Type 5 Phosphodiesterase Inhibitors: Curing Erectile Dysfunction

European Urology

Volumn 49, Issue 6, 2006, Pages 942-945

  Hellstrom, Wayne J G ^a   Kendirci, Muammer ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; PHOSPHODIESTERASE V INHIBITOR; PROSTAGLANDIN E1; SILDENAFIL; TADALAFIL; VARDENAFIL; VASOACTIVE AGENT;

AGING; ANGIOGENESIS; CARDIOVASCULAR RISK; CHRONIC DRUG ADMINISTRATION; CHRONOTHERAPY; CLINICAL TRIAL; DISEASE ASSOCIATION; EDITORIAL; ENDOTHELIAL DYSFUNCTION; ERECTILE DYSFUNCTION; EVIDENCE BASED MEDICINE; FUNCTIONAL ASSESSMENT; HUMAN; LONG TERM CARE; LOW DRUG DOSE; NERVOUS SYSTEM DEVELOPMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; PENIS ERECTION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROPHYLAXIS; PROSTATECTOMY; RISK FACTOR; SEXUAL FUNCTION; TREATMENT DURATION; TREATMENT OUTCOME; VASCULAR DISEASE;

ANIMALS; ERECTILE DYSFUNCTION; HUMANS; IMPOTENCE; MALE; PHOSPHODIESTERASE INHIBITORS;

EID: 33646374167     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2006.02.063     Document Type: Editorial

References (20)

1. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 270 (1993) 83-90
2. Feldman H.A., Goldstein I., Hatzichristou D.G., Krane R.J., and McKinlay J.B. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 151 (1994) 54-61
3. Bivalacqua T.J., Usta M.F., Champion H.C., Kadowitz P.J., and Hellstrom W.J. Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease. J Androl 24 (2003) S17-S37
4. Moreland R.B. Pathophysiology of erectile dysfunction: the contributions of trabecular structure to function and the role of functional antagonism. Int J Impot Res 12 (2000) S39-S46
5. Montorsi F., Briganti A., Salonia A., Rigatti P., and Burnett A.L. Can phosphodiesterase type 5 inhibitors cure erectile dysfunction?. Eur Urol 49 (2006) 979-986
6. Rosano G.M., Aversa A., Vitale C., Fabbri A., Fini M., and Spera G. Chronic treatment with tadalafil improves endothelial function in men with increased cardiovascular risk. Eur Urol 47 (2005) 214-220 discussion p. 220-2
7. Desouza C., Parulkar A., Lumpkin D., Akers D., and Fonseca V.A. Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes. Diabetes Care 25 (2002) 1336-1339
8. Caretta N., Palego P., Ferlin A., et al. Resumption of spontaneous erections in selected patients affected by erectile dysfunction and various degrees of carotid wall alteration: role of tadalafil. Eur Urol 48 (2005) 326-331 discussion p. 331-2
9. Sommer F., and Schulze W. Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors. World J Urol 23 (2005) 385-392
10. Montorsi F., Guazzoni G., Strambi L.F., et al. Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial. J Urol 158 (1997) 1408-1410
11. Montorsi F., Maga T., Strambi L.F., et al. Sildenafil taken at bedtime significantly increases nocturnal erections: results of a placebo-controlled study. Urology 56 (2000) 906-911
12. Padma-Nathan H., McCullough A., Giuliano F., Toler S.M., Wohlhuter C., and Shpilsky A.B. Postoperative nightly administration of sildenafil citrate significantly improved the return of normal spontaneous erectile function after bilateral nerve-sparing radical prostatectomy. J Urol 4 (2003) 375
13. Mulhall J., Land S., Parker M., Waters W.B., and Flanigan R.C. The use of an erectogenic pharmacotherapy regimen following radical prostatectomy improves recovery of spontaneous erectile function. J Sex Med 2 (2005) 532-542
14. Behr-Roussel D., Gorny D., Mevel K., et al. Chronic sildenafil improves erectile function and endothelium-dependent cavernosal relaxations in rats: lack of tachyphylaxis. Eur Urol 47 (2005) 87-91
15. 2-dependent prostanoid synthesis activates functional PGE receptors on corpus cavernosum smooth muscle. Am J Physiol Heart Circ Physiol 281 (2001) H552-H558
16. Schwartz E.J., Wong P., and Graydon R.J. Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy. J Urol 171 (2004) 771-774
17. Foresta C., Lana A., Cabrelle A., et al. PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans. Int J Impot Res 17 (2005) 377-380
18. Garmy-Susini B., and Varner J.A. Circulating endothelial progenitor cells. Br J Cancer 93 (2005) 855-858
19. Foresta C., Caretta N., Lana A., Cabrelle A., Palu G., and Ferlin A. Circulating endothelial progenitor cells in subjects with erectile dysfunction. Int J Impot Res 17 (2005) 288-290
20. Burnett A.L. Vasoactive pharmacotherapy to cure erectile dysfunction: fact or fiction?. Urology 65 (2005) 224-230