Azathioprine and inhibition of the anticoagulant effect of warfarin: Evidence from a case report and a literature review

American Journal Geriatric Pharmacotherapy

Volumn 4, Issue 1, 2006, Pages 75-77

  Joo Ng, Heng ^a,b   Crowther, Mark A ^a  

^a ST JOSEPH S HOSPITAL   (Canada)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

anticoagulation; azathioprine; case report, drug interaction; inhibitory interaction; warfarin

Indexed keywords

AZATHIOPRINE; CALCITRIOL; HYDROMORPHONE; OMEPRAZOLE; PREDNISONE; RISEDRONIC ACID; VITAMIN D; WARFARIN; ZOPICLONE;

AGED; ANTICOAGULATION; ARTICLE; CASE REPORT; DEEP VEIN THROMBOSIS; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG INHIBITION; DRUG WITHDRAWAL; EVIDENCE BASED MEDICINE; FEMALE; HUMAN; INTERNATIONAL NORMALIZED RATIO; MEDICAL LITERATURE; PATIENT MONITORING; PRIORITY JOURNAL; RECURRENT DISEASE; SYSTEMIC LUPUS ERYTHEMATOSUS;

AGED; ANTICOAGULANTS; AZATHIOPRINE; DRUG ANTAGONISM; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERNATIONAL NORMALIZED RATIO; LUPUS ERYTHEMATOSUS, SYSTEMIC; VENOUS THROMBOSIS; WARFARIN;

EID: 33646766148     PISSN: 15435946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjopharm.2006.03.001     Document Type: Article

References (10)

1. Singleton J.D., and Conyers L. Warfarin and azathioprine: An important drug interaction. Am J Med 92 (1992) 217
2. Rivier G., Khamashta M.A., and Hughes G.R. Warfarin and azathioprine: A drug interaction does exist. Am J Med 95 (1993) 342
3. Havrda D.E., Rathbun S., and Scheid D. A case report of warfarm resistance due to azathioprine and review of the literature. Pharmacotherapy 21 (2001) 355-357
4. [published correction appears in Ann Pharmacother. 2001;35:1296]. Rotenberg M., Levy Y., Shoenfeld Y., et al. Effect of azathioprine on the anticoagulant activity of warfarin. Ann Pharmacother 34 (2000) 120-122
5. Walker J., Mendelson H., McClure A., and Smith M.D. Warfarin and azathioprine: Clinically significant drug interaction. J Rheumatol 29 (2002) 398-399
6. Wells P.S., Holbrook A.M., Crowther N.R., and Hirsh J. Interactions of warfarin with drugs and food. Ann Intern Med 121 (1994) 676-683
7. Castellino G., Cuadrado M.J., Godfrey T., et al. Characteristics of patients with antiphospholipid syndrome with major bleeding after oral anticoagulant treatment. Ann Rheum Dis 60 (2001) 527-530
8. Spiers A.S., and Mibashan R.S. Letter: Increased warfarin requirement during mercaptopurine therapy: A new drug interaction. Lancet 2 (1974) 221-222
9. Fernandez M.A., Regadera A., and Aznar J. Acenocoumarol and 6-mercaptopurine: An important drug interaction. Haematologica 84 (1999) 664-665
10. Naranjo C.A., Busto U., Sellers E.M., et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30 (1981) 239-245