Stimulated-single fiber electromyography monitoring of anti-sense induced changes in experimental autoimmune myasthenia gravis

Neuroscience Research

Volumn 55, Issue 1, 2006, Pages 40-44

  Boneva, Neli ^a   Hamra Amitay, Yasmine ^a   Wirguin, Itzhak ^b   Brenner, Talma ^a  

^a Agnes Ginges Center for Human Neurogenetics   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Acetylcholinesterase inhibition; Anti sense treatment; Experimental autoimmune myasthenia gravis; Myasthenia gravis; Stimulated single fiber electromyography

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CHOLINESTERASE INHIBITOR; EN 101; PYRIDOSTIGMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG EFFECT; ELECTROMYOGRAPHY; ENZYME INHIBITION; FEMALE; MYASTHENIA GRAVIS; NERVE STIMULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT;

ACETYLCHOLINESTERASE; ANIMALS; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; EXERCISE TEST; FEMALE; MONITORING, PHYSIOLOGIC; MUSCLES; MYASTHENIA GRAVIS, AUTOIMMUNE, EXPERIMENTAL; NEUROMUSCULAR JUNCTION; OLIGONUCLEOTIDES, ANTISENSE; RATS; RATS, INBRED LEW; RECEPTORS, CHOLINERGIC; RNA, MESSENGER; TIME FACTORS;

EID: 33646487206     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2006.01.003     Document Type: Article

References (17)

1. Anglister L., Haesaert B., and McMahan U.J. Globular and asymmetric acetylcholinesterase in the synaptic basal lamina of skeletal muscle. J. Cell Biol. 125 1 (1994) 183-196
2. Boneva N., Brenner T., and Argov Z. Gabapentin may be hazardous in myasthenia gravis. Muscle. Nerve. 23 8 (2000) 1204-1208
3. Brenner T., Hamra-Amitay Y., Evron T., Boneva N., Seidman S., and Soreq H. The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. Faseb J. 17 2 (2003) 214-222
4. Ekstedt J., Nilsson G., and Stalberg E. Calculation of the electromyographic jitter. J. Neurol. Neurosurg. Psychiatry 37 5 (1974) 526-539
5. Grifman M., and Soreq H. Differentiation intensifies the susceptibility of pheochromocytoma cells to antisense oligodeoxynucleotide-dependent suppression of acetylcholinesterase activity. Antisense Nucleic Acid Drug Dev 7 4 (1997) 351-359
6. Galyam N., Grisaru D., Grifman M., Melamed-Book N., Eckstein F., Seidman S., Eldor A., and Soreq H. Complex host cell responses to antisense suppression of ACHE gene expression. Antisense Nucleic Acid Drug Dev. 11 1 (2001) 51-57
7. Legay C., Bon S., Vernier P., Coussen F., and Massoulie J. Cloning and expression of a rat acetylcholinesterase subunit: generation of multiple molecular forms and complementarity with a Torpedo collagenic subunit. J. Neurochem. 60 1 (1993) 337-346
8. Link H., and Xiao B.G. Rat models as tool to develop new immunotherapies. Immunol. Rev. 184 (2001) 117-128
9. Massey J.M., Sanders D.B., and Howard Jr. J.F. The effect of cholinesterase inhibitors of SFEMG in myasthenia gravis. Muscle Nerve 12 2 (1989) 154-155
10. Moran D., Shapiro Y., Meiri U., Laor A., and Horowitz M. Heat acclimation: cardiovascular response to hot/dry and hot/wet heat loads in rats. J. Basic Clin. Physiol. Pharmacol. 7 4 (1996) 375-387
11. McKee D., Agus D., Soreq H., Ben Joseph O., Brawer S., Sussman J., and Argov Z. Antisense therapeutics in myasthenia gravis. J. Neurol. 250 Suppl. 2 (2003) 43
12. Newsom-Davis J. Therapy in myasthenia gravis and Lambert-Eaton myasthenic syndrome. Semin. Neurol. 23 2 (2003) 191-198
13. Seybold M.E., Lambert E.H., Lennon V.A., and Lindstrom J.M. Experimental autoimmune myasthenia: clinical, neurophysiologic, and pharmacologic aspects. Ann. NY. Acad. Sci. 274 (1976) 275-282
14. Stalberg E., and Trontelj J.V. Single Fiber Electromyography: Studies in Healthy and Disease Muscle. (1994), Raven Press, New York pp. 158-177
15. Soreq H., and Seidman S. Acetylcholinesterase - new roles for an old actor. Nat. Rev. Neurosci. 2 4 (2001) 294-302
16. Trontelj J.V., Mihelin M., and Khuraibet A. Safety margin at single neuromuscular junctions. Muscle. Nerve. 11 Suppl. (2002) S21-S27
17. Verschuuren J.J., Spaans F., and De Baets M.H. Single-fiber electromyography in experimental autoimmune myasthenia gravis. Muscle Nerve 13 6 (1990) 485-492