Influence of rheological behaviour of particulate/polymer dispersions on liquid-filling characteristics for hard gelatin capsules

International Journal of Pharmaceutics

Volumn 316, Issue 1-2, 2006, Pages 74-85

  Kattige, A ^a   Rowley, G ^a  

^a UNIVERSITY OF SUNDERLAND   (United Kingdom)

Author keywords

Capsule filling; Poloxamer; Rheology; Solid dispersion; Thixotropy

Indexed keywords

2 AMINO 2 METHYL 3 (2 TRIFLUOROMETHYL 5 BENZIMIDAZOLYL)PROPIONIC ACID; GELATIN; LACTOSE; POLOXAMER;

ARTICLE; CAPSULE FILLING; DISPERSION; FLOW KINETICS; PARTICLE SIZE; PRIORITY JOURNAL; SHEAR FLOW; THIXOTROPY; VISCOSITY;

CAPSULES; DRUG COMPOUNDING; GELATIN; LACTOSE; POLOXAMER; RHEOLOGY; VISCOSITY;

EID: 33646772885     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.02.036     Document Type: Article

References (22)

1. Barnes H.A. A Handbook of Elementary Rheology (2000), The University of Wales Institute of Non-Newtonian Fluid Mechanics, Wales
2. Betagiri G.V., and Makarla K.R. Enhancement of dissolution of glyburide by solid dispersion and lyophilization techniques. Int. J. Pharm. 126 (1995) 155-160
3. Carrimed, 1995. Instruction manual for the Carri-med CSL controlled stress rheometer.
4. Cogswell F.N. Polymer Melt Rheology (1981), John Wiley and Sons, New York
5. Ellison, M.J.H., 1997. An Investigation of the Physicochemical and Rheological Properties of Drug-Gel Formulations in Relation to Drug Release Mechanisms. PhD Thesis, University of Sunderland.
6. Hawley, A.R., 1993. Investigation of Thermosoftened Solid Dispersion Formulations of Ibuprofen for Hard Gelatin Capsules. PhD Thesis, University of Sunderland.
7. Hawley A.R., Rowley G., Lough W.J., and Chatham S.M. The physical and chemical characterization of thermosoftened bases for molten filled hard gelatin capsules. Drug. Dev. Ind. Pharm. 18 (1992) 1719-1739
8. ICI Surfactants, 1994. Technical Data, Alkoxylates and Polyglycols Range.
9. Kattige A., and Rowley G. The effects of particulate disperse phase on aeration and filling of semi-solid matrices in hard gelatin capsules. J. Pharm. Pharmacol. 51 (1999) 285
10. Kattige, A., 2001. The Effects of Particulate Phase on Rheology and Capsule Filling of Poloxamer Dispersions. PhD Thesis, University of Sunderland.
11. Metzner A.B. Rheology of suspensions in polymeric liquids. J. Rheol. 29 (1985) 739-775
12. Probstein R.F., Sengun M.Z., and Tseng T.C. Bimodal model of concentrated suspension viscosity for distributed particle sizes. J. Rheol. 38 (1994) 811-829
13. Rowley G. Filling of Liquids and Semi-solids into Two-piece Capsules, Chapter 9, Pharmaceutical Capsules. 2nd ed. (2004), Pharmaceutical Press, UK
14. Rowley G., Hawley A.R., Dobson C.L., and Chatham S. Rheology and filling characteristics of particulate dispersions in polymer melt formulations for liquid-fill hard gelatin capsules. Drug Dev. Ind. Pharm. 24 (1998) 605-611
15. Saeed, T., 1999. Rheological Characterization of Poloxamer/Silicon dioxide Gels for Liquid-Filled Hard Gelatin Capsules. PhD Thesis, University of Sunderland.
16. Song J.H., and Evans J.R.G. Flocculation after injection molding in ceramic suspensions. J. Mater. Res. 9 (1994) 2386-2397
17. Song J.H., and Evans J.R.G. The assessment of dispersion of fine ceramic powders for injection moulding and related processes. J. Eur. Ceram. Soc. 12 (1993) 467-478
18. Sutananta W., Craig D.Q.M., and Newton J.M. An evaluation of the mechanisms of drug-release from glyceride bases. J. Pharm. Pharmacol. 47 (1995) 182-187
19. Walker S.E., Ganley J.A., Bedford K., and Eaves T. The filling of molten and thixotropic formulations into hard gelatin capsules. J. Pharm. Pharmacol. 32 (1980) 389-393
20. Walters P.A., Rowley G., Pearson J.T., and Taylor C.J. Formulation and physical properties of thixotropic gels for hard gelatin capsules. Drug Dev. Ind. Pharm. 18 (1992) 1613-1631
21. Zettlemoyer A.C., and Lower G.M. The rheology of printing inks. III. Studies of simple dispersions. J. Colloid Sci. 10 (1955) 29-45
22. 2 suspensions in low molecular polymer solution. Prog. Org. Coat. 30 (1997) 67-78