Systemic infections can decrease the threshold of statin-induced muscle injury [2]

Southern Medical Journal

Volumn 99, Issue 4, 2006, Pages 403-404

  Mahboobi, Sohail K ^a   Shohat, Ephron Z ^a   Jellinek, Samantha P ^a   Rose, Malcolm ^a  

^a MAIMONIDES MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; FIBRIC ACID DERIVATIVE; HYDROCHLOROTHIAZIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ACUTE KIDNEY FAILURE; AGED; BACTEREMIA; CASE REPORT; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HUMAN; HYPERLIPIDEMIA; INFECTION; LETTER; MALE; MUSCLE INJURY; MUSCLE WEAKNESS; MYALGIA; RHABDOMYOLYSIS; SYSTEMIC DISEASE;

AGED, 80 AND OVER; BACTEREMIA; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HEART VALVE PROSTHESIS; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KIDNEY FAILURE, ACUTE; MALE; MUSCULAR DISEASES; PYRROLES;

EID: 33646483036     PISSN: 00384348     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.smj.0000209273.52754.86     Document Type: Letter

References (5)

1. Finsterer J, Zuntner G. Rhabdomyolysis from simvastatin triggered by infection and muscle exertion. South Med J 2005;98:827-829.
2. Ucar M, Mjorndal T, Dahlqvist R. HMG-CoA reductase inhibitors and myotoxicity. Drug Saf 2000;22:441-457.
3. Flint OP, Masters BA, Gregg RE, Durham SK. HMG-CoA inhibitor-induced myotoxicity: pravastatin and lovastatin inhibit the geranylgeranyolation of low-molecular-weight proteins in neonatal rat muscle cell culture. Toxicol Appl Pharmacol 1997;145:99-110.
4. Betrosian A, Thireos E, Kofinas G, et al. Bacterial sepsis-induced rhabdomyolysis. Intensive Care Med 1999;25:469-474.
5. Liappis AP, Kan VL, Rochester CG, Simon GL. The effect of statins on mortality in patients with bacteremia. Clin Infect Dis 2001;33:1352-1357.