Nitric oxide regulation of microvascular oxygen exchange during hypoxia and hyperoxia

Journal of Applied Physiology

Volumn 100, Issue 4, 2006, Pages 1181-1187

  Cabrales, Pedro ^a   Tsai, Amy G ^a,b   Intaglietta, Marcos ^a,b  

^a LA JOLLA BIOENGINEERING INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Microcirculation; Vascular regulation; Vessel wall oxygen consumption

Indexed keywords

NITRIC OXIDE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; ENERGY EXPENDITURE; HAMSTER; HYPEROXIA; HYPOXIA; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN SUPPLY; OXYGEN TENSION; OXYGEN TRANSPORT; PRIORITY JOURNAL; REGULATORY MECHANISM; VASOCONSTRICTION;

ANIMALS; ANOXIA; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CRICETINAE; CYCLIC N-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; HYPEROXIA; IMIDAZOLES; MICROCIRCULATION; NITRIC OXIDE; OXYGEN; SKIN; VASOCONSTRICTION;

EID: 33646376664     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01105.2005     Document Type: Article

References (34)

1. Akaike T, Yoshida M, and Miyamoto Y. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32: 827-832, 1993.
2. Busse R, Forstermann U, Masuda H, and Pohl U. The role of prostaglandins in endothelium-mediated vasodilatory response to hypoxia. Pflügers Arch 401: 77-83, 1984.
3. Cabrales P, Tsai AG, Frangos JA, and Intaglietta M. Role of endothelial nitric oxide in microvascular oxygen delivery and consumption. Free Radic Biol Med 39: 1229-1237, 2005.
4. 2 delivery and consumption after 80% exchange transfusion with polymerized hemoglobin. Am J Physiol Heart Circ Physiol 287: H2825-H2833, 2004.
5. Cabrales P, Tsai AG, and Intaglietta M. Microvascular pressure and functional capillary density in extreme hemodilution with low and high plasma viscosity expanders. Am J Physiol Heart Circ Physiol 287: H363-H373, 2004.
6. Clementi E, Brown GC, Foxwell N, and Moncada S. On the mechanism by which vascular endothelial cells regulate their oxygen consumption. Proc Natl Acad Sci USA 96: 1559-1562, 1999.
7. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO III, and Gladwin MT. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 9: 1498-1505, 2003.
8. D'Orio V, Wahlen C, and Rodriguez L. A comparison of Escherichia coli endotoxin single bolus injection with low-dose endotoxin infusion on pulmonary and systemic vascular changes. Circ Shock 21: 207-216, 1987.
9. Dweik R, Laskowski D, Abu-Soud H, Kaneko F, Hutte R, Stuehr D, and Erzurum S. Nitric oxide synthesis in the lung. J Clin Invest 101: 660-666, 1998.
10. Edmunds NJ and Marshall JM. Oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: role of adenosine. J Physiol 536: 927-935, 2001.
11. Edmunds NJ and Marshall JM. The roles of nitric oxide in dilating proximal and terminal arterioles of skeletal muscle during systemic hypoxia. J Vasc Res 40: 68-76, 2003.
12. Edmunds NJ, Moncada S, and Marshall JM. Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies. J Physiol 546: 521-527, 2003.
13. Endrich B, Asaishi K, Götz A, and Messmer K. Technical report: a new chamber technique for microvascular studies in unanaesthetized hamsters. Res Exp Med (Berl) 177: 125-134, 1980.
14. Friesenecker B, Tsai AG, Dunser MW, Mayr AJ, Martini J, Knotzer H, Hasibeder W, and Intaglietta M. Oxygen distribution in the microcirculation following arginine vasopressin-induced arteriolar vasoconstriction. Am J Physiol Heart Circ Physiol 287: H1792-H1800, 2004.
15. Hangai-Hoger N, Tsai AG, Friesenecker B, Cabrales P, and Intaglietta M. Microvascular oxygen delivery and consumption following treatment with verapamil. Am J Physiol Heart Circ Physiol 288: H1515-H1520, 2005.
16. Intaglietta M, Silverman NR, and Tompkins WR. Capillary flow velocity measurements in vivo and in situ by television methods. Microvasc Res 10: 165-179, 1975.
17. Intaglietta M and Tompkins WR. Microvascular measurements by video image shearing and splitting. Microvasc Res 5: 309-312, 1973.
18. 2 measurements by phosphorescence quenching: characteristics and applications of an automated system. Microvasc Res 65: 32-38, 2003.
19. King CE, Melinyshyin MJ, Mewburn JD, Curtis SE, Winn MJ, Cain SM, and Chapler CK. Canine hindlimb flow and O2 uptake after inhibition of EDRF/NO synthesis. J Appl Physiol 76: 1166-1171, 1994.
20. Lipowsky HH and Zweifach BW. Application of the "two-slit" photometric technique to the measurement of microvascular volumetric flow rates. Microvasc Res 15: 93-101, 1978.
21. Marshall JM. Adenosine and muscle vasodilatation in acute systemic hypoxia. Acta Physiol Scand 168: 561-573, 2000.
22. Messina EJ, Sun D, Koller A, Wolin MS, and Kaley G. Increases in oxygen tension evoke arteriolar constriction by inhibiting endothelial prostaglandin synthesis. Microvasc Res 48: 151-160, 1994.
23. Moncada S, Palmer MJ, and Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-134, 1991.
24. Nagababu E, Ramasamy S, Abernethy DR, and Rifkind JM. Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction. J Biol Chem 278: 46349-46356, 2003.
25. Prewitt RL and Johnson PC. The effect of oxygen on arteriolar red cell velocity and capillary density in the rat cremaster muscle. Microvasc Res 12: 59-70, 1976.
26. Shaul P, Smart WEJ, Robinson LJ, German Z, Yuhanna IS, Ying Y, Anderson RG, and Michel T. Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem 271: 6518-6522, 1996.
27. Shen W, Xu X, Ochoa M, Zhao G, Wolin MS, and Hintze TH. Role of nitric oxide in the regulation of oxygen consumption in conscious dogs. Circ Res 75: 1086-1095, 1994.
28. Shibata M, Ichioka S, and Kamiya A. Estimating oxygen consumption rates of arteriolar walls under physiological conditions in rat skeletal muscle. Am J Physiol Heart Circ Physiol 289: H295-H300, 2005.
29. Shibata M, Ichioka S, and Kamiya A. Nitric oxide modulates oxygen consumption by arteriolar walls in rat skeletal muscle. Am J Physiol Heart Circ Physiol 289: H2673-H2679, 2005.
30. Skinner MR and Marshall JM. Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. J Physiol 495: 553-560, 1996.
31. 2 measurements by phosphorescence decay method. Am J Physiol Heart Circ Physiol 265: H1434-H1438, 1993.
32. Tsai AG, Cabrales P, Winslow RM, and Intaglietta M. Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia. Am J Physiol Heart Circ Physiol 285: H1537-H1545, 2003.
33. Tsai AG, Friesenecker B, Mazzoni MC, Kerger H, Buerk DG, Johnson PC, and Intaglietta M. Microvascular and tissue oxygen gradients in the rat mesentery. Proc Natl Acad Sci USA 95: 6590-6595, 1998.
34. Tsai AG, Johnson PC, and Intaglietta M. Oxygen gradients in the microcirculation. Physiol Rev 83: 933-963, 2003.