Arsenic trioxide reduces the invasive and metastatic properties of nasopharyngeal carcinoma cells in vitro

Brazilian Journal of Medical and Biological Research

Volumn 39, Issue 5, 2006, Pages 677-685

  Du, C W ^a   Wen, B G ^a   Li, De Rui ^a   Peng, X ^a   Hong, C Q ^a   Chen, J Y ^a   Lin, Z Z ^a   Hong, X ^a   Lin, Y C ^a   Xie, L X ^a   Wu, M Y ^a   Zhang, H ^b  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Latent membrane protein 1; Metalloproteinase 9; Metastases; Nasopharyngeal carcinoma

Indexed keywords

ANTIMETASTATIC AGENT; ARSENIC TRIOXIDE; GELATINASE B; LATENT MEMBRANE PROTEIN 1;

ANALYSIS OF VARIANCE; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; METASTASIS; METASTASIS INHIBITION; METASTASIS POTENTIAL; MIGRATION INHIBITION; NASOPHARYNX CARCINOMA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

HUMAN HERPESVIRUS 4;

EID: 33646387712     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2006000500015     Document Type: Article

References (16)

1. Li DR, Du CW, Lin YC et al. (2002). Inhibition of growth of human nasopharyngeal cancer xenografts in SCID mice by arsenic trioxide. Tumori, 88: 522-526.
2. 3. National Medical Journal of India, 17: 67-70.
3. Li DR, Lin YC, Xie LX et al. (2003). Arsenic trioxide enhances radiosensitivity in vitro of nasopharyngeal carcinoma. Experimental Oncology, 25: 248-251.
4. Zhu HC, Yao KT, Li GY et al. (1992). Establishment and characteristic analysis of four epithelial tumor cell lines derived from NPC. Journal of Human Medical University (in Chinese), 17: 103-107.
5. Jiang Y, Xu W, Lu J et al. (2001). Invasiveness of hepatocellular carcinoma cell lines: contribution of hepatocyte growth factor, c-met, and transcription factor Ets-1. Biochemical and Biophysical Research Communications, 286: 1123-1130.
6. Kam MK, Teo PM, Chau RM et al. (2004). Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the Hong Kong experience. International Journal of Radiation Oncology, Biology, Physics, 60: 1440-1450.
7. Lee N, Xia P, Quivey JM et al. (2002). Intensity-modulated radio-therapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience. International Journal of Radiation Oncology, Biology, Physics, 53: 12-22.
8. Vuky J, Yu R, Schwartz L et al. (2002). Phase II trial of arsenic trioxide in patients with metastatic renal cell carcinoma. Investigational New Drugs, 20: 327-330.
9. Antman KH (2001). Introduction: The history of arsenic trioxide in cancer therapy. Oncologist, 6 (Suppl 2): 1-2.
10. Shen ZY, Shen J, Chen JY et al. (2003). The inhibition of growth and angiogenesis in heterotransplanted esophageal carcinoma via intratumoral injection of arsenic trioxide. Oncology Reports, 10: 1869-1874.
11. Wei LH, Lai KP, Chen CA et al. (2005). Arsenic trioxide prevents radiation-enhanced tumor invasiveness and inhibits matrix metallo-proteinase-9 through downregulation of nuclear factor kappa B. Oncogene, 24: 390-398.
12. Li HP & Chang YS (2003). Epstein-Barr virus latent membrane protein 1: structure and functions. Journal of Biomedical Science, 10: 490-504.
13. Lo AK, Huang DP, Lo KW et al. (2004). Phenotypic alterations induced by the Hong Kong-prevalent Epstein-Barr virus-encoded LMP1 variant (2117-LMP1) in nasopharyngeal epithelial cells. International Journal of Cancer, 109: 919-925.
14. Murono S, Inoue H, Tanabe T et al. (2001). Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells. Proceedings of the National Academy of Sciences, USA, 98: 6905-6910.
15. Ren Q, Sato H, Murono S et al. (2004). Epstein-Barr virus (EBV) latent membrane protein 1 induces interleukin-8 through the nuclear factor-kappa B signaling pathway in EBV-infected nasopharyngeal carcinoma cell line. Laryngoscope, 114: 855-859.
16. Horikawa T, Yoshizaki T, Sheen TS et al. (2000). Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma. Cancer, 89: 715-723.