Lactacidemia in intrauterine growth restricted (IUGR) pregnancies: Relationship to clinical severity, oxygenation and placental weight

Pediatric Research

Volumn 59, Issue 4 PART 1, 2006, Pages 570-574

  Marconi, Anna Maria ^a   Paolini, Cinzia L ^a   Zerbe, Gary ^b   Battaglia, Frederick C ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID;

ACIDITY; ADULT; ARTICLE; BLOOD PH; CONTROLLED STUDY; DISEASE SEVERITY; EVALUATION; FEMALE; FETUS; FETUS DISEASE; FETUS HEART RATE; FETUS WEIGHT; GESTATIONAL AGE; HUMAN; INTRAUTERINE GROWTH RETARDATION; ITALY; LACTATE BLOOD LEVEL; LACTIC ACIDEMIA; MAJOR CLINICAL STUDY; PLACENTA FUNCTION; PLACENTA WEIGHT; PRIORITY JOURNAL; TISSUE OXYGENATION; UMBILICAL ARTERY; UMBILICAL VEIN;

FEMALE; FETAL GROWTH RETARDATION; FETAL WEIGHT; GESTATIONAL AGE; HUMANS; LACTIC ACID; ORGAN SIZE; OXYGEN; PLACENTA; PREGNANCY;

EID: 33646699800     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000205477.70391.3e     Document Type: Article

References (28)

1. Burd LI, Jones MD Jr., Simmons, MA Makowski EL, Meschia G, Battaglia FC 1975 Placental production and foetal utilisation of lactate and pyruvate. Nature 254:710-711
2. Marconi AM, Cetin I, Ferrazzi E, Ferrari MM, Pardi G, Battaglia FC 1990 Lactate metabolism in normal and growth-retarded human fetuses. Pediatr Res 28:652-656
3. Stembera ZK, Hodr J 1966 The relationship between the blood levels of glucose, lactic acid and pyruvic acid in the mother and in both umbilical vessels of the healthy fetus. Biol Neonat 10:227-238
4. Carstensen MH, Leichtweiss HP, Schroder H 1983 Lactate carriers in artificially perfused human term placenta. Placenta 4:165-174
5. Holzman IR, Philipps AF, Battaglia FC 1979 Glucose metabolism, lactate and ammonia production by the human placenta in vitro. Pediatr Res 13:117-120
6. Sparks JW, Hay WW, Bonds D, Meschia G, Battaglia FC 1982 Simultaneous measurements of lactate turnover rate and umbilical lactate uptake in the fetal lamb. J Clin Invest 70:179-192
7. Gleason CA, Rudolph CD, Bristow J, Itskovitz J, Rudolph AM 1985 Lactate uptake by a fetal sheep liver. J Develop Physiol 7:177-183
8. Suidan JS, Young BK 1984 Outcome of fetuses with lactic acidemia. Am J Obstet Gynecol 150:33-37
9. Suidan JS, Wasserman JF, Young BK 1984 Placental contribution to lactate production by the human fetoplacental unit. Am J Perinatol 1:306-309
10. Kruger K, Hallberg B, Blennow M, Kublickas M, Westgren M 1999 Predictive value of fetal scalp blood lactate concentration and pH as markers of neurologic disability. Am J Obstet Gynecol 181:1072-1078
11. Nordstrom L, Ingemarsson I, Westgren M 1996 Fetal monitoring with lactate. Baillieres Clin Obstet Gynaecol 10:225-242
12. Inuyama M, Ushigome F, Emoto A, Koyabu N, Satoh S, Tsukimori K, Nakano H, Ohtani H, Sawada Y 2002 Characteristics of L-lactic acid transport in basal membrane vesicles of human placental syncytiotrophoblast. Am J Physiol Cell Physiol 283:822-830
13. Balkovetz DF, Leibach FH, Mahesh VB, Ganapathy V 1988 A proton gradient is the driving force for uphill transport of lactate in human placental brush-border membrane vescicles. J Biol Chem 263:13823-13830
14. Deuticke B, Beyer E, Forst B 1982 Discrimination of three parallel pathways of lactate transport in the human erythrocyte membrane by inhibitors and kinetic properties. Biochim Biophys Acta 684:96-110
15. Poole RC, Halestrap AP 1993 Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am J Physiol 264:C761-C782
16. Tiruppathi C, Balkovetz DF, Ganapathy V, Miyamoto Y, Leibach FH 1988 A proton gradient, not a sodium gradient, is the driving force for active transport of lactate in rabbit intestinal brush-border membrane vesicles. Biochem J 256:219-223
17. Ritzhaupt A, Wood IS, Ellis A, Hosie KB, Shirazi-Beechey SP 1998 Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate. J Physiol 513:719-732
18. Wilson MC, Jackson VN, Heddle C, Price NT, Pilegaard H, Juel C, Bonen A, Montgomery I, Hutter OF, Halestrap AP 1998 Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. J Biol Chem 273:15920-15926
19. Bellotti M, Pennati G, De Gasperi C, Bozzo M, Battaglia FC, Ferrazzi E 2004 Simultaneous measurements of umbilical venous, fetal hepatic, and ductus venosus blood flow in growth-restricted human fetuses. Am J Obstet Gynecol 190:1347-1358
20. Parazzini F, Cortinovis I, Bortolus R, Fedele L 1991 Standard di peso alla nascita in Italia. Ann Ost Ginecol Med Perinat 112I:203-246
21. Pardi G, Marconi AM, Cetin I, Lanfranchi A, Bozzetti P, Ferrazzi E, Buscaglia M, Battaglia FC 1993 Diagnostic value of blood sampling in fetuses with growth retardation. N Engl J Med 328:692-696
22. Marconi AM, Paolini C, Buscaglia M, Battaglia FC, Pardi G 1996 The impact of gestational age and fetal growth on the maternal-fetal glucose concentrations difference. Obstet Gynecol 87:937-942
23. Marconi AM, Paolini CL, Stramare L, Cetin I, Fennessey PV, Pardi G, Battaglia FC 1999 Steady state maternal-fetal leucine enrichments in normal and intrauterine growth-restricted pregnancies. Pediatr Res 46:114-119
24. Pardi G, Buscaglia M, Ferrazzi E, Bozzetti P, Marconi AM, Cetin I, Battaglia FC, Makowski EL 1987 Cord sampling for the evaluation of oxygenation and acid-base balance in growth-retarded human fetuses. Am J Obstet Gynecol 157:1221-1228
25. Nicolaides KH, Economides DL, Soothill PW 1989 Blood gases, pH and lactate in appropriate-and small-for-gestational-age fetuses. Am J Obstet Gynecol 161:996-1001
26. Weiner CP 1990 The relationship between the umbilical artery systolic/diastolic ratio and umbilical blood gas measurements in specimens obtained by cordocentesis. Am J Obstet Gynecol 162:1198-202
27. Molteni RA, Stys SJ, Battaglia FC 1978 Relationship of fetal and placental weight in human beings: fetal/placental weight ratios at various gestational ages and birth weight distributions. J Reprod Med 21:327-334
28. Heinonen S, Taipale P, Saarikoski S 2001 Weights of placentae from small-for-gestational age infants revisited. Placenta 22:399-404