RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice

Endocrinology

Volumn 147, Issue 6, 2006, Pages 2916-2922

  Moriya, Ryuichi ^a   Sano, Hideki ^a   Umeda, Tatsuya ^a   Ito, Makoto ^a   Takahashi, Yuki ^a   Matsuda, Masao ^a   Ishihara, Akane ^a   Kanatani, Akio ^a   Iwaasa, Hisashi ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUTAMINYLARGINYLPHENYLANALYLPROLINE; INSULIN; LEPTIN; MESSENGER RNA; POLYPEPTIDE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENERGY EXPENDITURE; FEEDING BEHAVIOR; HOMEOSTASIS; HYPERPHAGIA; INSULIN BLOOD LEVEL; LIPID DIET; MALE; MOTOR ACTIVITY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM TEMPERATURE; THERMOGENESIS; WEIGHT GAIN;

ANIMALS; HYPERPHAGIA; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NEUROPEPTIDES; OBESITY; THERMOGENESIS;

EID: 33646757836     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-1580     Document Type: Article

References (13)

1. Dockray GJ 2004 The expanding family of -RFamide peptides and their effects on feeding behaviour. Exp Physiol 89:229-235
2. Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M 2003 A new peptidic ligand and its receptor regulating adrenal function in rats. J Biol Chem 278:46387-46395
3. Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma Jr F, Zhang FL 2003 Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. J Biol Chem 278:27652-27657
4. Chartrel N, Dujardin C, Anouar Y, Leprince J, Decker A, Clerens S, Do-Rego JC, Vandesande F, Llorens-Cortes C, Costentin J, Beauvillain JC, Vaudry H 2003 Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc Natl Acad Sci USA 100:15247-15252
5. Mori T, Baba J, Ichimaru Y, Suzuki T 2000 Effects of rolipram, a selective inhibitor of phosphodiesterase 4, on hyperlocomotion induced by several abused drugs in mice. Jpn J Pharmacol 83:113-118
6. Narita M, Mizuo K, Shibasaki M, Narita M, Suzuki T 2002 Up-regulation of the G(q/11α) protein and protein kinase C during the development of sensitization to morphine-induced hyperlocomotion. Neuroscience 111:127-132
7. Mashiko S, Ishihara A, Iwaasa H, Sano H, Oda Z, Ito J, Yumoto M, Okawa M, Suzuki J, Fukuroda T, Jitsuoka M, Morin NR, MacNeil DJ, Van der Ploeg LHT, Ihara M, Fukami T, Kanatani A 2003 Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of D-Trp34NPY. Endocrinology 144:1793-1801
8. Jump DB, Clarke SD, Thelen A, Liimatta M 1994 Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. J Lipid Res 35:1076-1084
9. Bouillaud F, Ricquier D, Thibault J, Weissenbach J 1985 Molecular approach to thermogenesis in brown adipose tissue: cDNA cloning of the mitochondrial uncoupling protein. Proc Natl Acad Sci USA 82:445-448
10. Nedergaard J, Golozoubova V, Matthias A, Asadi A, Jacobsson A, Cannon B 2001 UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochim Biophys Acta 1504:82-106
11. Minokoshi Y, Saito M, Shimazu T 1986 Sympathetic denervation impairs responses of brown adipose tissue to VMH stimulation. Regul Integr Compar Physiol 251:R1005-R1008
12. Perkins MN, Rothwell NJ, Stock MJ, Stone TW 1981 Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus. Nature 289:401-402
13. Monti JM, Monti D 2000 Role of dorsal raphe nucleus serotonin 5-HT1A receptor in the regulation of REM sleep. Life Sci 66:1999-2012