The two thrombospondin type I repeat domains of HB-GAM display a cooperative function in N-syndecan binding and regulation of synaptic plasticity

TheScientificWorldJournal

Volumn 6, Issue , 2006, Pages 406-409

  Raulo, Erkki ^a   Tumova, Sarka ^a   Pavlov, Ivan ^b   Hienola, Anni ^a   Lauri, Sari ^a   Taira, Tomi ^a   Rauvala, Heikki ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Brain plasticity; HB GAM; Syndecan; TSR

Indexed keywords

HEMOGLOBIN GAMMA CHAIN; SYNDECAN 3; THROMBOSPONDIN 1;

ARTICLE; HUMAN; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE;

ANIMALS; CARRIER PROTEINS; CYTOKINES; HIPPOCAMPUS; LONG-TERM POTENTIATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; NEURITES; PROTEIN STRUCTURE, TERTIARY; PROTEOGLYCANS; REPETITIVE SEQUENCES, AMINO ACID; SYNDECAN-3; THROMBOSPONDINS;

EID: 33646495963     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2006.80     Document Type: Article

References (16)

1. Adams, J.C. and Tucker, R.P. (2000) The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development. Dev. Dyn. 218, 280-299.
2. Tan, K., Duquette, M., Liu, J., Dong, Y., Zhang, R., Joachimiak, A., Lawler, J., and Wang, J. (2002) Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. J. Cell Biol. 159(2), 373-382.
3. Iwasaki, W., Nagata, K., Hatanaka, H., Inui, T., Kimura, T., Muramatsu, T., Yoshida, K., Tasumi, M., and Inagaki, F. (1997) Solution structure of midkine, a new heparin-binding growth factor. EMBO J. 16, 6936-6946.
4. Kilpelainen, I., Kaksonen, M., Avikainen, H., Fath, M., Linhardt, R.J., Raulo, E., and Rauvala, H. (2000) Heparin-binding growth-associated molecule contains two heparin-binding beta-sheet domains that are homologous to the thrombospondin type I repeat. J. Biol. Chem. 275, 13564-13570.
5. Rauvala, H., Huttunen, H.J., Fages, C., Kaksonen, M., Kinnunen, T., Imai, S., Raulo, E., and Kilpeläinen, I. (2000) Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility. Matrix Biol. 19, 377-387.
6. Raulo, E., Tumova, S., Pavlov, I., Pekkanen, M., Hienola, A., Klankki, E., Kalkkinen, N., Taira, T., Kilpeläinen, I., and Rauvala, H. (2005) The two thrombospondin type I repeat domains of HB-GAM bind to heparin/heparan sulfate and regulate neurite extension and plasticity in hippocampal neurons. J. Biol. Chem. 280(50), 41576-41583.
7. Rauvala, H. (1989) An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factors. EMBO J. 8, 2933-2941.
8. Raulo, E., Chernousov, M.A., Carey, D., Nolo, R., and Rauvala, H. (1993) Isolation of a neuronal cell surface receptor of HB-GAM (heparin-binding growth-associated molecule); identification as N-syndecan (syndecan-3). J. Biol. Chem. 269, 12999-13004.
9. Lauri, S.E., Taira, T., Kaila, K., and Rauvala, H. (1996) Activity-induced enhancement of HB-GAM expression in rat hippocampal slices. Neuroreport 7, 1670-1674.
10. Lauri, S.E., Rauvala, H., Kaila, K., and Taira, T. (1998) Effect of heparin-binding growth-associated molecule (HB-GAM) on synaptic transmission and early LTP in rat hippocampal slices. Eur. J. Neurosci. 10, 188-194.
11. Pavlov, I., Voikar, V., Kaksonen, M., Lauri, S.E., Hienola, A., Taira, T., and Rauvala, H. (2002) Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice. Mol. Cell. Neurosci. 20, 330-342.
12. Amet, L.E., Lauri, S.E., Hienola, A., Croll, S.D., Lu, Y., Levorse, J.M., Prabhakaran, B., Taira, T., Rauvala, H., and Vogt, T.F. (2001) Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule. Mol. Cell Neurosci. 17, 1014-1024.
13. Lauri, S.E., Kaukinen, S., Kinnunen, T., Ylinen, A., Imai, S., Kaila, K., Taira, T., and Rauvala, H. (1999) Regulatory role and molecular interactions of a cell-surface heparan sulfate proteoglycan (N-syndecan) in hippocampal long-term potentiation. J. Neurosci. 19, 1226-1235.
14. Kaksonen, M., Pavlov, I., Voikar, V., Lauri, S.E., Hienola, A., Riekki, R., Lakso, M., Taira, T., and Rauvala, H. (2002) Syndecan-3 deficient mice exhibit enhanced LTP and impaired hippocampus-dependent memory. Mol. Cell. Neurosci. 21, 158-172.
15. Kinnunen, T., Kaksonen, M., Saarinen, J., Kalkkinen, N., Peng, H.B., and Rauvala, H. (1998) Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. J. Biol. Chem. 273, 10702-10708.
16. Cardin, A.D. and Weintraub, H.J.R. (1989) Molecular modeling of protein-glycosaminoglycan interactions. Arteriosclerosis 9, 21-32.