Morphine-induced reduction of intraocular pressure and pupil diameter: Role of nitric oxide

Pharmacology

Volumn 77, Issue 1, 2006, Pages 17-24

  Dortch Carnes, Juanita ^a   Russell, Karen R M ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

Intraocular pressure; Morphine; Nitric oxide; Opioid receptors ( 3); Pupil diameter

Indexed keywords

GLUTATHIONE; MORPHINE; MU OPIATE RECEPTOR; MU3 OPIATE RECEPTOR; N(G) NITROARGININE METHYL ESTER; NALOXONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OPIATE ANTAGONIST; RECEPTOR SUBTYPE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; INTRAOCULAR HYPOTENSION; MIOSIS; NONHUMAN; PNEUMOTONOMETER; PRIORITY JOURNAL; RABBIT; RECEPTOR DOWN REGULATION; TONOMETER;

ANIMALS; DARK ADAPTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUTATHIONE; INTRAOCULAR PRESSURE; MIOSIS; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OCULAR HYPOTENSION; PUPIL; RABBITS; RECEPTORS, OPIOID, MU;

EID: 33646501940     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000091993     Document Type: Article

References (38)

1. Miyashita H: Ocular tension. Zentralbl Biochem Biophysik 1913;15:95-98.
2. Leopold IH, Comroe JH: Effect of intramuscular administration of morphine, atropine, scopolamine and neostigmine on the human eye. Arch Ophthalmol 1948;40:285-291.
3. Fanciullacci M, Boccuni M, Pietrini U, Sicuteri F: The naloxone conjunctival test in morphine addiction. Eur J Pharmacol 1980;61:319-320.
4. Drago F, Panissidi G, Bellomio F, Dal Bello A, Aguglia E, Gorgone G: Effects of opiates and opioids on intraocular pressure of rabbits and humans. Clin Exp Pharmacol Physiol 1985;12:107-113.
5. Murray RB, Adler MW, Korczyn AD: The pupillary effects of opioids. Life Sci 1983;33:495-509.
6. Lee HK, Wang SC: Mechanism of morphine-induced miosis in the dog. J Pharmacol Exp Ther 1975;192:415-431.
7. Fanciullacci M, Boccuni M, Pietrini U, Sicuteri F: Search for opiate receptors in human pupil. Int J Clin Pharmacol Res 1980;1:109-113.
8. Drago F, Gorgone G, Spina F, Panissidi G, Dal Bello A, Moro F, Scapaginini U: Opiate receptors in the rabbit iris. Naunyn Schmiedebergs Arch Pharmacol 1980;315:1-4.
9. Stone RA, Kuwayama Y, Laties AM: Regulatory peptides in the eye. Experientia 1987;43:791-800.
10. Lord JA, Waterfield AA, Hughes J, Kosterlitz HW: Endogenous opioid peptides: multiple agonists and receptors. Nature 1977;267:495.
11. Pasternak GW: Multiple mu opiate receptors: biochemical and pharmacological evidence for multiplicity. Biochem Pharmacol 1986;35:361-364.
12. Wolozin BI, Pasternak GW: Classification of multiple morphine and enkephalin binding sites in the central nervous system Proc Natl Acad Sci USA 1986;78:6181-6185.
13. Lutz RA, Cruciani RA, Costa T, Munson PJ, Rodbard D: A very high affinity opioid binding site in rat brain: demonstration by computer modeling. Biochem Biophys Res Commun 1984;122:265-269.
14. Stefano GB, Digenis A, Spector S, Leung MK, Bilfinger TV, Makman MH, Scharrer B, Abumrad NN: Opiate-like substances in an invertebrate, an opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression. Proc Natl Acad Sci USA 1993;90:11099-11103.
15. Rowland JM, Potter DE, Reiter RJ: Circadian rhythm in intraocular pressure: a rabbit model. Curr Eye Res 1981;1:169-173.
16. Bar-Ilan A: Diurnal and seasonal variations in intraocular pressure in the rabbit. Exp Eye Res 1984;39:175-181.
17. Rowland JM, Sawyer WK, Tittel J, Ford CJ: Studies on the circadian rhythm of IOP in rabbits: correlation with aqueous inflow and cAMP content. Curr Eye Res 1986;5:201-206.
18. Smith SD, Gregory DA: Circadian rhythm of aqueous flow underlies the circadian rhythm of IOP in NZW rabbits. Invest Ophthalmol Vis Sci 1989;30:775-778.
19. Feelisch M, Noack EA: Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. Eur J Pharmacol 1987;139:19-30.
20. Murad F: Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone? Recent Prog Horm Res 1998;53:43-60.
21. Wang Y, Vodovotz Y, Kim PK, Zamora R, Billiar TR: Mechanisms of hepatoprotection by nitric oxide. Ann N Y Acad Sci 2002;962:415-422.
22. Kroncke KD, Fehsel K, Kolb-Bachofen V: Nitric oxide: cytotoxicity versus cytoprotection - how, why, when, and where? Nitric Oxide 1997;1:107-120.
23. Chiou GC: Review: effects of nitric oxide on eye diseases and their treatment. J Ocul Pharmacol Ther 2001;17:189-198.
24. Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, Befort K, Dierich A, LeMeur M, Dolle P, Tzavara E, Hanoune J, Roques BP, Kieffer BL: Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 1996;383:819-823.
25. Stefano GB: The μ3 opiate receptor subtype. Pain Forum 1999;8:206-209.
26. Makman MH, Dobrenis K, Downie S, Lyman WD, Dvorkin B: Presence of opiate alkaloid-selective mu3 receptors in cultured astrocytes and in brain and retina. Adv Exp Med Biol 1996;402:23-28.
27. Stefano GB, Scharrer B, Smith EM, Hughes TK Jr, Magazine HI, Bilfinger TV, Hartman AR, Fricchione GL, Liu Y, Makman MH: Opioid and opiate immunoregulatory processes. Crit Rev Immunol 1996;16:109-144.
28. Prevot V, Rialas CM, Croix D, Salzet M, Dupouy JP, Poulain P, Beauvillain JC, Stefano GB: Morphine and anandamide coupling to nitric oxide stimulates GnRH and CRF release from rat median eminence: neurovascular regulation. Brain Res 1998;790:236-244.
29. Stefano GB, Zhu W, Cadet P, Bilfinger TV, Mantione K: Morphine enhances nitric oxide release in the mammalian gastrointestinal tract via the μ3 opiate receptor subtype: a hormonal role for endogenous morphine. J Physiol Pharmacol 2004;55:279-288.
30. Nathanson JA: Nitrovasodilators as a new class of ocular hypotensive agents. J Pharmacol Exp Ther 1992;260:956-965.
31. Behar-Cohen FF, Goureau O, D'Hermies F, Courtois Y: Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye. Invest Ophthalmol Vis Sci 1996;37:1711-1715.
32. Kotikoski H, Vapaatalo H, Oksala O: Nitric oxide and cyclic GMP enhance aqueous humor outflow facility in rabbits. Curr Eye Res 2003;26:119-123.
33. Larsson LI, Maus T, Brubaker RF, Nathanson JA: Topically applied hydralazine: effects on systemic cardiovascular parameters, blood-aqueous barrier, and aqueous humor dynamics in normotensive humans. J Ocul Pharmacol Ther 1995;11:145-156.
34. Krupin T, Weiss A, Becker B, Holmberg N, Fritz C: Increased intraocular pressure following topical azide or nitroprusside. Invest Ophthalmol Vis Sci 1977;16:1002-1007.
35. Taniguchi T, Kawakami H, Sawada A, Iwaki M, Tsuji A, Sugiyama K, Kitazawa Y: Effects of nitric oxide synthase inhibitor on intraocular pressure and ocular inflammation following laser irradiation in rabbits. Curr Eye Res 1998;17:308-315.
36. Kiss B, Dallinger S, Findl O, Rainer G, Eichler HG, Schmetterer L: Acetazolamide-induced cerebral and ocular vasodilation in humans is independent of nitric oxide. Am J Physiol 1999;276(6 Pt 2):R1661-R1667.
37. Kiel JW, Reitsamer HA, Walker JS, Kiel FW: Effects of nitric oxide synthase inhibition on ciliary blood flow, aqueous production and intraocular pressure. Exp Eye Res 2001;73:355-364.
38. Kotikoski H, Oksala O, Vapaatalo H, Aine E: Aqueous humor flow after a single oral dose of isosorbide-5-mononitrate in healthy volunteers. Acta Ophthalmol Scand 2003;81:355-360.