PCR for site-directed mutagenesis of full-length cDNA clone of DEN-2, Chinese Journal of Microbiology and Immunology (in Chinese), 2001, 21(6): 662-665.
6. Yang, J., Yang, P. Y., Qin, E. D. et al., Sequence analysis of the 5′ and 3′ terminal regions of dengue type 2 virus 04 strain, Chinese J. Exp. Clin. Virol. (in Chinese), 2000, 14(1): 24-26.
7. Yang, P. Y., Qin, E. D., Dengue Fever and Dengue Haemorrhagic Fever (in Chinese), 1st ed., Beijing: People's Military Press, 1999, 177-182.
8. Key, F. A., Heinz, F. X., Mandl, C. et al., The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution, Nature, 1995, 375(6529): 291-298.
9. Lewis, J. A., Chang, G. -J., Lanciotti, R. S. et al., Phylogenetic relationships of dengue-2 viruses, Virology, 1993, 197(1): 216-224.
10. Pandey, B. D., Igarashi, A., Severity-related molecular differences among nineteen strains of dengue type 2 viruses, Microbiol. Immunol., 2000, 44(3): 179-188.
11. Leitmeyer, K. C., Vaughn, D. W., Watts, D. M. et al., Dengue virus structural differences that correlate with pathogenesis, J. Virol., 1999, 73(6): 4738-4747.
12. Boyer, J. -C., Haenni, A. -L., Infectious transcripts and cDNA clones of RNA viruses, Virology, 1994, 198(2): 415-426.
13. Lai, C. -J., Zhao, B., Hori, H. et al., Infectious RNA transcribed from stably cloned full-length cDNA of dengue type 4 virus, Proc. Natl. Acad. Sci., 1991, 88(12): 5139-5143.
14. Zhao, W., Yang, P. Y., Advance in study on the virulence of dengue virus, Chinese J. Exp. Clin. Virol. (in Chinese), 2001, 15(2): 126-128.
15. Butrapet, S., Huang, C. Y., Pierro, D. J. et al., Attenuation markers of a candidate dengue type 2 vaccine virus, strain 16681 (PDK-53), are defined by mutations in the 5′ noncoding region and nonstructural proteins 1 and 3, J. Virol., 2000, 74(7): 3011-3019.