Genotoxical, teratological and biochemical effects of anthelmintic drug oxfendazole Maximum Residue Limit (MRL) in male and female mice

Reproduction Nutrition Development

Volumn 46, Issue 2, 2006, Pages 139-156

  El Makawy, Aida ^a   Radwan, Hasnaa A ^a   Ghaly, Inas S ^a   El Raouf, A Abd ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Anthelmintic; Biochemical changes; Embryotoxicity; Genotoxicity; Maximum residue limit; Oxfendazole; Teratogenicity

Indexed keywords

ANTHELMINTIC AGENT; OXFENDAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DISEASE; CHEMICAL ANALYSIS; CHROMOSOME ABERRATION; CONTROLLED STUDY; EMBRYO; FEMALE; FETUS CELL; GENOTOXICITY; MALE; MOUSE; MUTAGENESIS; NONHUMAN; OSSIFICATION; SEX DIFFERENCE; TERATOGENESIS;

ANIMALS; ANTHELMINTICS; BENZIMIDAZOLES; CONSUMER PRODUCT SAFETY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESIDUES; FEMALE; FOOD CONTAMINATION; HUMANS; MALE; MAXIMUM TOLERATED DOSE; MEAT; MICE; MUTAGENICITY TESTS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; TERATOGENS; TOXICITY TESTS;

ANIMALIA; BOS TAURUS; OVIS ARIES;

EID: 33646381886     PISSN: 09265287     EISSN: 12979708     Source Type: Journal    
DOI: 10.1051/rnd:2006007     Document Type: Article

References (47)

1. Delatour P, Parish R. Drug residues in animals. Ed Rico AG, Academic Press, New York, USA 1986.
2. Klee S, Baumung I, Kluge K, Ungemach FR, Horne E, O Keeffe M, De Angelis I, Vignoli AL, Zucco F, Stammati A. A contribution to safety assessment of veterinary drug residues: in vitro/ex vivo studies on the intestinal toxicity and transport of covalently bound residues. Xenobiotica 1999, 29: 641-654.
3. FAO/WHO Expert Committee on Food Additives, Evaluation of certain veterinary drug residues in food, Fiftieth report of the joint World Health Organ Tech Rep Ser 1999, 888: 1-95.
4. Prichard RK, Ranjan S. Anthelmintics. Vet Parasitol 1993, 46: 113.
5. Rose MD, Bygrave J, Farrington WH, Shearer G. The effect of cooking on veterinary drug residues in food, Part 8. Benzylpenicillin. Analyst 1997, 122: 1095-1099.
6. McGrane M, Okeeffe M, Smyth MR. Multi-residue analysis of penicillin residues in porcine tissue using matrix solid phase dispersion. Analyst 1998, 123: 2779-2783.
7. Galer DM, Monro AM. Veterinary drugs no longer need testing for carcinogenicity in rodent bioassays. Regulatory Toxicology and Pharmacology 1998, 28: 115-123.
8. Nagalakshmi K, Tong-man O. Occupational exposure to genotoxic agents. Mut Res 1999, 437: 175-194.
9. Yosida TH, Amano K. Autosomal polymorphic in laboratory bred and Wild Norway rats Rattus norvegicus, found in Misima. Chromosoma 1965, 16: 658-666.
10. Brewen GJ, Preston JR. Analysis of chromosome aberrations in mammalian germ cells. Chemical Mutagenesis 1978, 5: 127-150.
11. Gleich J, Frohberg H. General teratological technique. In: Methods in prenatal toxicology, George Thieme Publishers, Stuttgart, 1977.
12. Weesner FM. General zoological microtechniques. Scientific Book Indian Ed, Agency Calcutta, 1968, p 100-101.
13. Romagnano A, King AW, Richer CL, Perrone MA. A direct technique for the preparation of chromosomes from early equine embryos. J Gent Cytol 1985, 27: 365-369.
14. Dische Z. Color reaction of nucleic acid components. In: Chargaff E, Davidson JM (Eds), The nucleic acids, vol 1, Academic press, New York, 1955, 270-284.
15. Schneider WC. Determination of acid in tissues by pentose analysis. In: Colowick SP, Kaplan NO (Eds), Method enzymology, Academic press, New York, 1957, p 680-684.
16. Gomall AC, Bardaawill CJ, David MM. Protein clometric method. J Biol Chem 1949, 177: 751-760.
17. Reitman S, Frankel S. Got and Gpt colometric method. Am J Clin Path 1957, 28: 26-30.
18. Kirkpatrick D. The veterinary drugs directorate to discuss EXTRA-LABEL drug use in Halifax. Can Vet J 2002, 43: 425-426.
19. Crebelli R, Thershold-mediated mechanisms in mutagenesis: implications in the classification and regulation of chemical mutagens. Mut Res 2000, 464: 129-135.
20. Ardito G, Bramanti B, Bigatti P, Lamberti L, Dolara P. Cytogenetic effect of thiabendazole and diphenylammine on cultured human lymphocytes; sister chromatid exchanges and cell cycle delay. Boll Soc Ital Biol Sper 1996, 72: 171-178.
21. Crebelli R, Conti G, Conti L, Carere A. In vitro studies with nine known or suspected spindle poisons: results in tests for chromosome malsegregation in Aspergillus nidulans. Mutagenesis 1991, 6: 131-136.
22. Leopardi P, Zijno A, Bassani B, Pacchierotti F. In vivo studies on chemically induced aneuploidy in mouse somatic and germinal cells. Mut Res 1993, 287: 119-130.
23. Natarajan AT, Duivenvoorden WC, Meijers M, Zwanenburg TS. Induction of mitotic aneuploidy using chinese hamster primary embryonic cells. Test results of 10 chemicals. Mut Res 1993, 287: 47-56.
24. Parry J.M, Sors A. The detection and assessment of the aneugenic potentials of environmental chemicals. The European Community Aneuploidy project. Mut Res 1993, 287: 3-15.
25. Mailhes JB, Young D, Aardema MJ, London SN. Thiabendazole-induced cytogenetic abnormalities in mouse oocytes. Environ Mol Mutagen 1997, 29: 367-371.
26. Adler ID, Schmid TE, Baumgartner A. Induction of aneuploidy in male mouse germ cells detected by the sperm-FISH assay: a review of the present data base. Mutat Res 2002, 504: 173-182.
27. Schmid TE, Xu W, Adler ID. Detection of aneuploidy by multicolor FISH in mouse sperm after in vivo treatment with acrylamide, colchicine, diazepam or thiabendazole. Mutagenesis 1999, 14: 173-179.
28. Barale R, Scapoli C, Meli C, Casini D, Minunni M, Marrazzini A, Loprieno N, Barrai I. Cytogenetic effects of benzimidazoles in mouse bone marrow. Mut Res 1993, 300: 15-28.
29. De la Torre RA, Espinosa-Aguirre JJ, Cortinas de Nava C, Izquierdo T, Moron F. Genotoxic activity of menbendazole in Aspergillus nidulans. Mut Res 1994, 305: 139-144.
30. Okamura M, Watanabe T, Kashida Y, Machida N, Mitsumori K. Possible mechanisms underlying the testicular toxicity of oxfendazole in rats. Toxicol Pathol 2004, 32: 1-8.
31. Uppala PT, Roy SK, Tousson A, Barnes S, Uppala GR, Eastmond DA. Induction of cell proliferation, micronuclei and hyperdiploidy/polyploidy in the mammary cells of DDT- and DMBA-treated pubertal rats. Environ Mol Mutagen 2005, 46: 43-52.
32. Delatour P, Parish RC, Gyurik RJ. Albendazole: a comparison of relay embryotoxicity with embryotoxicity of individual metabolites. Ann Rech Vet 1981, 12: 159-167.
33. Delatour P. Some aspects of the teratogenicity of veterinary drugs. Vet Res Commun 1983, 7: 125-131.
34. Scholz D, Baeder O. A teratogenicity test of HOE 881 with oral administration in yellow-silver rabbits. Hoechst-Roussel unpublished report, submitted to WHO by Hoechst AG, Frankfurt am Main, Germany, 1973.
35. Lankas GR, Nakatsuka T, Komatsu T, Matsumoto H. Developmental toxicity of orally administered thiabendazole in ICR mice. Food Chem Toxicol 2001, 39: 367-374.
36. Delatour P, Gamier F, Benoit E, Longin C. A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues. J Vet Pharmacol Ther 1984, 7: 139-145.
37. Whittaker SG, Faustman EM. Effects of albendazole and albendazole sulfoxide on cultures of differentiating rodent embryonic cells. Toxicol Appl Pharmacol 1991, 109: 73-84.
38. Whittaker SG, Faustman EM. Effects of benzimidazole analogs on cultures of differentiating rodent embryonic cells. Toxicol Appl Pharmacol 1992, 113: 144-151.
39. Capece BP, Navarro M, Arcalis T, Castells G, Toribio L, Perez F, Carretero A, Ruberte J, Arboix M, Cristofol C. Albendazole sulphoxide enantiomers in pregnant rats embryo concentrations and developmental toxicity. Vet J 2003, 165: 266-275.
40. Navarro M, Canut L, Carretero A, Cristofol C, Perez-Aparicio FJ, Arboix M, Ruberte J. Developmental toxicity in rat fetuses exposed to the benzimidazole netobimin. Reprod Toxicol 1999, 13: 295-302.
41. Mantovani A. The role of multigeneration studies in safety assessment of residues of veterinary drugs and additives. Ann Ist Super Sanita 1992, 28: 429-435.
42. Teruel MT, Felipe AE, Solana HD, Sallovitz JM, Lanusse CE. Placental and fetal toxicity of albendazole sulphoxide in Wistar rats. Vet Hum Toxicol 2003, 45: 131-136.
43. Cristofol C, Navarro M, Franquelo C, Valladares JE, Carretero A, Ruberte J, Arboix M. Disposition of netobimin, albendazole and its metabolites in the pregnant rats developmental toxicity. Toxicol Appl Pharmacol 1997, 144: 56-61.
44. El-Makawy A. Mutagenic and teratogenic studies induced by anticancer (cisplatinum) in rat embryos. A Thesis submitted for the fulfillment of PhD degree in science, 1998.
45. Baliharova V, Velik J, Lamka J, Balarinova R, Skalova L. The effects of albendazole and its metabolites on hepatic cytochromes P450 activities in mouflon and rat. Res Vet Sci 2003, 75: 231-239.
46. Tada Y, Fujitani T, Yoneyama M. Subchronic toxicity of thiabendazole (TBZ) in ICR mice. Food Chem Toxicol 1996, 34: 709-716.
47. Karmakar R, Banerjee A, Datta S, Chatterjee M. Influence of cadmium intoxication on hepatic lipid peroxidation, glutathione level, and glutathione S-transferase and gamma-glutamyl transpeptidase activities: correlation with chromosome aberrations in bone marrow cells. J Environ Pathol Toxicol Oncol 1999, 18: 277-287.