Nephrotic syndrome associated with hemophagocytic syndrome

Kidney International

Volumn 69, Issue 10, 2006, Pages 1892-1898

  Thaunat, O ^a,d   Delahousse, M ^b   Fakhouri, F ^a   Martinez, F ^a   Stephan, J L ^c   Noel L H ^a   Karras, A ^a,b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b FOCH HOSPITAL   (France)

^c UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

^d INSERM   (France)

Author keywords

Collapsing glomerulopathy; Hemophagocytic syndrome; Hemophagocytosis; Macrophage activation syndrome; Minimal change disease; Nephrotic syndrome

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BLEOMYCIN; CYCLOPHOSPHAMIDE; CYTOKINE; CYTOTOXIC AGENT; DACARBAZINE; DOXORUBICIN; ETOPOSIDE; FERRITIN; GAMMA INTERFERON; HEMOGLOBIN; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VINBLASTINE;

ACUTE KIDNEY FAILURE; ACUTE KIDNEY TUBULE NECROSIS; ADOLESCENT; ADULT; AGED; ANEMIA; ANOREXIA; ARTICLE; AUTOIMMUNE DISEASE; CELL INFILTRATION; CHEDIAK HIGASHI SYNDROME; CHILD; CHILL; CLINICAL ARTICLE; CLINICAL FEATURE; CYTOKINE RELEASE; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; FATIGUE; FEMALE; FEVER; GENETIC SUSCEPTIBILITY; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HEMOPHAGOCYTIC SYNDROME; HUMAN; HUMAN TISSUE; HYPERTRIGLYCERIDEMIA; INFECTION; JUVENILE RHEUMATOID ARTHRITIS; KIDNEY BIOPSY; LABORATORY TEST; LYMPHOMA; MACROPHAGE; MALE; MORTALITY; MULTICENTER STUDY; NEGRO; NEPHROTIC SYNDROME; PODOCYTE; PRACTICE GUIDELINE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPLENOMEGALY; T LYMPHOCYTE ACTIVATION; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; VISCERAL LEISHMANIASIS; WEAKNESS; WEIGHT REDUCTION;

ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; CHILD, PRESCHOOL; CYCLOPHOSPHAMIDE; CYTOKINES; ETOPOSIDE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; MIDDLE AGED; NEPHROTIC SYNDROME; RETROSPECTIVE STUDIES;

EID: 33646701924     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5000352     Document Type: Article

References (15)

1. Imashuku S. Differential diagnosis of hemophagocytic syndrome: underlying disorders and selection of the most effective treatment. Int J Hematol 1997; 66: 135-151.
2. Fujiwara F, Hibi S, Imashuku S. Hypercytokinemia in hemophagocytic syndrome. Am J Pediatr Hematol Oncol 1993; 15: 92-98.
3. Larroche C, Mouthon L. Pathogenesis of hemophagocytic syndrome (HPS). Autoimmun Rev 2004; 3: 69-75.
4. Reiner AP, Spivak JL. Hematophagic histiocytosis. A report of 23 new patients and a review of the literature. Medicine (Baltimore) 1988; 67: 369-388.
5. Henter JI, Blinder G, Ost A. Diagnostic guidelines for hemophagocytic lymphohistiocytosis. The FHL Study Group of the Histiocyte Society. Semin Oncol 1991; 19: 29-33.
6. Scott R. Histiocytic medullary reticulosis. Lancet 1939; 2: 194.
7. Nahum E, Ben-Ari J, Stain J et al. Hemophagocytic lymphohistiocytic syndrome: unrecognized cause of multiple organ failure. Pediatr Crit Care Med 2000; 1: 51-54.
8. Sawhney S, Woo P, Murray KJ. Macrophage activation syndrome: a potentially fatal complication of rheumatic disorders. Arch Dis Child 2001; 85: 421-426.
9. Chiang WC, Wu MS, Tsai CC et al. Thrombotic microangiopathy in hemophagocytic syndrome: a case report. J Formas Med Assoc 2002; 101: 362-367.
10. Braun MC, Cohn RA, Kletzel M. Nephrotic syndrome accompanying familial hemophagocytic syndrome. J Pediatr Hematol Oncol 1996; 18: 195-197.
11. Mansour H, Cheval L, Elalouf JM et al. T-cell transcriptome analysis points up a thymic disorder in idiopathic nephrotic syndrome. Kidney Int 2005; 67: 2168-2177.
12. Akashi K, Hayashi S, Gondo H et al. Involvement of interferon-gamma and macrophage colony-stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults. Br J Haematol 1994; 87: 243-250.
13. McCarthy ET, Sharma R, Sharma M et al. TNF-alpha increases albumin permeability of isolated rat glomeruli through the generation of superoxide. J Am Soc Nephrol 1998; 9: 433-438.
14. Koukouritaki SB, Vardaki EA, Papakonstanti EA et al. TNF-alpha induces actin cytoskeleton reorganization in glomerular epithelial cells involving tyrosine phosphorylation of paxillin and focal adhesion kinase. Mol Med 1999; 5: 382-392.
15. Jordan MB, Hildeman D, Kappler J et al. An animal model of hemophagocytic lymphohistiocytosis (HLH). CD8+ T cells and interferon gamma are essential for the disorder. Blood 2004; 104: 735-743.