Optimization of the sucrose and ion concentrations for saikosaponin production in hairy root culture of Bupleurum falcatum

Biotechnology and Bioprocess Engineering

Volumn 11, Issue 2, 2006, Pages 121-126

  Ahn, Jun Cheul ^a   Chong, Won Seog ^a   Kim, Young Soon ^b   Hwang, Baik ^b  

^a Seonam University   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Hairy root; Macro nutrients; Productivity; Saikosaponin; Sucrose

Indexed keywords

BUPLEURUM FALCATUM EXTRACT; NITROGEN; PHOSPHATE; PLANT EXTRACT; POTASSIUM; SAIKOSAPONIN; SUCROSE; UNCLASSIFIED DRUG;

ARTICLE; BUPLEURUM; BUPLEURUM FALCATUM; CARBOHYDRATE ANALYSIS; CONTROLLED STUDY; CULTURE MEDIUM; DRUG DETERMINATION; HAIRY ROOT CULTURE; NONHUMAN; PROCESS OPTIMIZATION; ROOT GROWTH;

BUPLEURUM; BUPLEURUM FALCATUM;

EID: 33646427455     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02931895     Document Type: Article

References (41)

1. Wang, Y. Z. and Y. Y. Zhang (1994) Determination of species of medicinal Bupleurum. Chinese Pharmaceutical J. 29: 16-18.
2. Yamamoto, M., A. Kumagai, and Y. Yamamura (1975) Structure and actions of saikosaponin isolated from Bupleurum falcatum L. II. Metabolic actions of saikosaponins, especially a plasma cholesterol-lowering action. Arzneimittelforschung 25: 1240-1243.
3. Kita, T., T. Hata, E. Itoh, and R. Yoneda (1980) Analgesic and other pharmacological actions of saikosaponin in repeated cold stress (SART stressed) animals. J. Pharmacobio-dyn. 3: 269-280.
4. Just, J., C. Recio, R. Giner, M. J. Cuellar, S. Manez, J. L. Rios, A. R. Bilia, and I. Morelli (1996) Preliminary study of the pharmacology and phytochemistry of Bupleurum rotundifolium. Phytother. Res. 10: S69-S70.
5. Abe, H., M. Sakaguchi, H. Konishi, T. Tani, and S. Arichi (1978) The effects of saikosaponins on biological membranes. 1. The relationship between the structures of saikosaponins and hemolytic activity. Planta Med. 34: 160-166.
6. Nose, M., S. Amagaya, and Y. Ogihara (1989) Effects of saikosaponin metabolites on the hemolysis of red blood cells and their adsorbability on the cell membrane. Chem. Pharm. Bull. 37: 3306-3310.
7. Abe, H., S. Odashima, and S. Arichi (1978) The effects of saikosaponins on biological membranes. 2. Changes in electron spin resonance spectra from spin-labelled erythrocyte ghost membranes. Planta Med. 34: 287-290.
8. Ushino, Y. and H. Abe (1991) Effects of saikosaponin d on the functions and morphology of macrophages. Int. J. Immunopharmacol. 13: 493-499.
9. Ushino, Y. and H. Abe (1991) The effects of saikosaponin on macrophage functions and lymphocyte proliferation. Planta Med. 57: 511-514.
10. Ushino, Y. and H. Abe (1992) Inactivation of measles virus and herpes simplex virus by saikosaponin d. Planta Med. 58: 171-173.
11. Lee, K. T., B. J. Kim, J. H. Kim, M. Y. Heo, and H. P. Kim (1997) Biological screening of 100 plant extracts for cosmetic use (I): inhibitory activities of tyrosinase and DOPA auto-oxidation. Int. J. Cosmet. Sci. 19: 291-298.
12. Nishiyama, T., N. Akutsu, and Y. Nakayama (1999). Effects of saikosaponin b1 on the synthesis of VII type collagen. Seikagaku 71: 889.
13. Kim, K. S., Y. A. Chae, and B. H. Lee (2000) Comparison of saikosaponin content in Bupleurum falcatum L. cultivars, 'Jeongsun' and 'Mishima'. Kor. J. Breed. 32: 233-238.
14. Shimokawa. Y., I. Okuda, M. Kuwano, and H. Ohashi (1980) Cultivation and breeding of Bupleurum falcatum L. (VI). Geographical variation of B. falcatum. Jap. J. Pharmacogn. 34: 239-244.
15. Tanaka, T., E. Sakai, M. Mizuno, T. Kawamura, Y. Hista, K. Okuda, Y. Noro, Z. X. X. Zheng, and D. Fang (1988) Cultivation and saponin contents of Guangxi Bupleurum. Jap. J. Pharmacogn. 42: 236-239.
16. Mizukami, H., K. Matsunaga, H. Ohashi, A. Amano, T. Maekawa, and K. Fujimoto (1991) Variation in saikosaponin content of Bupleurum falcatum L. of different geographical origins. Jap. J. Pharmacogn. 45: 342-344.
17. Park, Y. J., J. D. Seong, H. Y. Kim, H. S. Suh, and J. W. Shim (1994) Root yield and saikosaponin content in local strains of Bupleurum falcatum L. Kor. J. Crop Sci. 39: 453-457.
18. Hosoda, K., M. Noguchi, T. Ikenaga, Y. Hisata, and Y. Noro (1995). Studies on the cultivation of Bupleurum falcatum L. (VI). Variation in lignification index of B. falcutum of different geographical origins. Nat. Med. 49: 11-13.
19. Watanabe, T. T., S. Yoshikawa, A. Isoda, H. Takada, A. Ishiguro, H. Namera, K. Kohda, J. Malla, and A. Takano (1998) Studies on the medicinal plant resources of the Himalayas (2). Qualitative and quantitative evaluation of saikosaponins of some Bupleurum roots collected in Nepal. Nat. Med. 52: 421-425.
20. Chang, S. M., B. Y. Park, and J. Choi (1990) Effects of the soil fertility and the inorganic nutrients in the root on the contents of saikosaponin a, c in the root of Bupleurum falcatum L. J. Kor. Soc. Soil Sci. & Fert. 23: 49-52.
21. Minami, M. and M. Sugino (1995) Effects of mineral fertilizers on growth and saikosaponins contents of Bupleurum falcatum L. (I). Effects of different levels of nitrogen, phosphoric acid, and potassium on growth and saikosaponins contents of one-year-old plant. Nat. Med. 49: 230-239.
22. Ahn, J. C., Y. W. Paek, C. K. Sung, G. H. Kang, and B. Hwang (1993) Production of saponin content by hairy root culture of Bupleurum falcatum. 1. Comparison of saponin content and pattern in callus, adventitious root, hairy root, and cultivated root. Kor. J. Botany 36: 43-49.
23. Aoyagi, H., Y. Kobayashi, K. Yamada, M. Yokoyama, K. Kusakari, and H. Tanaka (2001) Efficient production of saikosaponins in Bupleurum falcatum root fragments combined with signal transducers. Appl. Microbiol. Biotechnol. 57: 482-488.
24. Ahn, J. C., E. S. Kim, H. J. Lee, and B. Hwang (1999) Effects of media and LAA and IBA on growth and saikosaponin production with Bupleurum falcatum hairy root culture. Kor. J. of Plant Tissue Cult. 26: 171-175.
25. Ahn, J. C, Y. J. Jeong, K. B. Lee, O. T. Kim, and B. Hwang. (1999b) The effects of variations culture media on histological anatomy and saikosaponin content in hairy root culture of Bupleurum falcatum. Kor. J. Medicinal Crop. 7: 251-256.
26. Kusakari, K., M. Yokoyama, and S. Inomata (2000) Enhanced production of saikosaponin by root culture of Bupleurum falcatum L. using two-step control of sugar concentration. Plant Cell Rep. 19: 1115-1120.
27. Hirasuna, T. J., L. J. Pestchanker, V. Srinivasan, and M. L. Shuler (1996) Taxol production in suspension cultures of Taxus baccata. Plant Cell Tissue Organ Cult. 44: 95-102.
28. Yamada, J., K. Hujita, and K. Sakai (2003) Effect of major inorganic nutrients on β-thujaplicin production in a suspension culture of Cupressus lusitanica cells. J. Wood Sci. 49: 172-175.
29. Park, Y. G., S. J. Km, Y. M. Kang, H. Y. Jung, D. T. Prasad, S. W. Kim, Y. G. Chung, and M. S. Choi (2004) Production of ginkgolides and bilobalide from optimized the Ginkgo biloba cell culture. Biotechnol. Bioprocess Eng. 9: 41-46.
30. Jeong, G. T. and D. H. Park (2005) Enhancement of growth and secondary metabolite biosynthesis: Effect of elicitors derived from plants and insects. Biotechnol. Bioprocess Eng. 10: 73-77.
31. Jeong, G. T. and D. H. Park (2006) Characteristics of transformed Panax ginseng C.A. Meyer hairy roots: Growth and nutrient profile. Biotechnol. Bioprocess Eng. 11: 43-47.
32. Murashige, T. and F. Skoog (1962) A revised media for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant 15: 473-497.
33. Wifte, F. F. and E. W. Nester (1980) Relationship of plasmids responsible for hairy root and crown gall tumorigenicity. J. Bacteriol. 144: 710-720.
34. Srinivasan, V. and D. D. Y. Ryu (1993) Improvement of shikonin productivity in Lithospermum erythrorhizon cell culture by alternating carbon and nitrogen feeding strategy. Biotechnol. Bioeng. 42: 793-799.
35. Touria, E. J. and C. Douglas (1998) Effect of plant age on nitrogen uptake and distribution by greenhouse plants. J. Plant Nutr. 21: 1055-1066.
36. Paek, Y. W., J. C. Ahn, B. G. Jung, S. U. Kim, and B. Hwang (1993) Betaline production by hairy root cultures of red beet (Beta vulgaris L.). Kor. J. Plant Tissue Cult. 20: 159-165.
37. Zhong, J. J. and Q. X. Zhu (1995) Effect of initial phosphate concentration on cell growth and ginsenoside saponin production by suspended cultures of Panax notoginseng. Appl. Biochem. Biotechnol. 55: 241-247.
38. Fulcheri, C., P. Morard, and M. Henry (1998) Stimulation of the growth and the triterpenoid saponin accumulation of Saponaria officinalis cell and Gypsophila paniculata root suspension cultures by improvement of the mineral composition of the media. J. Agric. Food Chem. 46: 2055-2061.
39. El Badaoui, H., P. Morard, and M. Henry (1996) Stimulation of the growth and solamargine production by Solanum paludosum multiple shoot cultures using a new culture media. Plant Cell Tissue Organ Cult. 45: 153-158.
40. Satake, M. (1991) Production and resources of Bupleurum root (root of sickle hare's ear). Gendai Toyo Igaku 12: 71-78.
41. Uomori, A., S. Seo, and Y. Tomita (1974) Studies on the constituents in tissue cultures of Bupleurum falcatum L. Shoyakugaku Zasshi 28: 152-160.