-
1
-
-
0142089747
-
Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
-
Raper SE, Chirmule N, Lee FS et al.: Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol. Genet. Metab. 80, 148-158 (2003)
-
(2003)
Mol. Genet. Metab.
, vol.80
, pp. 148-158
-
-
Raper, S.E.1
Chirmule, N.2
Lee, F.S.3
-
2
-
-
2442635383
-
Modified adenoviruses for cancer gene therapy
-
Kanerva A, Hemminki A: Modified adenoviruses for cancer gene therapy. Int. J. Cancer 110, 475-480 (2004)
-
(2004)
Int. J. Cancer
, vol.110
, pp. 475-480
-
-
Kanerva, A.1
Hemminki, A.2
-
3
-
-
4444219732
-
Transductional targeting of adenoviral cancer gene therapy
-
Everts M, Curiel DT: Transductional targeting of adenoviral cancer gene therapy. Curr. Gene Ther. 4, 337-346 (2004)
-
(2004)
Curr. Gene Ther.
, vol.4
, pp. 337-346
-
-
Everts, M.1
Curiel, D.T.2
-
4
-
-
4143092630
-
Use of replicating oncolytic adenoviruses in combination therapy for cancer
-
Chu RL, Post DE, Khuri FR, Van Meir EG: Use of replicating oncolytic adenoviruses in combination therapy for cancer. Clin. Cancer Res. 10, 5299-5312 (2004)
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 5299-5312
-
-
Chu, R.L.1
Post, D.E.2
Khuri, F.R.3
Van Meir, E.G.4
-
5
-
-
0141457772
-
Replicating adenoviruses in cancer therapy
-
Dobbelstein M: Replicating adenoviruses in cancer therapy. Curr. Top. Microbiol. Immunol. 273291-27334 (2004)
-
(2004)
Curr. Top. Microbiol. Immunol.
, pp. 273291-327334
-
-
Dobbelstein, M.1
-
6
-
-
0037509944
-
A novel hypoxiainducible factor (HIF) activated oncolytic adenovirus for cancer therapy
-
Post DE, Van Meir EG: A novel hypoxiainducible factor (HIF) activated oncolytic adenovirus for cancer therapy. Oncogene 22, 2065-2072 (2003)
-
(2003)
Oncogene
, vol.22
, pp. 2065-2072
-
-
Post, D.E.1
Van Meir, E.G.2
-
7
-
-
11144229120
-
Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors
-
Post DE, Devi NS, Li Z et al.: Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors. Clin. Cancer Res. 10, 8603-8612 (2004)
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 8603-8612
-
-
Post, D.E.1
Devi, N.S.2
Li, Z.3
-
8
-
-
0037155890
-
YB- 1 relocates to the nucleus in adenovirusinfected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter
-
Holm PS, Bergmann S, Jurchott K et al.: YB- 1 relocates to the nucleus in adenovirusinfected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter. J. Biol. Chem. 277, 10427-10434 (2002)
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 10427-10434
-
-
Holm, P.S.1
Bergmann, S.2
Jurchott, K.3
-
9
-
-
9144240419
-
Multidrug-resistant cancer cells facilitate E1-independent adenoviral replication: Impact for cancer gene therapy
-
Holm PS, Lage H, Bergmann S et al.: Multidrug-resistant cancer cells facilitate E1-independent adenoviral replication: impact for cancer gene therapy. Cancer Res. 64, 322-328 (2004)
-
(2004)
Cancer Res.
, vol.64
, pp. 322-328
-
-
Holm, P.S.1
Lage, H.2
Bergmann, S.3
-
10
-
-
0036682166
-
Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors
-
Haviv YS, Blackwell JL, Kanerva A et al.: Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors. Cancer Res. 62, 4273-4281 (2002)
-
(2002)
Cancer Res.
, vol.62
, pp. 4273-4281
-
-
Haviv, Y.S.1
Blackwell, J.L.2
Kanerva, A.3
-
11
-
-
0033565515
-
Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas
-
Shinoura N, Yoshida Y, Tsunoda R et al.: Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas. Cancer Res. 59, 3411-3416 (1999)
-
(1999)
Cancer Res.
, vol.59
, pp. 3411-3416
-
-
Shinoura, N.1
Yoshida, Y.2
Tsunoda, R.3
-
12
-
-
0035138689
-
A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency
-
Suzuki K, Fueyo J, Krasnykh V et al.: A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency. Clin. Cancer Res. 7, 120-126 (2001)
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 120-126
-
-
Suzuki, K.1
Fueyo, J.2
Krasnykh, V.3
-
14
-
-
0036901290
-
Adenoviral vectors: Systemic delivery and tumor targeting
-
Green NK and Seymour LW: Adenoviral vectors: systemic delivery and tumor targeting. Cancer Gene Ther. 9, 1036-1042 (2002)
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 1036-1042
-
-
Green, N.K.1
Seymour, L.W.2
-
15
-
-
0035077806
-
Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies
-
Fisher KD, Stallwood Y, Green NK et al.: Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies. Gene Ther. 8, 341-348 (2001)
-
(2001)
Gene Ther.
, vol.8
, pp. 341-348
-
-
Fisher, K.D.1
Stallwood, Y.2
Green, N.K.3
-
16
-
-
19944430495
-
Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells
-
Maeda M, Kida S, Hojo K et al.: Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells. Bioorg. Med. Chem. Lett. 15, 621-624 (2005)
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 621-624
-
-
Maeda, M.1
Kida, S.2
Hojo, K.3
-
17
-
-
0344188096
-
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
-
Bischoff JR, Kirn DH, Williams A et al.: An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 274, 373-376 (1996)
-
(1996)
Science
, vol.274
, pp. 373-376
-
-
Bischoff, J.R.1
Kirn, D.H.2
Williams, A.3
-
18
-
-
0031798440
-
P53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection
-
Goodrum FD, Ornelles DA: p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection. J. Virol. 72, 9479-9490 (1998)
-
(1998)
J. Virol.
, vol.72
, pp. 9479-9490
-
-
Goodrum, F.D.1
Ornelles, D.A.2
-
19
-
-
1642430625
-
Functions and mechanisms of action of the adenovirus E3 proteins
-
Lichtenstein DL, Toth K, Doronin K, Tollefson AE, Wold WS: Functions and mechanisms of action of the adenovirus E3 proteins. Int. Rev. Immunol. 23, 75-111 (2004)
-
(2004)
Int. Rev. Immunol.
, vol.23
, pp. 75-111
-
-
Lichtenstein, D.L.1
Toth, K.2
Doronin, K.3
Tollefson, A.E.4
Wold, W.S.5
-
20
-
-
0033199188
-
The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts
-
Yu DC, Chen Y, Seng M, Dilley J, Henderson DR: The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts. Cancer Res. 59, 4200-4203 (1999)
-
(1999)
Cancer Res.
, vol.59
, pp. 4200-4203
-
-
Yu, D.C.1
Chen, Y.2
Seng, M.3
Dilley, J.4
Henderson, D.R.5
-
21
-
-
0036846643
-
The presence of the adenovirus E3 region improves the oncolytic potency of conditionally replicative adenoviruses
-
Suzuki K, Alemany R, Yamamoto M, Curiel DT: The presence of the adenovirus E3 region improves the oncolytic potency of conditionally replicative adenoviruses. Clin. Cancer Res. 8, 3348-3359 (2002)
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3348-3359
-
-
Suzuki, K.1
Alemany, R.2
Yamamoto, M.3
Curiel, D.T.4
-
22
-
-
0034086730
-
Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein
-
Doronin K, Toth K, Kuppuswamy M et al.: Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein. J. Virol. 74, 6147-6155 (2000)
-
(2000)
J. Virol.
, vol.74
, pp. 6147-6155
-
-
Doronin, K.1
Toth, K.2
Kuppuswamy, M.3
-
23
-
-
0037455562
-
Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus
-
Doronin K, Toth K, Kuppuswamy M et al.: Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus. Virology 305, 378-387 (2003)
-
(2003)
Virology
, vol.305
, pp. 378-387
-
-
Doronin, K.1
Toth, K.2
Kuppuswamy, M.3
-
24
-
-
0037457032
-
Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: Virus persists and spreads systemically at late time points
-
Sauthoff H, Hu J, Maca C et al.: Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points. Hum. Gene Ther. 14, 425-433 (2003)
-
(2003)
Hum. Gene Ther.
, vol.14
, pp. 425-433
-
-
Sauthoff, H.1
Hu, J.2
Maca, C.3
-
25
-
-
0242290921
-
E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models
-
Wang Y, Hallden G, Hill R et al.: E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models. Nature Biotechnol. 21, 1328-1335 (2003)
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 1328-1335
-
-
Wang, Y.1
Hallden, G.2
Hill, R.3
-
26
-
-
17944371743
-
Gene delivery from the E3 region of replicating human adenovirus: Evaluation of the 6.7 K/gp19 K region
-
Hawkins LK, Johnson L, Bauzon M et al.: Gene delivery from the E3 region of replicating human adenovirus: evaluation of the 6.7 K/gp19 K region. Gene Ther. 8, 1123-1131 (2001)
-
(2001)
Gene Ther.
, vol.8
, pp. 1123-1131
-
-
Hawkins, L.K.1
Johnson, L.2
Bauzon, M.3
-
27
-
-
0034161976
-
In vivo anti-tumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy
-
Rogulski KR, Freytag SO, Zhang K et al.: In vivo anti-tumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy. Cancer Res. 60, 1193-1196 (2000)
-
(2000)
Cancer Res.
, vol.60
, pp. 1193-1196
-
-
Rogulski, K.R.1
Freytag, S.O.2
Zhang, K.3
-
28
-
-
0036468548
-
Oncolytic activity of the E1B-55 kDadeleted adenovirus ONYX-015 is independent of cellular p53 status in human malignant glioma xenografts
-
Geoerger B, Grill J, Opolon P et al.: Oncolytic activity of the E1B-55 kDadeleted adenovirus ONYX-015 is independent of cellular p53 status in human malignant glioma xenografts. Cancer Res. 62, 764-772 (2002)
-
(2002)
Cancer Res.
, vol.62
, pp. 764-772
-
-
Geoerger, B.1
Grill, J.2
Opolon, P.3
-
29
-
-
0036182298
-
Efficient induction of apoptosis by ONYX- 015 adenovirus in human colon cancer cell lines regardless of p53 status
-
Petit T, Davidson KK, Cerna C et al.: Efficient induction of apoptosis by ONYX- 015 adenovirus in human colon cancer cell lines regardless of p53 status. Anticancer Drugs 13, 47-50 (2002)
-
(2002)
Anticancer Drugs
, vol.13
, pp. 47-50
-
-
Petit, T.1
Davidson, K.K.2
Cerna, C.3
-
30
-
-
0033623250
-
Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015)
-
Ries SJ, Brandts CH, Chung AS et al.: Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015). Nature Med. 6, 1128-1133 (2000)
-
(2000)
Nature Med.
, vol.6
, pp. 1128-1133
-
-
Ries, S.J.1
Brandts, C.H.2
Chung, A.S.3
-
31
-
-
19944363519
-
Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
-
O'Shea C C, Johnson L, Bagus B et al.: Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell 6, 611-623 (2004)
-
(2004)
Cancer Cell
, vol.6
, pp. 611-623
-
-
O'Shea, C.C.1
Johnson, L.2
Bagus, B.3
-
32
-
-
0032503659
-
A novel threepronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy
-
Freytag SO, Rogulski KR, Paielli DL, Gilbert JD, and Kim JH: A novel threepronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy. Hum. Gene Ther. 9, 1323-1333 (1998)
-
(1998)
Hum. Gene Ther.
, vol.9
, pp. 1323-1333
-
-
Freytag, S.O.1
Rogulski, K.R.2
Paielli, D.L.3
Gilbert, J.D.4
Kim, J.H.5
-
33
-
-
0030790684
-
Prostate attenuated replication competent adenovirus (ARCA) CN706: A selective cytotoxic for prostate-specific antigenpositive prostate cancer cells
-
Rodriguez R, Schuur ER, Lim HY et al.: Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigenpositive prostate cancer cells. Cancer Res. 57, 2559-2563 (1997)
-
(1997)
Cancer Res.
, vol.57
, pp. 2559-2563
-
-
Rodriguez, R.1
Schuur, E.R.2
Lim, H.Y.3
-
34
-
-
0030917202
-
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and anti-tumoral efficacy that can be augmented by standard chemotherapeutic agents
-
Heise C, Sampson-Johannes A, Williams A et al.: ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and anti-tumoral efficacy that can be augmented by standard chemotherapeutic agents. Nature Med. 3, 639-645 (1997)
-
(1997)
Nature Med.
, vol.3
, pp. 639-645
-
-
Heise, C.1
Sampson-Johannes, A.2
Williams, A.3
-
35
-
-
0035876455
-
Does detection of circulating ONYX-015 genome by polymerase chain reaction indicate vector replication?
-
Yver A: Does detection of circulating ONYX-015 genome by polymerase chain reaction indicate vector replication? J. Clin. Oncol. 19, 3155-3157 (2001)
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 3155-3157
-
-
Yver, A.1
-
36
-
-
12244294478
-
Persistent replication of the modified chimeric adenovirus ONYX-015 in both tumor and stromal cells from a patient with gall bladder carcinoma implants
-
Wadler S, Yu B, Tan JY, et al.: Persistent replication of the modified chimeric adenovirus ONYX-015 in both tumor and stromal cells from a patient with gall bladder carcinoma implants. Clin. Cancer Res. 9, 33-43 (2003)
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 33-43
-
-
Wadler, S.1
Yu, B.2
Tan, J.Y.3
-
37
-
-
0034088225
-
Diffusion MRI detects early events in the response of a glioma model to the yeast cytosine deaminase gene therapy strategy
-
Stegman LD, Rehemtulla A, Hamstra DA et al.: Diffusion MRI detects early events in the response of a glioma model to the yeast cytosine deaminase gene therapy strategy. Gene Ther. 7, 1005-1010 (2000)
-
(2000)
Gene Ther.
, vol.7
, pp. 1005-1010
-
-
Stegman, L.D.1
Rehemtulla, A.2
Hamstra, D.A.3
-
38
-
-
0036828054
-
PET imaging of gene expression
-
Blasberg R: PET imaging of gene expression. Eur. J. Cancer 38, 2137-2146 (2002)
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 2137-2146
-
-
Blasberg, R.1
-
39
-
-
0035448565
-
Positron-emission tomography of vectormediated gene expression in gene therapy for gliomas
-
Jacobs A, Voges J, Reszka R, et al.: Positron-emission tomography of vectormediated gene expression in gene therapy for gliomas. Lancet 358, 727-729 (2001)
-
(2001)
Lancet
, vol.358
, pp. 727-729
-
-
Jacobs, A.1
Voges, J.2
Reszka, R.3
-
40
-
-
2442562277
-
A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging
-
Ponomarev V, Doubrovin M, Serganova I et al.: A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. Eur. J. Nucl. Med. Mol. Imaging 31, 740-751 (2004)
-
(2004)
Eur. J. Nucl. Med. Mol. Imaging
, vol.31
, pp. 740-751
-
-
Ponomarev, V.1
Doubrovin, M.2
Serganova, I.3
-
41
-
-
7244224698
-
The use of 19F spectroscopy and diffusionweighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies
-
Hamstra DA, Lee KC, Tychewicz JM et al.: The use of 19F spectroscopy and diffusionweighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies. Mol. Ther. 10, 916-928 (2004)
-
(2004)
Mol. Ther.
, vol.10
, pp. 916-928
-
-
Hamstra, D.A.1
Lee, K.C.2
Tychewicz, J.M.3
-
42
-
-
0033782862
-
An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy
-
Heise C, Hermiston T, Johnson L et al.: An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy. Nature Med. 6, 1134-1139 (2000)
-
(2000)
Nature Med.
, vol.6
, pp. 1134-1139
-
-
Heise, C.1
Hermiston, T.2
Johnson, L.3
-
43
-
-
0034610723
-
A mutant oncolytic adenovirus targeting the Rb pathway produces anti- glioma effect in vivo
-
Fueyo J, Gomez-Manzano C, Alemany R et al.: A mutant oncolytic adenovirus targeting the Rb pathway produces anti- glioma effect in vivo. Oncogene 19, 2-12 (2000)
-
(2000)
Oncogene
, vol.19
, pp. 2-12
-
-
Fueyo, J.1
Gomez-Manzano, C.2
Alemany, R.3
-
44
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL: Targeting HIF-1 for cancer therapy. Nature Rev. Cancer 3, 721-732 (2003)
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
45
-
-
12944328660
-
A Phase i study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer
-
Ganly I, Kirn D, Eckhardt G et al.: A Phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer. Clin. Cancer Res. 6, 798-806 (2000)
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 798-806
-
-
Ganly, I.1
Kirn, D.2
Eckhardt, G.3
-
46
-
-
0035076823
-
Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replicationselective adenovirus (ONYX-015) into primary carcinomas of the pancreas: A Phase i trial
-
Mulvihill S, Warren R, Venook A et al.: Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replicationselective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a Phase I trial. Gene Ther. 8, 308-315 (2001)
-
(2001)
Gene Ther.
, vol.8
, pp. 308-315
-
-
Mulvihill, S.1
Warren, R.2
Venook, A.3
-
47
-
-
0035177690
-
Intraarterial administration of a replicationselective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: A Phase i trial
-
Reid T, Galanis E, Abbruzzese J et al.: Intraarterial administration of a replicationselective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a Phase I trial. Gene Ther. 8, 1618-1626 (2001)
-
(2001)
Gene Ther.
, vol.8
, pp. 1618-1626
-
-
Reid, T.1
Galanis, E.2
Abbruzzese, J.3
-
48
-
-
0035835373
-
E1Bdeleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors
-
Habib NA, Sarraf CE, Mitry RR et al.: E1Bdeleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors. Hum. Gene Ther. 12, 219-226 (2001)
-
(2001)
Hum. Gene Ther.
, vol.12
, pp. 219-226
-
-
Habib, N.A.1
Sarraf, C.E.2
Mitry, R.R.3
-
49
-
-
0034990761
-
Intravenous infusion of a replicationselective adenovirus (ONYX-015) in cancer patients: Safety, feasibility and biological activity
-
Nemunaitis J, Cunningham C, Buchanan A et al.: Intravenous infusion of a replicationselective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity. Gene Ther. 8, 746-759 (2001)
-
(2001)
Gene Ther.
, vol.8
, pp. 746-759
-
-
Nemunaitis, J.1
Cunningham, C.2
Buchanan, A.3
-
50
-
-
12444281703
-
Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX- 015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients
-
Nemunaitis J, Cunningham C, Tong AW et al.: Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX- 015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients. Cancer Gene Ther. 10, 341-352 (2003)
-
(2003)
Cancer Gene Ther.
, vol.10
, pp. 341-352
-
-
Nemunaitis, J.1
Cunningham, C.2
Tong, A.W.3
-
51
-
-
0037087621
-
Phase i trial of intraperitoneal injection of the E1B-55-kd-gene-deleted adenovirus ONYX-015 (dl1520) given on days 1 through 5 every 3 weeks in patients with recurrent/refractory epithelial ovarian cancer
-
Vasey PA, Shulman LN, Campos S et al.: Phase I trial of intraperitoneal injection of the E1B-55-kd-gene-deleted adenovirus ONYX-015 (dl1520) given on days 1 through 5 every 3 weeks in patients with recurrent/refractory epithelial ovarian cancer. J. Clin. Oncol. 20, 1562-1569 (2002)
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 1562-1569
-
-
Vasey, P.A.1
Shulman, L.N.2
Campos, S.3
-
52
-
-
7044228126
-
A Phase i Open-Label, Dose-Escalation, Multi-Institutional Trial of Injection with an E1B-Attenuated Adenovirus, ONYX- 015, into the Peritumoral Region of Recurrent Malignant Gliomas, in the Adjuvant Setting
-
Chiocca EA, Abbed KM, Tatter S et al.: A Phase I Open-Label, Dose-Escalation, Multi-Institutional Trial of Injection with an E1B-Attenuated Adenovirus, ONYX- 015, into the Peritumoral Region of Recurrent Malignant Gliomas, in the Adjuvant Setting. Mol. Ther. 10, 958-966 (2004)
-
(2004)
Mol. Ther.
, vol.10
, pp. 958-966
-
-
Chiocca, E.A.1
Abbed, K.M.2
Tatter, S.3
-
53
-
-
1542438707
-
An attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia
-
Rudin CM, Cohen EE, Papadimitrakopoulou VA et al.: An attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia. J Clin. Oncol. 21, 4546-4552 (2003)
-
(2003)
J Clin. Oncol.
, vol.21
, pp. 4546-4552
-
-
Rudin, C.M.1
Cohen, E.E.2
Papadimitrakopoulou, V.A.3
-
54
-
-
0035887153
-
A Phase i trial of CV706, a replicationcompetent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy
-
DeWeese TL, van der Poel H, Li S et al.: A Phase I trial of CV706, a replicationcompetent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy. Cancer Res. 61, 7464-7472. (2001)
-
(2001)
Cancer Res.
, vol.61
, pp. 7464-7472
-
-
Deweese, T.L.1
Van Der Poel, H.2
Li, S.3
-
55
-
-
0036733759
-
Phase i study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer
-
Freytag SO, Khil M, Stricker H et al.: Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res. 62, 4968-4976 (2002)
-
(2002)
Cancer Res.
, vol.62
, pp. 4968-4976
-
-
Freytag, S.O.1
Khil, M.2
Stricker, H.3
-
56
-
-
10744227813
-
Phase i study of replication-competent adenovirusmediated double-suicide gene therapy in combination with conventional-dose threedimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer
-
Freytag SO, Stricker H, Pegg J et al.: Phase I study of replication-competent adenovirusmediated double-suicide gene therapy in combination with conventional-dose threedimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer. Cancer Res. 63, 7497-7506 (2003)
-
(2003)
Cancer Res.
, vol.63
, pp. 7497-7506
-
-
Freytag, S.O.1
Stricker, H.2
Pegg, J.3
-
57
-
-
0033693231
-
Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B- 55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: A Phase II trial
-
Nemunaitis J, Ganly I, Khuri F et al.: Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B- 55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a Phase II trial. Cancer Res. 60, 6359-6366 (2000)
-
(2000)
Cancer Res.
, vol.60
, pp. 6359-6366
-
-
Nemunaitis, J.1
Ganly, I.2
Khuri, F.3
-
58
-
-
0035863458
-
Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer
-
Nemunaitis J, Khuri F, Ganly I et al.: Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer. J. Clin. Oncol. 19, 289-298 (2001)
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 289-298
-
-
Nemunaitis, J.1
Khuri, F.2
Ganly, I.3
-
59
-
-
0033835016
-
A prospective Phase II trial of ONYX-015 adenovirus and chemotherapy in recurrent squamous cell carcinoma of the head and neck (the Baylor experience)
-
Lamont JP, Nemunaitis J, Kuhn JA, Landers SA, and McCarty TM: A prospective Phase II trial of ONYX-015 adenovirus and chemotherapy in recurrent squamous cell carcinoma of the head and neck (the Baylor experience). Ann. Surg. Oncol. 7, 588-592. (2000)
-
(2000)
Ann. Surg. Oncol.
, vol.7
, pp. 588-592
-
-
Lamont, J.P.1
Nemunaitis, J.2
Kuhn, J.A.3
Landers, S.A.4
McCarty, T.M.5
-
60
-
-
0033831080
-
A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5- fluorouracil in patients with recurrent head and neck cancer
-
Khuri FR, Nemunaitis J, Ganly I et al.: A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5- fluorouracil in patients with recurrent head and neck cancer. Nature Med. 6, 879-885. (2000)
-
(2000)
Nature Med.
, vol.6
, pp. 879-885
-
-
Khuri, F.R.1
Nemunaitis, J.2
Ganly, I.3
-
61
-
-
0037314610
-
A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX- 015 with intravenous gemcitabine in unresectable pancreatic carcinoma
-
Hecht JR, Bedford R, Abbruzzese JL et al.: A Phase I/II Trial of Intratumoral Endoscopic Ultrasound Injection of ONYX- 015 with Intravenous Gemcitabine in Unresectable Pancreatic Carcinoma. Clin. Cancer Res. 9, 555-561 (2003)
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 555-561
-
-
Hecht, J.R.1
Bedford, R.2
Abbruzzese, J.L.3
-
62
-
-
0037314655
-
Phase II clinical trial of intralesional administration of the oncolytic adenovirus ONYX-015 in patients with hepatobiliary tumors with correlative p53 studies
-
Makower D, Rozenblit A, Kaufman H et al.: Phase II clinical trial of intralesional administration of the oncolytic adenovirus ONYX-015 in patients with hepatobiliary tumors with correlative p53 studies. Clin. Cancer Res. 9, 693-702 (2003)
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 693-702
-
-
Makower, D.1
Rozenblit, A.2
Kaufman, H.3
-
63
-
-
0036828125
-
Hepatic arterial infusion of a replicationselective oncolytic adenovirus (dl1520): Phase II viral, immunologic, and clinical endpoints
-
Reid T, Galanis E, Abbruzzese J et al.: Hepatic arterial infusion of a replicationselective oncolytic adenovirus (dl1520): Phase II viral, immunologic, and clinical endpoints. Cancer Res. 62, 6070-6079 (2002)
-
(2002)
Cancer Res.
, vol.62
, pp. 6070-6079
-
-
Reid, T.1
Galanis, E.2
Abbruzzese, J.3
-
64
-
-
0038518576
-
Phase II trial of intravenous CI-1042 in patients with metastatic colorectal cancer
-
Hamid O, Varterasian ML, Wadler S et al.: Phase II trial of intravenous CI-1042 in patients with metastatic colorectal cancer. J. Clin. Oncol. 21, 1498-1504 (2003)
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 1498-1504
-
-
Hamid, O.1
Varterasian, M.L.2
Wadler, S.3
-
65
-
-
3042770838
-
The dl1520 virus is found preferentially in tumor tissue after direct intratumoral injection in oral carcinoma
-
101 Accessed March 2005
-
Morley S, MacDonald G, Kirn D et al.: The dl1520 virus is found preferentially in tumor tissue after direct intratumoral injection in oral carcinoma. Clin. Cancer Res. 10, 4357-4362 (2004). 101 www.onyx-pharm.com (Accessed March 2005)
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 4357-4362
-
-
Morley, S.1
Macdonald, G.2
Kirn, D.3
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