Left ventricular diastolic filling characteristics are not impaired but systolic performance was augmented in the early hours of experimental endotoxemia in humans

Shock

Volumn 25, Issue 4, 2006, Pages 338-343

  Mathru, Mali ^a   Pollard, Valerie ^b   He, Gy ^b   Varma, Tushar K ^b   Ahmad, Masood ^b   Prough, Donald S ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Diastolic cardiac dysfunction; Diastolic function; E. coli endotoxin; Human endotoxemia; Sepsis; Tissue Doppler

Indexed keywords

ESCHERICHIA COLI ENDOTOXIN;

ADULT; ARTICLE; CLINICAL ARTICLE; ENDOTOXEMIA; FEMALE; HEART AFTERLOAD; HEART ATRIUM CONTRACTILITY; HEART ATRIUM CONTRACTION; HEART DISEASE; HEART INDEX; HEART LEFT VENTRICLE FILLING; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; M MODE ECHOCARDIOGRAPHY; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; SYMPATHETIC TONE; SYSTOLIC BLOOD PRESSURE; TRANSTHORACIC ECHOCARDIOGRAPHY; TWO DIMENSIONAL ECHOCARDIOGRAPHY;

ADULT; DIASTOLE; ENDOTOXINS; FEMALE; HEART VENTRICLES; HUMANS; MALE; SYSTOLE; VENTRICULAR FUNCTION;

EID: 33646766823     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000209523.05249.27     Document Type: Article

References (47)

1. Dhainaut J-F, Cariou A, Laurent I: Myocardial dysfunction in sepsis. Sepsis 89-97, 2000.
2. Parker MM, Sufredini AF, Natanson C, Ognibene FP, Shelhamer JH, Parrillo JE: Responses of left ventricular function in survivors and nonsurvivors of septic shock. J Crit Care 4:19-25, 1989.
3. Sufredine AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesley RA, Parrillo JE: The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 321:280-287, 1989.
4. Parker MM, Shelhamer JH, Bacharach SL: Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 100:483-490, 1984.
5. Poelaert J, Declerck C, Vogelaers D, Colardyn F, Visser CA: Left ventricular systolic and diastolic function in septic shock. Intensive Care Med 23:553-560, 1997.
6. Meng X, AO L, Meldrum DR, Cain BS, Shames BD, Selzman CH, Banerjee A, Harken AH: TNF-α and myocardial depression in endotoxemic rats: temporal discordance of an obligatory relationship. Am J Physiol 275:R502-R508, 1998.
7. Munt B, Jue J, Gin K, Fenwick J, Tweeddale M: Diastolic filling in human severe sepsis: an echocardiographic study. Crit Care Med 26:1829-1833, 1998.
8. Raper R, Sibbald WJ, Driedger AA, Gerow K: Relative myocardial depression in normotensive sepsis. J Crit Care 4:9-18, 1989.
9. Artucio H, Digenio A, Pereyra M: Left ventricular function during sepsis. Crit Care Med 17:323-327, 1989.
10. Raper RF, Sibbald WJ: The effects of coronary artery disease on cardiac function in non hypotensive sepsis. Chest 94:507-511, 1988.
11. Dhainaut J-F, Lanore JJ, DeGournay JM, Huyghebaert MG, Brunet F, Villemant D, Monsallier JF: Right ventricular dysfunction in patients with septic shock. Intensive Care Med 14:488-491, 2004.
12. Kimchi A, Ellrody AG, Berman DS: Right ventricular performance in septic shock: a combined radionuclide and hemodynamic study. J Am Coll Cardiol 4:945, 1984.
13. Soble JS: Doppler "diastology": a new twist to the study of sepsis. Crit Care Med 26:1777-1778, 1998.
14. Raetz CRH, Ulevitch RJ, Wright SC, Sibley CH, Ding A, Nathan CF: Gram-negative endotoxin: An extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J 5:2652-2660, 1991.
15. Wolff SM: Biological effects of bacterial endotoxins in man. J Infect Dis 128(suppl):259-264, 1973.
16. Suffredine AF: Endotoxin administration to humans: a model of inflammatory responses relevant to sepsis. In Mediators of Sepsis. New York: Springer-Verlag, pp 13-30, 1992.
17. Hare JM, Colucci WS: Role of nitric oxide in the regulation of myocardial function. Prog Cardiovasc Dis 38:155-166, 1995.
18. Gomez-Jimenez J, Salgado A, Mourelle M, Martin MC, Segura RM, Peracaula R, Mondada Salvador M: L-Arginine: nitric oxide pathway in endotoxemia and human septic shock. Crit Care Med 23:253-258, 1995.
19. Zhong J, Rubin LJ, Parker JL, Adams HR: Cardiodynamic response to Escherichia coli endotoxemia: effects of fluid resuscitation. Shock 2:203-209, 1994.
20. Meldrum DR: Tumor necrosis factor in the heart. Am J Physiol 274:R577-R595, 1998.
21. Sohn DW, Chai IH, Lee DJ, Kim HC, Kim HS, Oh BH, Lee MM, Park YB, Choi YS, Seo JD, Lee YW: Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function. J Am Coll Cardiol 30:474-480, 1997.
22. Oki T, Tabata T, Yamada H, Wakatsuki T, Shinohara H, Nishikado A, Iuchi A, Fukuda N, Ito S: Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation. Am J Cardiol 79:921-928, 1997.
23. Schiller NB: Analysis of left ventricular systolic function. Heart 75:17-26, 1996.
24. Jardin F, Gueret P, Prost JF, Farcot JC, Ozier Y, Bourdarias JP: Two-dimensional echocardiographic assessment of left ventricular function in chronic obstructive pulmonary disease. Am Rev Respir Dis 129:135-142, 1984.
25. Neumann A, Soble JS, Anagnos PC, Kagzi M, Parrillo JE: Accurate noninvasive estimation of left ventricular end-diastolic pressure: comparison with catheterization. J Am Soc Echocardiogr 11:126-131, 1998.
26. Scalia GM, Greenberg NL, McCarthy PM, Thomas JD, Vandervoort PM: Noninvasive assessment of the ventricular relaxation time constant (tau) in humans by Doppler echocardiography. Circulation 95:151-155, 1997.
27. GraphPad Software, Inc; 2005.
28. Godin PJ, Fleisher LA, Eidsath A, Vandivier RW, Preas HL, Banks SM, Buchman TG, Suffredini AF: Experimental human endotoxemia increases cardiac regularity: results from a prospective, randomized, crossover trial. Crit Care Med 24:1117-1124, 1996.
29. Godin PJ, Buchman TG: Uncoupling of biological oscillators: a complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 24:1107-1116, 1996.
30. Garcia-Fernandez MA, Azevedo J, Moreno M, Bermejo J, Perez-Castellano N, Puerta P, Desco M, Antoranz C, Serrano JA, Garcia E: Regional diastolic function in ischaemic heart disease using pulsed wave Doppler tissue imaging. Eur Heart J 20:496-505, 1999.
31. Yamada H, Oki T, Mishiro Y, Tabata T, Abe M, Onose Y, Wakatsuki T, Ito S: Effect of aging on diastolic left ventricular myocardial velocities measured by pulsed tissue Doppler imaging in healthy subjects. J Am Soc Echocardiogr 12:574-581, 1999.
32. Firstenberg MS, Greenberg NL, Main ML, Drinko JK, Odabashian JA, Thomas JD, Garcia MJ: Determination of diastolic myocardial tissue Doppler velocities influences of relaxation and preload. J Appl Physiol 90:299-307, 2001.
33. Thomas JD, Flachskampf FA, Chen C, Guererro JL, Picard MH, Levine RA, Weyman AE: Isovolumic relaxation time varies predictably with its time constant and aortic and left atrial pressures: implications for the noninvasive evaluation of ventricular relaxation. Am Heart J 124:1305-1313, 1992.
34. Slutsky R, Karliner J, Gerber K, Battler A, Froelicher V, Gregoratos G, Peterson K, Ashburn W: Peak systolic blood pressure/end-systolic volume ratio: assessment at rest and during exercise in normal subjects and patients with coronary heart disease. Am J Cardiol 46:813-820, 1980.
35. Sekido M, Uemura R, Takayama M, Kiuchi K, Nejima J, Takano T: Left ventricular peak systolic pressure/end-systolic volume ratio change after dobutamine infusion for predicting left ventricular contractile reserve: comparison with Emax. J Cardiol 39:75-84, 2002.
36. Chendrasekhar A, Barringer LS, Fagerli JC, Dulaney J, Pillai S, Timberlake GA: Load-independent left ventricular function in a hemorrhagic shock model. J Surg Res 62:49-52, 1996.
37. DeMeules JE, Pigula FA, Mueller M, Raymond SJ, Gamelli RL: Tumor necrosis factor and cardiac function. J Trauma 32:686-692, 1992.
38. Moser KM, Perry RB, Luchsinger PC: Cardiopulmonary consequences of pyrogen-induced hyperexia in man. J Clin Invest 42:626-634, 1963.
39. Pinsky MR, Rico P: Cardiac contractility is not depressed in early canine endotoxic shock. Am J Respir Crit Care Med 161:1087-1093, 2000.
40. Kumar A, Bunnell E, Lynn M, Anel R, Habet K, Neumann A, Parrillo JE: Experimental human endotoxemia is associated with depression of load-independent contractility indices: prevention by the lipid a analogue E5531. Chest 126:860-867, 2004.
41. Kumar A, Anel R, Bunnell E, Habet K, Neumann A, Wolff D, Rosenson R, Cheang M, Parrillo JE: Effect of large volume infusion on left ventricular volumes, performance and contractility parameters in normal volunteers. Intensive Care Med 30:1361-1369, 2004.
42. Opal SM: The clinical relevance of endotoxin in human sepsis: a critical analysis. J Endotoxin Res 8:473-476, 2002.
43. O'Brien JM Jr, Abraham E: Human models of endotoxemia and recombinant human activated protein C. Crit Care Med 32:S202-S208, 2004.
44. Jafri SM, Lavine S, Field BE, Bahorozian MT, Carlson RW: Left ventricular diastolic function in sepsis. Crit Care Med 18:709-714, 1990.
45. Gorcsan J III, Strum DP, Mandarino WA, Gulati VK, Pinsky MR: Quantitative assessment of alterations in regional left ventricular contractility with color-coded tissue Doppler echocardiography. Comparison with sonomicronmetry and pressure-volume relations. Circulation 95:2423-2433, 1997.
46. Lattik R, Couture P, Denault AY, Carrier M, Harel F, Taillefer J, Tardif JC: Mitral Doppler indices are superior to two-dimensional echocardiographic and hemodynamic variables in predicting responsiveness of cardiac output to a rapid intravenous infusion of colloid. Anesth Analg 94:1092-1099, 2002.
47. Swenson JD, Harkin C, Pace NL, Astle K, Bailey P: Transesophageal echocardiography: an objective tool in defining maximum ventricular response to intravenous fluid therapy. Anesth Analg 83:1149-1153, 1996.