Inhaled nitric oxide does not reduce systemic vascular resistance in mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 290, Issue 5, 2006, Pages

  Hataishi, Ryuji ^a   Zapol, Warren M ^a   Bloch, Kenneth D ^a   Ichinose, Fumito ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Endothelial nitric oxide synthase; Peripheral vasodilation; Tail cuff; Telemetry

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DRUG MECHANISM; GENERAL ANESTHESIA; GENOTYPE; HEART LEFT VENTRICLE FUNCTION; HEART OUTPUT; IN VIVO STUDY; LUNG HEMODYNAMICS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC VASCULAR RESISTANCE; TELEMETRY; VASODILATATION; WILD TYPE;

ADMINISTRATION, INHALATION; ANIMALS; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; VASCULAR RESISTANCE; VASODILATION;

EID: 33646416176     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00938.2005     Document Type: Article

References (14)

1. Adrie C, Bloch KD, Moreno PR, Hurford WE, Guerrero JL, Holt R, Zapol WM, Gold HK, and Semigran MJ. Inhaled nitric oxide increases coronary artery patency after thrombolysis. Circulation 94: 1919-1926, 1996.
2. G-monomethyl-L-arginine causes nitric oxide synthesis in isolated arterial rings: trouble in paradise. Biochem Biophys Res Commun 188: 590-596, 1992.
3. G-nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ Res 72: 387-395, 1993.
4. Cannon RO III, Schechter AN, Panza JA, Ognibene FP, Pease-Fye ME, Waclawiw MA, Shelhamer JH, and Gladwin MT. Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. J Clin Invest 108: 279-287, 2001.
5. Fox-Robichaud A, Payne D, Hasan SU, Ostrovsky L, Fairhead T, Reinhardt P, and Kubes P. Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds. J Clin Invest 101: 2497-2505, 1998.
6. Hataishi R, Morgan JG, Rodorigues ACT, Ichinose F, Zapol WM, Picard MH, Bloch KD, and Scherrer-Crosbie M. Inhaled nitric oxide limits murine ischemia-reperfusion injury (Abstract). Circulation 234: 2004.
7. Hogman M, Frostell C, Arnberg H, Sandhagen B, and Hedenstierna G. Prolonged bleeding time during nitric oxide inhalation in the rabbit. Acta Physiol Scand 151: 125-129, 1994.
8. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, and Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 377: 239-242, 1995.
9. Ichinose F, Roberts JD Jr, and Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation 109: 3106-3111, 2004.
10. Lee JS, Adrie C, Jacob HJ, Roberts JD Jr, Zapol WM, and Bloch KD. Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res 78: 337-342, 1996.
11. Ng ES, Jourd'heuil D, McCord JM, Hernandez D, Yasui M, Knight D, and Kubes P. Enhanced S-nitroso-albumin formation from inhaled NO during ischemia/reperfusion. Circ Res 94: 559-565, 2004.
12. Obst M, Gross V, and Luft FC. Systemic hemodynamics in nonanesthetized L-NAME- and DOCA-salt-treated mice. J Hypertens 22: 1889-1894, 2004.
13. Stamler JS, Singel DJ, and Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science 258: 1898-1902, 1992.
14. Steudel W, Ichinose F, Huang PL, Hurford WE, Jones RC, Bevan JA, Fishman MC, and Zapol WM. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ Res 81: 34-41, 1997.