N-boc protection of amines with di-tert-butyldicarbonate in water under neutral conditions in the presence of β-cyclodextrin

Synlett

Volumn , Issue 7, 2006, Pages 1110-1112

  Somi Reddy, M ^a   Narender, M ^a   Nageswar, Y V D ^a   Rama Rao, K ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

cyclodextrin; Amines; Boc anhydride; Boc derivatives; Water

Indexed keywords

AMINE; BETA CYCLODEXTRIN; BICARBONATE; CARBONYL DERIVATIVE; TERT BUTOXY CARBONYL; UNCLASSIFIED DRUG; WATER;

ARTICLE; CATALYST; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; ELECTRON; ROOM TEMPERATURE;

EID: 33646587046     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-939689     Document Type: Article

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26. 4), filtered and the solvent was removed under vacuum. The crude product was purified by silica gel column chromatography with EtOAc-hexane (1:9) as eluent. β-Cyclodextrin was recovered (95%) after lyophilization of the aqueous phase.