Peroral IMUNOR®, a low-molecular-weight immunomodulator prepared from disintegrated and ultrafiltered leukocytes, enhances recovery from myelosuppression induced by cisplatin or 5-fluorouracil

Immunopharmacology and Immunotoxicology

Volumn 28, Issue 1, 2006, Pages 1-11

  Hofer, M ^a   Vacek, A ^a   Hola J ^a   Weiterova L ^a   Streitova D ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

Hematopoiesis; Immunomodulator; IMUNOR ; Myelosuppression

Indexed keywords

CISPLATIN; FLUOROURACIL; IMMUNOMODULATING AGENT; IMUNOR; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; IMMUNOLOGIC FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW SUPPRESSION; CONTROLLED STUDY; DRUG CYTOTOXICITY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IMMUNOMODULATION; LEUKOCYTE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SWINE; TREATMENT OUTCOME; ANIMAL; BONE MARROW CELL; BONE MARROW DISEASE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; FEMALE; GRANULOCYTE; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; STEM CELL; ULTRAFILTRATION;

ANIMALIA; MURINAE; SUS SCROFA;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; BONE MARROW DISEASES; CISPLATIN; FEMALE; FLUOROURACIL; GRANULOCYTES; HEMATOPOIESIS; IMMUNOLOGIC FACTORS; LEUKOCYTES; MICE; MICE, INBRED ICR; STEM CELLS; SWINE; ULTRAFILTRATION;

EID: 33646674480     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.1080/08923970600623525     Document Type: Article

References (21)

1. Fedoročko, P. Liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) promotes hematopoietic recovery in irradiated mice. Int. J. Rad. Biol. 1994, 65, 465-475.
2. Turánek, J.; Záluská, D.; Hofer, M.; Vacek, A.; Ledvina, M.; Ježek J. Stimulation of haemopoiesis and protection of mice against radiation injury by synthetic analogues of muramyldipeptide incorporated in liposomes. Int.J. Immunopharmac. 1997, 19, 611-617.
3. Patchen, M.L.; Liang J.; Vaudrain, T.; Martin, T.; Melican, D.; Zhong, S.; Steward, M.; Queseneberry, P.J. Mobilization of peripheral blood progenitor cells by Betafectin® PGG-glucan alone and in combination with granulocyte colony-stimulating factor. Stem Cells. 1998, 16, 208-217.
4. Hofer, M.; Vacek, A.; Mašek, K.; Juchelková, L.; Pipalová, I. Adamantylamide dipeptide stimulates hematopoiesis and increases survival in irradiated mice. Int. J. Immunopharmac. 2000, 23, 91-97.
5. Pekárek, J.; Čech, K.; Barnet, K. The clinical use of specific transfer factor. In Recent Advances in Transfer Factor and Dialyzable Leukocyte Extracts; Fujisawa, T.; Sasakawa, S.; Iicura, Y.; Komatu, F.; Yamaguchi, Y., Eds.; Maruzen: Tokyo, 1991; 256-263.
6. Vacek, A.; Hofer, M.; Barnet, K.; Čech, K.; Pekárek J. Positive effects of dialyzable leukocyte extract (DLE) on recovery of mouse haemopoiesis suppressed by ionizing radiation and on proliferation of haemopoietic progenitor cells in vitro. Int. J. Immunopharmac. 2000, 22, 623-634.
7. Vacek, A.; Hofer, M.; Hromas, J.; Lukšíková, E.; Svoboda, J.; Schneiderová, H. Hemopoiesis-stimulating effect and enhanced survival of irradiated mice after peroral or intraperitoneal administration of ultrafiltered pig leukocyte extract (UPLE, IMUNOR). Immunopharmacol. Immunotoxicol. 2002, 24, 651-664.
8. Barnet, K.; Vacek, A.; Čech, K.; Pekárek, J. The effect of DLE fractions on GM-progenitors of haemopoietic stem cells.Biotherapy. 1996, 9, 171-174.
9. Vacek, A.; Barnet, K.; Hofer, M.; Čech, K.; Pekárek, J.; Schneiderová H. Stimulation of hemopoietic colony formation from mouse marrow cells in vitro using human dialyzable leukocyte extracts IMMODIN-SEVAC. Int. J. Immunopharmac. 1997, 19, 431-436.
10. Vacek, A.; Hofer, M.; Schneiderová, H.; Svoboda, J. Ultrafiltered pig leukocyte extract (UPLE, Imunor) potentiates hematopoiesis-stimulating effect og G-CSF in vitro and improves the outcome of treatment of hematopoietic radiation damage in mice with G-CSF. Immunopharmacol. Immunotoxicol. 2005, 27, 647-659.
11. Vacek, A.; Rotkovská, D.; Bartoníčková A. Radioprotection of hemopoiesis conferred by aqueous extract from chlorococcal algae (Ivastimul) administration to mice before irradiation. Exp. Hematol. 1990, 18, 234-237.
12. Karasuyama, H.; Melchers F. Establishment of mouse cell lines which constitutively secrete large quantities of interleukins 2, 3, 4 or 5 using modified cDNA expression vectors. Eur. J. Immunol. 1988, 18, 97-104.
13. Marsh, J.C. The effects of cancer chemotherapeutic agents on normal hematopoietic precursor cells. A review. Cancer Res. 1976, 36, 1853-1882.
14. Rich, I.N. The effect of 5-fluorouracil of erythropoiesis. Blood 1991, 77, 1164-1170.
15. Vrána, O.; Brabec, V.; Kleinwächter, V. Polarographic studies on the conformation of some platinum complexes: relationship to anti-tumour activity. Anti-Cancer Drug Des. 1986, 1, 95-109.
16. Johnson, N.P.; Butour, J.L.; Villani, G.; Wimmer, F.L.; Defais, M.; Pierson, V.; Brabec, V. Metal antitumor compounds: The mechanism of the action of platinum complexes. In Progress in Clinical Biochemistry and Medicine, Vol. 10; Springer-Verlag: Berlin, Heidelberg, 1989; 2-24.
17. Brabec, V. DNA modifications by novel antitumor platinum drugs. In Frontiers of Multifunctional Nanosystems; Buzaneva, E.; Scharff, P., Eds.; Kluver: Amsterdam, 2002; 229-250.
18. Peng, R.; Wang, D.; Xiong, C.; Gao, Y.; Li, Y.; Yang, H.; Cui Y. Interleukin-3 gene expression in irradiated mouse bone marrow. J. Environ. Pathol. Toxicol. Oncol. 1988, 17, 135-142.
19. Xu, S.Y.; Hoglund, M.; Hakansson, L.; Venge, P. Granulocyte colony-stimulating factor (G-CSF) induces the production of cytokines in vivo. Br. J. Haematol. 2000, 108, 848-853.
20. Kadar, E.; Sureda, A.; Mangues, M.A.; Ingles-Esteve, J.; Valls, A.; Garcia, J. Serum levels of G-CSF, IL-3, IL-6 and GM-CSF after a single intraperitoneal dose of rhG-CSF in lethally irradiated B6D2F1 mice. Acta Haematol. 1997, 98, 119-124.
21. Fedoročko, P.; Egyed, A.; Vacek, A. Irradiation induces increased production of haemopoietic and proinflamatory cytokines in the mouse lung. Int. J. Rad. Biol. 2002, 78, 305-313.