Transplantation of cultured progenitor cells to the mammalian retina

Expert Opinion on Biological Therapy

Volumn 6, Issue 5, 2006, Pages 443-451

  Klassen, Henry ^a  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

Author keywords

Biodegradable polymers; Immune privilege; Neural stem cells; Regenerative medicine; Retinal degeneration; Tissue engineering

Indexed keywords

POLYMER; RHODOPSIN;

BIODEGRADABLE IMPLANT; CELL CULTURE; CENTRAL NERVOUS SYSTEM; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE TREATMENT; MAJOR HISTOCOMPATIBILITY COMPLEX; MAMMAL; MICROENVIRONMENT; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; RETINA; RETINA NEUROEPITHELIAL LAYER; REVIEW; STEM CELL TRANSPLANTATION; SWINE;

ABSORBABLE IMPLANTS; ANIMALS; CELL DIFFERENTIATION; CELL MOVEMENT; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; MODELS, ANIMAL; MULTIPOTENT STEM CELLS; POLYMERS; RETINA; RETINAL DEGENERATION; RHODOPSIN; STEM CELL TRANSPLANTATION; SWINE; TRANSPLANTATION, HETEROLOGOUS;

MAMMALIA; RODENTIA; SUS SCROFA;

EID: 33646537505     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.6.5.443     Document Type: Review

References (33)

1. WENKEL H, CHEN PW, KSANDER BR, STREILEIN JW: Immune privilege is extended, then withdrawn, from allogeneic tumor cell grafts placed in the subretinal space. Invest. Ophthalmol. Vis. Sci. (1999) 40:3202-3208.
2. SILVERMAN MS, HUGHES SE: Transplantation of photoreceptots to light-damaged retina. Invest. Ophthalmol. Vis. Sci. (1989) 30:1684-1690.
3. LI LX, TURNER JE: Inherited retinal dystrophy in the RCS rat: prevention of photoreceptor degeneration by pigment epithelial cell transplantation. Exp. Eye Res. (1988) 47:911-917.
4. LOPEZ R, GOURAS P, KJELDBYE H et al.: Transplanted retinal pigment epithelium modifies the retinal degeneration in the RCS rat. Invest. Ophthalmol. Vis. Sci. (1989) 30:586-588.
5. BERSON EL, JAKOBIEC FA: Neural retinal cell transplantation: ideal versus reality. Ophthalmology (1999) 106:445-446
6. ZHANG Y, KARDASZEWSKA AK, VAN VEEN T, RAUCH U, PEREZ MT: Integration between abutting retinas: role of glial structures and associated molecules at the interface. Invest. Ophthalmol. Vis. Sci. (2004) 45:4440-4449.
7. SILVER J, MILLER JH: Regeneration beyond the glial scar. Nat. Rev. Neurosci. (2004) 5:146-156.
8. DAVID S, LACROIX S: Molecular approaches to spinal cord repair. Annu. Rev. Neurosci. (2003) 26:411-440.
9. YOUNG MJ, RAY J, WHITELEY SJ, KLASSEN H, GAGE FH: Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystropic rats. Mol. Cell. Neurosci. (2000) 16:1997-2005.
10. KLASSEN HJ, NG TF, KURIMOTO Y et al.: Multipotent progenitor cells from the retina express developmental markers, differentiate into neurons, and preserve visually mediated behavior. Invest. Ophthalmol. Vis. Sci. (2004) 45:4167-4173.
11. TAKAHASHI M, PALMER TD, TAKAHASHI J, GAGE FH: Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol. Cell. Neurosci. (1998) 12:340-348.
12. VAN HOFFELEN SJ, YOUNG MJ, SHATOS MA, SAKAGUCHI, DS: Incorporation of murine brain progenitor cells into the developing mammalian retina. Invest. Ophthalmol. Vis. Sci. (2003) 44:426-434.
13. GLEESON JG, LIN PT, FLANAGAN LA, WALSH CA: Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron (1999) 23:257-271.
14. ZAHIR T, KLASSEN H, YOUNG MJ: Effects of ciliary neurotrophic factor on differentiation of late retinal progenitor cells. Stem Cells (2005) 23:424-432.
15. KLASSEN H, IMFELD K, RAY J, YOUNG MJ, GAGE FH, BERMAN M: The immunological properties of adult hippocampal progenitor cells. Vision Res. (2003) 43:947-956.
16. HORI J, NG TF, SHATOS M, KLASSEN H, STREILEIN JW, YOUNG MJ: Neural stem cells lack immunogenicity and resist destruction as allografts. Stem Cells (2003) 21:405-416.
17. KLASSEN H, SCHWARTZ M, BAILEY A, YOUNG MJ: Surface markers expressed by multipotent human and mouse neural progenitor cells include tetraspanins and non-protein epitopes. Neurosci. Lett. (2001) 312:180-182.
18. SCHWARTZ PH, BRYANT PJ, FUJA TJ, SU H, O'DOWD DK, KLASSEN H: Isolation and characterization of neural progenitor cells from post-mortem human cortex. J. Neurosci. Res. (2003) 74:838-851.
19. KLASSEN H, ZIAEIAN B, KIROV II, YOUNG MJ, SCHWARTZ PH: Isolation of retinal progenitor cells from postmortem human tissue with comparison to autologous brain progenitors. J. Neurosci. Res. (2004) 77:334-343.
20. AHMAD I, DOOLEY CM, THORESON WB, ROGERS JA, AFIAT S: In vitro analysis of a mammalian retinal progenitor that gives rise to neurons and glia. Brain Res. (1999) 831:1-10.
21. YANG P, SEILER MJ, ARAMANT RB, WHITTEMORE SR: Differential lineage restriction of rat retinal progenitor cells in vitro and in vivo. J. Neurosci. Res. (2002) 69:466-476.
22. SCHWARTZ PH, NETHERCOTT H, KIROV II, ZIAEIAN B, YOUNG MJ, KLASSEN H: Expression of neurodevelopmental markers by cultured porcine neural precursor cells. Stem Cells (2005) 23:1286-1294.
23. HUH GS, BOULANGER LM, DU H, RIQUELME PA, BROTZ TM, SHATZ CJ: Functional requirement for class I MHC in CNS development and plasticity. Science (2000) 290:2155-2159.
24. KLASSEN HJ, IMFELD KL, KIROV IL et al.: Expression of cytokines by multipotent neural progenitor cells. Cytokine (2003) 22:101-106.
25. OSAWA H, MARUYAMA K, STREILEIN JW: CD95 ligand expression on corneal epithelium and endothelium influences the fates of orthotopic and heterotopic corneal allografts in mice. Invest. Ophthalmol. Vis. Sci. (2004) 45:1908-1915.
26. KWIDZINSKI E, BUNSE J, KOVAC AD et al.: Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation. FASEB J. (2005) 19:1347-1349.
27. LAVIK EB, KLASSEN H, WARFVINGE K, LANGER R, YOUNG MJ: Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitors. Biomaterials (2005) 26:3187-3196.
28. TOMITA M, LAVIK E, KLASSEN H, ZAHIR T, LANGER R, YOUNG MJ: Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells. Stem Cells (2005) 23:1579-1588.
29. WARFVINGE K, KIILGAARD JF, LAVIK EB et al.: Retinal progenitor cell xenografts to the pig retina: morphological integration and cytochemical differentiation. Arch. Ophthalmol. (2005) 123:1385-1393.
30. YOUNG MJ, RAO K, LUND RD: Integrity of the blood-brain barrier in retinal xenografts is correlated with the immunological status of the host. J. Comp. Neurol. (1989) 283:107-117.
31. SMITH PM, BLAKEMORE WF: Porcine neural progenitors require commitment to the oligodendrocyte lineage prior to transplantation in order to achieve significant remyelination of demyelinated lesions in the adult CNS. Eur. J. Neurosci. (2000) 12:2414-2424.
32. ARMSTRONG RJ, HARROWER TP, HURELBRINK CB et al.: Porcine neural xenografts in the immunocompetent rat: immune response following grafting of expanded neural precursor cells. Neuroscience (2001) 106:201-216.
33. UCHIDA K, OKANO H, HAYASHI T et al.: Grafted swine neuroepithelial stem cells can form myelinated axons and both efferent and afferent synapses with xenogeneic rat neurons. J. Neurosci. Res. (2003) 72:61-69.