Design, synthesis and insulin-sensitizing activity of indole derivatives

Yaoxue Xuebao

Volumn 41, Issue 3, 2006, Pages 225-229

  Tang, Lei ^a   Yang, Yu She ^b   Ji, Ru Yun ^b  

^a GUIZHOU MEDICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

3T3 L1 cell; Insulin sensitizing activity; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; INDOLE DERIVATIVE; INSULIN; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL; ARTICLE; CELL STRAIN 3T3; DRUG DESIGN; DRUG EFFECT; METABOLISM; MOUSE; SYNTHESIS;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; DRUG DESIGN; HYPOGLYCEMIC AGENTS; INDOLES; INSULIN; MICE; TRIGLYCERIDES;

EID: 33646460590     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Yang ZC. Pharmacology and Pharmaceutical Therapeutics [M]. Beijing: People's Medical Publishing House, 2000:1273.
2. Shinkai H. Novel antidiabetic agents [J]. Exp Opin Ther Patents, 2000,10:59-66.
3. Sohda T, Mizuno K, Imamiya K, et al. Studies on antidiabetic agents. II. Synthesis of 5-[4-( 1-methylcyclohexyl-methoxy) benzyl] thiazolidine-2,4-dione (ADD-3878) and its derivatives [J]. Chem Pharm Bull, 1982,30:3580-3600.
4. Yoshioka T, Fujita T, Kanai T, et al. Studies on hindered phenols and analogues. 1. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation [J]. J Med Chem, 1989,32:421-428.
5. Momose Y, Meguro K, Ikeda H, et al. Studies on antidiabetic agents. X. Synthesis and biological activities of pioglitazone and related compoundes [J]. Chem Pharm Bull, 1991,39:1440-1445.
6. Cantello BCC, Cawthorne MA, Cottam GP, et al. {[ω-( Hetrocyclylamino) alkoxy] benzyl} -2,4-thiazolidinediones as potent antihyperglycemic agents [J]. J Med Chem, 1994,37:3977-3985.
7. Henry RR. Thiazolidinediones [J]. Endocrinol Metab Clin North Am, 1997,26:553-573.
8. Smithkline Beecham PLC (GB). Heterocyclic derivatives and their use in pharmaceuticals; World, 9413650[P]. 1994-06-23.
9. Loray BB, Bhushan V, Bheema PR, et al. Novel euglycemic and hypolipidemic agents [J]. J Med Chem, 1998,41:1619-1630.
10. Shinkai H, Onogi S, Tanaka M, et al. Isoazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents [J]. J Med Chem, 1998,41:1927-1933.