Probably anti-Tr associated paraneoplastic cerebellar degeneration as initial presentation of a squamous cell carcinoma of the lung

Clinical Neurology and Neurosurgery

Volumn 108, Issue 4, 2006, Pages 415-417

  Bruylant, K ^a   Crols, R ^a   Humbel, R L ^b   Appel, B ^a   De Deyn, P P ^a  

^a MIDDELHEIM HOSPITAL   (Belgium)

^b CENTRE HOSPITALIER DE LUXEMBOURG   (Luxembourg)

Author keywords

Anti Purkinje cell antibodies; Anti Tr antibody; Non well differentiated squamous cell carcinoma; Paraneoplastic cerebellar degeneration

Indexed keywords

GEMCITABINE; RECEPTOR ANTIBODY; THYROID HORMONE RECEPTOR;

AGED; ANTIBODY BLOOD LEVEL; ARTICLE; ATAXIA; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CASE REPORT; CLINICAL FEATURE; DIAGNOSTIC PROCEDURE; DYSARTHRIA; HUMAN; LEG; LUNG HILUS; LUNG SQUAMOUS CELL CARCINOMA; MALE; MEDIASTINOSCOPY; PARANEOPLASTIC NEUROPATHY; PATHOLOGY; POSITRON EMISSION TOMOGRAPHY;

AGED; ANTIBODIES; BRAIN; BRONCHOSCOPY; CARCINOMA, SQUAMOUS CELL; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; NERVE TISSUE PROTEINS; PARANEOPLASTIC CEREBELLAR DEGENERATION;

EID: 33646478137     PISSN: 03038467     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clineuro.2005.01.008     Document Type: Article

References (11)

1. Posner J.B., and Furneaux H.M. Paraneoplastic syndromes. Immunologic mechanisms. In: Waksman B.H. (Ed). Neurologic and psychiatric disease (1990), Raven Press, New York 187-219
2. Raymond V. Paraneoplastic neurological syndromes: an update on diagnosis, pathogenesis and therapy. The Lancet Neurol (2002) 1294-1305
3. Trotter J.L., Hendin B.A., and Osterland C.K. Cerebellar degeneration with Hodgkin's disease: an immunological study. Arch Neurol 33 (1976) 660-661
4. Graus F., Dalmau J., Valldeorida F., et al. Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease. J Neuroimmunol 74 (1997) 55-61
5. Setareh S., Joost G., de Leeuw B., van den Bent M., et al. Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients. Brain 126 (2003) 1409-1418
6. Francesco S., Shu F.A., Michael G., and Maria T. The neuropathology of paraneoplastic syndromes. Brain Pathol 9 (1999) 251-260
7. Graus F., Humayun Gultekin S., Ferrer I., Reiriz J., Alberch J., and Dalmau J. Localization of the neuronal antigen recognized by anti-Tr antibodies from patients with paraneoplastic cerebellar degeneration and Hodgkin's disease in the rat nervous system. Acta Neuropathol 96 (1998) 1-7
8. Bernal F., et al. Anti-Tr antibodies as markers of paraneoplastic cerebellar degeneration and Hodgkin's disease. Neurology 60 (2003) 230-234
9. Luis B., Deborly F.W., Francesc G., Myrna R.R., and Josep D. The MAZ protein is an autoantigen of Hodgkin's disease and paraneoplastic cerebellar degeneration. Ann Neurol 53 (2003) 123-127
10. Rees J.H., Hain S.F., Johnson M.R., et al. The role of [18F]fluoro-2deoxyglucose-PET scanning in the diagnosis of paraneoplastic neurological disorders. Brain 124 (2001) 2223-2231
11. Keime-Ginbert F., Graus F., Fleury A., et al. Treatment of paraneoplastic neurological syndromes with antineuronal antibodies (anti-Hu, anti-Yo) with a combination of immunoglobulines, cyclophosphamide and methylprednisone. J Neurol Neurosurg Psychiat 68 (2000) 479-482