Specific amino acids increase mucin synthesis and microbiota in dextran sulfate sodium-treated rats

Journal of Nutrition

Volumn 136, Issue 6, 2006, Pages 1558-1564

  Faure, Magali ^a   Mettraux, Christine ^a   Moennoz, Denis ^a   Godin, Jean Philippe ^a   Vuichoud, Jacques ^a   Rochat, Florence ^a   Breuillé, Denis ^a   Obled, Christiane ^b   Corthésy Theulaz, Irène ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

^b CEMAGREF   (France)

Author keywords

Amino acids; Intestine; Mucin; Protein synthesis; Rats

Indexed keywords

AMINO ACID DERIVATIVE; CYSTEINE; DEXTRAN SULFATE; MUCIN; PROLINE; SERINE; THREONINE;

AMINO ACID COMPOSITION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; GOBLET CELL; INTESTINE EPITHELIUM; MALE; NONHUMAN; PROTEIN METABOLISM; RAT; ULCERATIVE COLITIS;

BACTERIA (MICROORGANISMS);

EID: 33646764950     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.6.1558     Document Type: Article

References (33)

1. Forstner JF, Oliver MG, Sylvester FA. Production, structure and biologic relevance of gastrointestinal mucins. In: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL, editors. Infections of the gastrointestinal tract. New York: Raven Press; 1995. p. 71-88.
2. Jenkins RT, Ramage JK, Jones DB, Collins SM, Goodacre RL, Hunt RH. Small bowel and colonic permeability to 51Cr-EDTA in patients with active inflammatory bowel disease. Clin Invest Med. 1988;11:151-5.
3. Arslan G, Atasever T, Cindoruk M, Yildirim IS. (51)CrEDTA colonic permeability and therapy response in patients with ulcerative colitis. Nucl Med Commun. 2001;22:997-1001.
4. Seksik P, Rigottier-Gois L, Gramet G, Sutren M, Pochart P, Marteau P, Jian R, Dore J. Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon. Gut. 2003;52:237-42.
5. Mahida YR, Rolfe VE. Host-bacterial interactions in inflammatory bowel disease. Clin Sci (Lond). 2004;107:331-41.
6. Macfarlane S, Furrie E, Cummings JH, Macfarlane GT. Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis. Clin Infect Dis. 2004;38:1690-9.
7. Ott SJ, Musfeldt M, Wenderoth DF, Hampe J, Brant O, Folsch UR, Timmis KN, Schreiber S. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut. 2004;53:685-93.
8. Corfield AP, Myerscough N, Longman R, Sylvester P, Arul S, Pignatelli M. Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut. 2000;47:589-94.
9. Tytgat KM, Van der Wal JW, Einerhand AW, Buller HA, Dekker J. Quantitative analysis of MUC2 synthesis in ulcerative colitis. Biochem Biophys Res Commun. 1996;224:397-405.
10. Weiss AA, Babyatsky MW, Ogata S, Chen A, Itzkowitz SH. Expression of MUC2 and MUC3 mRNA in human normal, malignant, and inflammatory intestinal tissues. J Histochem Cytochem. 1996;44:1161-6.
11. Fuller MF, Milne A, Harris CI, Reid TM, Keenan R. Amino acid losses in ileostomy fluid on a protein-free diet. Am J Clin Nutr. 1994;59:70-3.
12. Stoll B, Henry J, Reeds PJ, Yu H, Jahoor F, Burrin DG. Catabolism dominates the first-pass intestinal metabolism of dietary essential amino acids in milk protein-fed piglets. J Nutr. 1998;128:606-14.
13. Faure M, Moennoz D, Montigon F, Mettraux C, Breuille D, Ballevre O. Dietary threonine restriction specifically reduces intestinal mucin synthesis in rats. J Nutr. 2005;135:486-91.
14. Heys SD, Park KG, McNurlan MA, Keenan RA, Miller JD, Eremin O, Garlick PJ. Protein synthesis rates in colon and liver: stimulation by gastrointestinal pathologies. Gut. 1992;33:976-81.
15. Breuille D, Arnal M, Rambourdin F, Bayle G, Levieux D, Obled C. Sustained modifications of protein metabolism in various tissues in a rat model of long-lasting sepsis. Clin Sci (Lond). 1998;94:413-23.
16. Mercier S, Breuille D, Mosoni L, Obled C, Patureau MP. Chronic inflammation alters protein metabolism in several organs of adult rats. J Nutr. 2002;132:1921-8.
17. El Yousfi M, Breuille D, Papet I, Blum S, André M, Mosoni L, Denis P, Buffière C, Obled C. Increased tissue protein synthesis during spontaneous colitis in HLA-B27 rats implies different underlying mechanisms. Clin Sci (Lond). 2003;105:437-46.
18. Breuille D, Bechereau F, Buffiere C, Denis P, Pouyet C, Obled C. Beneficial effect of amino acid supplementation, especially cysteine, on body nitrogen economy in septic rats. Clin Nutr. 2005 Dec 29.
19. Faure M, Choné F, Béchereau F, Godin JP, Papet I, Breuillé D, Obled C. Threonine utilization in the gut during sepsis. Clin.Nutr. 23 ed. 2004. p. 807.
20. Neutra MR, Forstner JF. Gastrointestinal mucus: synthesis, secretion and function. In: Leonard R.Johnson, editor. Physiology of the gastrointestinal tract. New York: Raven Press; 1987. p. 975-1009.
21. Faure M, Moennoz D, Montigon F, Fay LB, Breuillé D, Finot PA, Ballevre O, Boza J. Development of a rapid and convenient method to purify mucins and determine their in vivo synthesis rate in rats. Anal Biochem. 2002;307:244-51.
22. Faure M, Moennoz D, Montigon F, Mettraux C, Mercier S, Schiffrin EJ, Obled C, Breuille D, Boza J. Mucin production and composition is altered in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci. 2003;48:1366-73.
23. Faure M, Moennoz D, Mettraux C, Montigon F, Schiffrin EJ, Obled C, Breuille D, Boza J. The chronic colitis developed by HLA-B27 transgenic rats is associated with altered in vivo mucin synthesis. Dig Dis Sci. 2004;49:339-46.
24. Rieu I, Sornet C, Bayle G, Prugnaud J, Pouyet C, Balage M, Papet I, Grizard J, Dardevet D. Leucine-supplemented meal feeding for ten days beneficially affects postprandial muscle protein synthesis in old rats. J Nutr. 2003;133:1198-205.
25. Garlick PJ, McNurlan MA, Preedy VR. A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine. Biochem J. 1980;192:719-23.
26. Guigoz Y, Rochat F, Perruisseau-Carrier G, Rochat I, Schiffrin EJ. Effects of oligosaccharide on the faecal flora and non-specific immune system in elderly people. Nutr Res. 2002;22:13-25.
27. Schiffrin EJ, El Yousfi K, Faure M, Combaret L, Donnet A, Blum S, Obled C, Breuille D. Milk casein-based diet containing TGF-beta controls the inflammatory reaction in the HLA-B27 transgenic rat model. JPEN J Parenter Enteral Nutr. 2005;29:S141-8.
28. Rousseeuw PJ, Croux C. Alternatives to the median absolute deviation. J Am Stat Assoc. 1993;88:1273-83.
29. Cooper HS, Murthy SN, Shah RS, Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993;69:238-49.
30. Takizawa H, Asakura H, Sasakawa T, Bannai H, Nomoto M. Immunological studies of the mucosa in colitis induced by sodium dextran sulfate in rats. Adv Exp Med Biol. 1995;371B:1383-7.
31. Kim YS, Gum J Jr, Brockhausen I. Mucin glycoproteins in neoplasia. Glycoconj J. 1996;13:693-707.
32. Specian RD, Oliver MG. Functional biology of intestinal goblet cells. Am J Physiol. 1991;260:C183-93.
33. Sonnenburg JL, Angenent LT, Gordon JI. Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? Nat Immunol. 2004;5:569-73.