Effects of different phytosterol analogs on colonic mucosal cell proliferation in hamsters

Journal of Nutritional Biochemistry

Volumn 17, Issue 6, 2006, Pages 396-401

  Jia, Xiaoming ^a   Ebine, Naoyuki ^a   Wang, Yanwen ^b   Awad, Atif B ^c   Jones, Peter J H ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Ascorbic acid; Colon cell proliferation; Ki 67; n 3 Polyunsaturated fatty acid; Plant stanols; Plant sterols; Stanol esters; Sterol esters

Indexed keywords

ASCORBIC ACID; CHOLESTEROL ESTERASE; MONOCLONAL ANTIBODY KI 67; PHYTOSTEROL; STANOL ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; CHOLESTEROL DIET; COLON MUCOSA; CONTROLLED STUDY; DIETARY INTAKE; FOOD COMPOSITION; HAMSTER; IMMUNOHISTOCHEMISTRY; MALE; MUCOSA CELL; NONHUMAN;

ANIMALS; ANTICARCINOGENIC AGENTS; ASCORBIC ACID; BODY WEIGHT; CELL DIVISION; CHOLESTEROL, DIETARY; COLON; CRICETINAE; EATING; ESTERIFICATION; INTESTINAL MUCOSA; MALE; MESOCRICETUS; PHYTOSTEROLS;

CRICETINAE;

EID: 33646559572     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2005.08.013     Document Type: Article

References (35)

1. Pollack O.J. Reduction of blood cholesterol in man. Circulation 7 (1953) 702-706
2. Pollack O.J., and Kritchevsk D. Sitosterol. Monogr Atheroscler 10 (1981) 1-219
3. Jones P.J.H., Ntanios F.Y., Raeini-Sarjaz M., and Vanstone C.A. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am J Clin Nutr 69 (1999) 1140-1150
4. Hallikainen M.A., Sarkkinen E.S., and Gylling H. Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet. Eur J Clin Nutr 54 (2000) 715-725
5. Vanstone C.A., Raeini-Sarjaz M., Parsons W.E., and Jones P.J. Unesteried plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons. Am J Clin Nutr 76 (2002) 1272-1278
6. Skeaff C.M., Thoma C., Chisholm A., Mann J., and Williams S. Effects on plasma lipids when plant sterol enriched fat spread or carbohydrate provide replacement energy for saturated fatty acids. Asia Pac J Clin Nutr 13 (2004) 80-87
7. Thomsen A.B., Hansen H.B., Christiansen C., Green H., and Berger A. Effect of free plant sterols in low-fat milk on serum lipid profile in hypercholesterolemic subjects. Eur J Clin Nutr 58 (2004) 860-870
8. Raicht R.F., Cohen L.I., Fazzini E.P., Sarwal A.N., and Takahashi M. Protective effect of plant sterols against chemically induced colon tumors in rats. Cancer Res 40 (1980) 403-405
9. Awad A.B., Chen Y.C., Fink C.S., and Hennessey T. β-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids. Anticancer Res 16 (1996) 2797-2804
10. Awad A.B., Hernandez A.Y.T., Fink C.S., and Mendel S.L. Effect of dietary phytosterols on cell proliferation and protein kinase C activity in rat colonic mucosa. Nutr Cancer 27 (1997) 210-215
11. Lipkin M., Uehara K., Winawer S., Blattner W.A., and Fraumeni J. Seventh-day Adventist vegetarians have a quiescent proliferative activity in colonic mucosa. Cancer Lett 26 (1985) 139-144
12. Conklin K.A. Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects. Nutr Cancer 37 (2000) 1-18
13. Pathak A.K., Singh N., Khanna N., Reddy V.G., Prasad K.N., and Kochupillai V. Potentiation of the effect of paclitaxel and carboplatin by antioxidant mixture on human lung cancer H520 cells. J Am Coll Nutr 21 (2002) 416-421
14. Blot W.J., Lanier A., Fraumeni J.F., and Bender T.R. Cancer mortality among Alaskan natives, 1960-1969. J Natl Cancer Inst 55 (1975) 547-554
15. Bang H.O., Dyerberg J., and Hjoorne N. The composition of food consumed by Greenland Eskimos. Acta Med Scand 200 (1976) 69-73
16. Schloss I., Kidd M.S., Tichelaar H.Y., Young G.O., and O'Keefe S.J. Dietary factors associated with a low risk of colon cancer in coloured west coast fishermen. S Afr Med J 87 (1997) 152-158
17. Caygill C.P., Charlett A., and Hill M.J. Fat, fish, fish oil and cancer. Br J Cancer 74 (1996) 159-164
18. Bartsch H., Nair J., and Owen R.W. Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 20 (1999) 2209-2218
19. Minoura T., Takata T., Sakaguchi M., Takada H., Yamamura M., Hioki K., et al. Effect of dietary eicosapentaenoic acid on azoxymethane-induced colon carcinogenesis in rats. Cancer Res 48 (1988) 4790-4794
20. Calviello G., Palozza P., Maggiano N., Piccioni E., Franceschelli P., Frattucci A., et al. Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa. Lipids 34 (1999) 599-604
21. Rose D.P., and Connolly J.M. Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther 83 (1999) 217-244
22. Boudreau M.C., Sohn K.H., Rhee S.H., Lee S.W., Hunt J.D., and Hwang D.H. Suppression of tumor cell growth both in nude mice and in culture by n-3 polyunsaturated fatty acids: mediation through cyclooxygenase-independent pathways. Cancer Res 61 (2001) 1386-1391
23. SAS Institute. SAS user's guide: statistics, version 6.12 (1994), SAS Institute, Cary, NC
24. Chang W.L., Chapkin R.S., and Lupton J.R. Fish oil blocks azoxymethane-induced rat colon tumorigenesis by increasing cell differentiation and apoptosis rather than decreasing cell proliferation. J Nutr 128 (1998) 491-497
25. Latham P., Lund E.K., and Johnson I.T. Dietary n-3 PUFA increases the apoptotic response to 1,2-dimethyldrazine, reduces mitosis and suppresses the induction of carcinogenesis in the rat colon. Carcinogenesis 20 (1999) 645-650
26. Janezic S.A., and Rao A.V. Dose-dependent effect of dietary phytosterols on epithelial cell proliferation of the murine colon. Food Chem Toxicol 30 (1992) 611-616
27. Frei B. Ascorbic acid protects lipids in human and low-density lipoprotein against oxidative damage. Am J Clin Nutr 54 (1991) 1113S-1118S
28. Taper H.S., Gerlache J., Lans M., and Roberfroid M. Non-toxic potentiation of cancer chemotherapy by combined C and K vitamin pre-treatment. Int J Cancer 40 (1987) 575-579
29. Shimpo K., Nagatsu T., Yamada K., Sato T., and Fujita K. Ascorbic acid and adriamycin toxicity. Am J Clin Nutr 54 (1991) 1298S-1301S
30. Crott J.W., and Fenech M. Effect of vitamin C supplementation on chromosome damage, apoptosis and necrosis ex vivo. Carcinogenesis 20 (1999) 1035-1041
31. Chen K., Suh J., Carr A.C., Morrow J.D., Zeind J., and Frei B. Vitamin C suppresses oxidative lipid damage in vivo, even in the presence of iron overload. Am J Physiol Endocrinol Metab 279 (2000) E1406-E1412
32. Proteggente A.R., Rehman A., Halliwell B., and Rice-Evans C.A. Potential problems of ascorbate and iron supplementation: pro-oxidant effect in vivo?. Biophys Res Commun 277 (2000) 535-540
33. Suh J., Zhu B.Z., and Frei B. Ascorbate does not act as a pro-oxidant towards lipids and proteins in human plasma exposed to redox-active transition metal ions and hydrogen peroxide. Free Radic Biol Med 34 (2003) 1306-1314
34. Ashidate K., Kawamura M., Tohda H., Miyazaki S., Hayashi H., Teramoto T., et al. Ascorbic acid augments cytotoxicity induced by oxidized low-density lipoprotein. J Atheroscler Thromb 10 (2003) 7-12
35. Horton J.D., Cuthbert J.A., and Spady D.K. Regulation of hepatic 7α-hydroxylase expression and response to dietary cholesterol in the rat and hamster. J Biol Chem 270 (1995) 5381-5387