Ameloblastin fusion protein enhances pulpal healing and dentin formation in porcine teeth

Calcified Tissue International

Volumn 78, Issue 5, 2006, Pages 278-284

  Nakamura, Y ^a   Slaby, I ^b   Spahr, A ^c   Pezeshki, G ^c   Matsumoto, K ^a   Lyngstadaas, S P ^d  

^a SHOWA UNIVERSITY   (Japan)

^b A Company of the Straumann Group   (Sweden)

^c UNIVERSITY OF ULM   (Germany)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

Amelin; Ameloblastin; Dental pulp healing; Dentinogenesis; Pulpotomy

Indexed keywords

AMELIN; AMELOBLASTIN; CALCIUM HYDROXIDE; COLLAGEN TYPE 1; ENAMEL PROTEIN; HYBRID PROTEIN; SHEATHLIN; SIALOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTIN; ECTODERM; ENDODONTICS; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INCISOR; INFLAMMATORY INFILTRATE; MESENCHYME; MINIPIG; MORPHOMETRICS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TOOTH DEVELOPMENT; TOOTH PULP; WESTERN BLOTTING; WOUND HEALING;

ANIMALS; DENTAL ENAMEL PROTEINS; DENTAL PULP; DENTAL PULP DISEASES; DENTIN; DENTINOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; REGENERATION; SUS SCROFA; TOOTH INJURIES; TREATMENT OUTCOME; WOUND HEALING;

EID: 33646576231     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-005-0144-2     Document Type: Article

References (23)

1. Yamamura T (1985) Differentiation of pulpal cells and inductive influences of various matrices with reference to pulpal wound healing. J Dent Res 64:530-540
2. Ranly DM (1994) Pulpotomy therapy in primary teeth: new modalities for old rationales. Pediatr Dent 16:403-409
3. Ranly DM, Garcia-Godoy F (2000) Current and potential pulp therapies for primary and young permanent teeth. J Dent 28:153-161
4. Tziafas D, Smith AJ, Lesot H (2000) Designing new treatment strategies in vital pulp therapy. J Dent 28:77-92
5. Nakashima M (1994) Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and -4. J Dent Res 73:1515-1522
6. Rutherford RB, Wahle J, Tucker M, Rueger D, Charette M (1993) Induction of reparative dentin formation in monkeys by recombinant human osteogenic protein-1. Arch Oral Biol 38:571-576
7. Nakashima M (1989) Dentin induction by implants of autolyzed antigen-extracted allogeneic dentin on amputated pulps of dogs. Endod Dent Traumatol 5:279-286
8. Termine JD, Belcourt AB, Christner PJ, Conn KM, Nylen MU (1980) Properties of dissociatively extracted fetal tooth matrix proteins. I. Principal molecular species in developing bovine enamel. J Biol Chem 255:9760-9768
9. Nakamura Y, Hammarström L, Lundberg E, Ekdahl H, Matsumoto K, Gestrelius S, Lyngstadaas SP (2001) Enamel matrix derivative promotes reparative processes in the dental pulp. Adv Dent Res 15:105-107
10. Nakamura Y, Hammarström L, Matsumoto K, Lyngstadaas SP (2002) The induction of reparative dentin by enamel proteins. Int Endod J 35:407-417
11. Nakamura Y, Slaby I, Matsumoto K, Richie HH, Lyngstadaas SP (2004) Immunohistochemical characterization of rapid dentin formation induced by enamel matrix derivative. Calcif Tissue Int 75:243-252
12. Cerny R, Slaby I, Hammarström L, Wurtz T (1996) A novel gene expressed in rat ameloblasts codes for proteins with cell binding domains. J Bone Miner Res 11:883-891
13. Krebsbach PH, Lee SK, Matsuki Y, Kozak CA, Yamada KM, Yamada Y (1996) Full-length sequence, localization, and chromosomal mapping of ameloblastin. A novel tooth-specific gene. J Biol Chem 271:4431-4435
14. Hu CC, Fukae M, Uchida T, Qian Q, Zhang CH, Ryu OH, Tanabe T, Yamakoshi Y, Murakami C, Dohi N, Shimizu M, Simmer JP (1997) Sheathlin: cloning, cDNA/ polypeptide sequences, and immunolocalization of porcine enamel sheath proteins. J Dent Res 76:648-657
15. MacDougall M, Simmons D, Gu TT, Forsman-Semb K, Mardh CK, Mesbah M, Forest N, Krebsbach PH, Yamada Y, Berdal A (2000) Cloning, characterization and immunolocalization of human ameloblastin. Eur J Oral Sci 108:303-310
16. Uchida T, Murakami C, Wakida K, Dohi N, Iwai Y, Simmer JP, Fukae M, Satoda T, Takahashi O (1998) Sheath proteins: synthesis, secretion, degradation and fate in forming enamel. Eur J Oral Sci 106(suppl 1):308-314
17. Fong CD, Slaby I, Hammarström L (1996) Amelin: an enamel-related protein, transcribed in the cells of epithelial root sheath. J Bone Miner Res 11:892-898
18. Fong CD, Cerny R, Hammarstöm L, Slaby I (1998) Sequential expression of amelin gene in mesenchymal and epithelial cells during odontogenesis in rats. Eur J Oral Sci 106(Suppl 1):324-330
19. Spahr A, Lyngstadaas SP, Slaby I, Haller B, Boeckh C, Tsoulfidou F, Hammarstrom L (2002) Expression of amelin and trauma-induced dentin formation. Clin Oral Investig 6:51-57
20. Ritchie H, Wang L-H (1998) The expression of DSP protein from a baculovirus construct containing rat DSP-PP cDNA. J Dent Res 77:157
21. Van Ittersum J, Ritchie H (2002) Post-translational analysis of rat dentin phosphophoryn from dentin matrix and a DSP-PP construct. J Dent Res 81:A278
22. Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577-580
23. Butler WT (1995) Dentin matrix proteins and dentinogenesis. Connect Tissue Res 33:59-65