Glycoprotein Ibα-mediated platelet adhesion and aggregation to immobilized thrombin under conditions of flow

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 26, Issue 3, 2006, Pages 670-675

  Weeterings, Cees ^a,b   Adelmeijer, Jelle ^a   Myles, Timothy ^c   De Groot, Philip G ^a,b   Lisman, Ton ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fibrin; Flow conditions; GPIb ; Platelet; Thrombin

Indexed keywords

DEXTRO ARGINYLGLYCYLASPARTYLTRYPTOPHAN; FIBRIN; GLYCOCALICIN; GLYCOPROTEIN IB ALPHA; PEPTIDE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; UNCLASSIFIED DRUG; THROMBIN RECEPTOR;

ARTICLE; BLOOD FLOW; CELL SECRETION; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; PROTEIN INTERACTION; RECEPTOR UPREGULATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE KINETICS; HEMOSTASIS; IN VITRO STUDY; MECHANICAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SCANNING ELECTRON MICROSCOPY; THROMBOCYTE; THROMBOCYTE ADHESIVENESS; THROMBOSIS; ULTRASTRUCTURE;

BLOOD PLATELETS; FIBRIN; HEMOSTASIS; HUMANS; MICROSCOPY, ELECTRON, SCANNING; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; REGIONAL BLOOD FLOW; STRESS, MECHANICAL; THROMBIN; THROMBOSIS;

EID: 33646582680     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000200391.70818.a9     Document Type: Article

References (27)

1. Nilsen DW, Brosstad F, Kierulf P, Godal HC. Binding of various thrombin fractions to fibrin and the influence of AT-III on their adsorption. Thromb Haemost. 1986;55:352-356.
2. Weitz JI, Hudoba M, Massel D, Maraganore J, Hirsh J. Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. J Clin Invest. 1990;86:385-391.
3. Becker DL, Fredenburgh JC, Stafford AR, Weitz JI. Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II. J Biol Chem. 1999;274:6226-6233.
4. dem Borne PA, Meijers JC, Bouma BN. Effect of heparin on the activation of factor XI by fibrin-bound thrombin. Thromb Haemost. 1996;76:347-353.
5. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999;103:879-887.
6. Okumura T, Hasitz M, Jamieson GA. Platelet glycocalicin. Interaction with thrombin and role as thrombin receptor of the platelet surface. J Biol Chem. 1978;253:3435-3443.
7. Harmon JT, Jamieson GA. The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with platelets. J Biol Chem. 1986;261:13224-13229.
8. De Marco L, Mazzucato M, Masotti A, Fenton JW, Ruggeri ZM. Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin. J Biol Chem. 1991;266:23776-23783.
9. Shrimpton CN, Borthakur G, Larrucea S, Cruz MA, Dong JF, Lopez JA. Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. J Exp Med. 2002;196:1057-1066.
10. Vanhoorelbeke K, Ulrichts H, Romijn RA, Huizinga EG, Deckmyn H. The GPIbalpha-thrombin interaction: far from crystal clear. Trends Mol Med. 2004;10:33-39.
11. Hall SW, Gibbs CS, Leung LL. Identification of critical residues on thrombin mediating its interaction with fibrin. Thromb Haemost. 2001; 86:1466-1474.
12. Myles T, Le Bonniec BF, Stone SR. The dual role of thrombin's anion-binding exosite-I in the recognition and cleavage of the protease-activated receptor 1. Eur J Biochem. 2001;268:70-77.
13. Sheehan JP, Sadler JE. Molecular mapping of the heparin-binding exosite of thrombin. Proc Natl Acad Sci U S A. 1994;91:5518-5522.
14. Di Cera E. Thrombin interactions. Chest. 2003;124:11S-17S.
15. Li CQ, Vindigni A, Sadler JE, Wardell MR. Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin. J Biol Chem. 2001;276:6161-6168.
16. De Cristofaro R, De Candia E, Landolfi R, Rutella S, Hall SW. Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib. Biochemistry. 2001;40:13268-13273.
17. Celikel R, McClintock RA, Roberts JR, Mendolicchio GL, Ware J, Varughese KI, Ruggeri ZM. Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha. Science. 2003; 301:218-221.
18. Dumas JJ, Kumar R, Seehra J, Somers WS, Mosyak L. Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation. Science. 2003;301:222-226.
19. Sadler JE. Structural biology. A menage a trois in two configurations. Science. 2003;301:177-179.
20. Adam F, Guillin MC, Jandrot-Perrus M. Glycoprotein Ib-mediated platelet activation. A signalling pathway triggered by thrombin. Eur J Biochem. 2003;270:2959-2970.
21. Savage B, Saldivar E, Ruggeri ZM. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell. 1996;84:289-297.
22. Yun TH, Baglia FA, Myles T, Navaneetham D, Lopez JA, Walsh PN, Leung LL. Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively. J Biol Chem. 2003;278:48112-48119.
23. Hantgan RR, Hindriks G, Taylor RG, Sixma JJ, de Groot PG. Glycoprotein Ib, von Willebrand factor, and glycoprotein IIb:IIIa are all involved in platelet adhesion to fibrin in flowing whole blood. Blood. 1990;76:345-353.
24. Englund GD, Bodnar RJ, Li Z, Ruggeri ZM, Du X. Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signal. J Biol Chem. 2001;276: 16952-16959.
25. Huntington JA. Molecular recognition mechanisms of thrombin. J Thromb Haemost. 2005;3:1861-1872.
26. Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost. 2005;3:1894-1904.
27. Lane DA, Philippou H, Huntington JA. Directing thrombin. Blood. 2005; 106:2605-2612.